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Biomedical subjects

J Białowas

Publications and source records attributed to J Białowas.

13 recordsLinked to original sources

Right-sided aortic arch.

Congenital abnormalities of the aortic arch arise due to a defect in the unilateral disappearance of arteries of the IVth and exceptionally of the IIIrd primary branchial arches and also of the appropriate sections of paired dorsal aortas. Apart from the cases of complete "situs inversus" and a double aortic arch, the following anatomical possibilities can be distinguished: A--a left-sided aortic arch with a properly established system of branches, B--a left-sided aortic arch with an aberrant right subclavian artery, C--a left-sided aortic arch with a retro-esophageal course and right-sided descending aorta or retro-esophageal course of the brachiocephalic trunk onto the right side, D--a right-sided aortic arch of the "symmetric" type usually coexisting with cyanotic congenital heart lesions, E--a right-sided aortic arch with a retro-esophageal bulge and an aberrant left subclavian artery, and F--a right-sided aortic arch with an aorta descending left-sidedly or brachiocephalic trunk going left-sidedly behind the esophagus. At the Department of Anatomy from 1945 to 1998, 1700 adult cadavers were examined. Throughout this time, one case of each of the types E and C and two cases of the type B were noted in the material. Regardless of the rare occurrence among adults (about 0.01%), the abnormal course of the aortic arch can be the reason for atypical clinical symptoms such as esophageal compression and dysphagia or insufficient cerebral blood supply.

Adult↗

Catecholamines in some hypothalamic and telencephalic nuclei of food deprived rats.

The influence of 48 h food deprivation on the levels of catecholamines was investigated in different hypothalamic and telencephalic nuclei of the rat brain. There were on changes in the levels of noradrenaline (NA) and dopamine (DA) in the lateral hypothalamic area, dorsomedial nucleus, medial preoptic area and in nucleus of diagonal band (septum). On the other hand we observed a statistically significant decrease of NA and DA in the ventromedial nucleus and the decrease of NA in the arcuate nucleus.

Animals↗

Hunger induced changes in the noradrenaline and dopamine contents in various nuclei of the limbic system in rats.

Teh effect of 48 hr food deprivation on noradrenaline (NