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Biomedical subjects

J Binder

Publications and source records attributed to J Binder.

18 recordsLinked to original sources
PubMed1992

Distinct syndromes of hemineglect.

Hemineglect was assessed in 34 patients with right-hemisphere stroke using a letter-cancellation task and a line bisection task. No significant correlation (r = .39) was found between scores on the two tests. Ten patients who showed neglect on the cancellation task but performed normally on line bisection had frontal or deep lesions. Eleven patients with posterior lesions deviated rightward on line bisection; several of these had minimal or no cancellation deficit. A nonmotor task involving judgment of a bisected line was also performed abnormally by six patients with line bisection shift, suggesting that such shift does not result from a motor response asymmetry. We propose that separable components of the neglect syndrome may be associated with damage to discrete areas of the nondominant hemisphere.

Adult↗
PubMed1990

[Quality assurance in clinical studies: a necessity].

Good Laboratory Practice (GLP), Good Manufacturing Practice (GMP), and Good Clinical Practice (GCP) are the constituents of a new concept for quality assurance in pharmaceutical research. They are to establish standards for preclinical and experimental research in animals (GLP), for the manufacturing of drugs (GMP), and for trials on medical products in human beings (GCP), respectively. Each of the 3 entities is characterized by the same principles of control; these involve written instruction describing the general operations to be performed, the so called Standard Operating Procedures (SOP), and Quality Assurance Units being responsible for surveying the operations in accordance with the SOP, and ensuring that the generated data will satisfy the requirements for quality. As far as clinical trials are concerned, the SOP is represented by the study protocol and a Monitor provides for the surveying of the trial. GCP is further characterized by ethical principles, which aim primarily at protecting personal integrity and welfare of the trial subjects. The Declaration of Helsinki is the accepted basis for clinical trial ethics. Following the Declaration of Helsinki during the planning, conducting, surveying and evaluating of clinical trials provides for a degree of seriousness being the real hallmark of Good Clinical Practice.

Animals↗
PubMed1986

[Vipoma. 9-year observations using currently available therapy methods].

A now 61-year old man with hypersecretion of vasoactive intestinal polypeptide (VIP) due to carcinoma of the tail of the pancreas was treated and followed for nine years. Combined administration of lomustin (2.5 mg/kg on day 1) and 5-fluorouracil (30 mg/kg on days 2-6) over eight courses at six-week intervals achieved clinical remission for 13 months. No clinical improvement was observed with streptozocin (500 mg/m2 on days 1-5) for two courses four weeks apart. Treatment had to be discontinued after the second course because of the onset of (rarely observed) neurotoxic side-effect of bilateral peroneal paresis. High doses of somatostatin (6.9 micrograms/kg hourly intravenously) immediately and markedly reduced stool quantity. But at a lower dose (3.4 micrograms/kg hourly i.v.) there was no noticeable effect. In the further course of the disease, massive attacks of diarrhoea at varying intervals were best controlled in intensity and duration by prednisolone (50-60 mg daily). Other drugs which have been recommended for such cases (indometacin, lithium, trifluoperazine, nicotinic acid and clonidine) had no worth-while effect. In future long-acting somatostatin analogues may provide better prospects for long-term treatment.

Adenoma, Islet Cell↗
PubMed1985

Myotonic dystrophy: obstetric and neonatal complications.

Myotonic dystrophy is a relatively common disorder. Since the clinical expression is highly variable, diagnosis is often made only after the birth of an infant with severe congenital myotonic dystrophy. Seven such cases are described. A history of obstetric complications was present in the six multiparous mothers. Neither the neonatal features nor the pregnancy complications are specific, but their combinations should suggest the diagnosis, which can be confirmed by neurologic evaluation of the infant's mother.

Adult↗
PubMed1979

[Development of narcotics consumption in adolescents 19 and 20 years old. A comparison in the canton of Zurich 1971, 1974 and 1978].

In 1971, 1974 and 1978 representative samples of 19/20-year-old males and females in the Canton of Zurich (Switzerland) answered identical questionnaires on consumption of alcohol, tobacco and drugs. It was thus possible to analyze changes in consumption habits for alcohol, tobacco and drugs by young adults. Consumption patterns changed differently for males and females, with a tendency for females to approach the same levels as males. The number of persons who had been drunk at least once nearly doubled; among men to 68% (as compared to 41% in 1971) and among females to 44% (21%). However, the number of heavy alcohol consumers did not change greatly. The number of cigarette smoking males decreased markedly to 42% (compared to 55%) and is now similar to that of females (43%/41%). The consumption of drugs did not change strikingly. The number of females consuming marijuana increased slightly from 13% to 17%, whereas that of males decreased slightly to 20% (23%). This can be explained by the lower proportion of males with only 1--10 marijuana experiences. The social context of drug consumption shows greater changes than the mere number of consumers: the age of the first drug experience is now considerably lower while differences in drug contact by region or by social strata show a tendency to disappear, with the sole exception of persons without occupational training who now show extremely high drug experiences. It is therefore assumed that drug consumption is no longer a means of self-experience but rather a form of evasive behavior.

Adolescent↗
PubMed1978

[Social psychiatry of migrant workers (author's transl)].

A review of literature about psychic illness in migrant workers (with special reference to the situation in Europe) is presented, including the problems of incidence and prevalence, course of the illness, typical syndromes and treatment. Results concerning incidence and prevalence of psychic disease in migrant workers are contradictory and partly--for methodological reasons--of questionable quality. It cannot be take for granted, that migrant workers suffer more often from psychiatric disturbances than either of the two possible control groups: the populations of the emigration or immigration countries respectively. There are two high risk periods for migrants: shortly after the migration and after a longer period in the guest country. Differences between the migrant's culture and that of the immigration context (language, mythical beliefs, illness behavior) influence the manifestations of psychiatric syndromes. The following syndromes are typical for migrant workers: paranoid reactions, hypochondric-depressive syndromes, psychosomatic conditions and sexual neurosis. Special attention requests the treatment of migrant workers with psychiatric problems; the aspects of psychotherapy, accompanying social measures and the return as therapeutic measure are discussed. In the second part, a general frame of reference for the sociological analysis of the problem of migrant workers is presented. Reasons for the mass immigration of foreign workers to the industrialized countries of central Europe were the demand of labor force and the large gap in socio-economic development between the countries. In the immigration context, the foreign workers find themselves in the lowest social strata and numerous problems accumulate there. Empirical evidence for different sociological explanations of mental illnes of migrant workers ist presented: hypotheses of social selection vs. social causation (low socio-economic status, goal-striving-stress, culture-shock theory, theory of culture change and isolation hypothesis).

Adjustment Disorders↗
PubMed1978

[Social class and mental disorders (an empirical study in Zurich canton)].

The correlation of social class and diagnosis, therapy, mode of admission, frequency of hospitalization was tested in a population of 2103 inpatients of the two governmental and of two private mental hospitals of the Canton Zurich. The results fit to the correlations expected from the literature. The therapeutic procedures as far as reported in the case histories are mainly determined by the hospital type, not so clearly by the subject's social class. High educational status and psychotherapy are correlated. The correlation between social class and therapy is resulting of the class specific admission to one of the two hospital types. There was no sign that within one hospital patients of lower social class were placed at a disadvantage in regard to therapeutic procedures.

Educational Status↗
PubMed1977

Toward a new theory of dreaming.

A new Process Scoring System for dreams was developed and applied in an intensive single-S case study that spanned 5 1/2 years and 754 dreams. In it two hypotheses derived from a new transformative theory of dreams were tested. Both the transformation hypothesis, which holds that it is possible to shift from a symbolic to a directly expressive mode of dreaming, as well as the parallelism hypothesis, which holds that the expression of affect in dreams parallels the expression of affect in waking, were supported by the results. In contrast to Freud's analytic theory, which deals with content and interprets dreams as coded symbolic messages, our transformative theory focuses on dynamic dream processes and views dreams as pictures of feelings.

Adult↗
PubMed1977

A reapplication of the process scoring system for dreams.

The first application of the new Process Scoring System for dreams was made in an intensive longitudinal case study of 1 S over a 5 1/2 year period. In this second application, the dreams of a sample of 5 experienced Feeling Therapy patients were compared to those of 5 control Ss. As in the first study, considerable support was found for both the transformation hypothesis, which holds that it is possible to shift from a symbolic mode of dream behavior to a directly expressive one, and the parallelism hypothesis, which holds that the expression of affect in dreams parallels the expression of affect in waking and vice versa.

Dreams↗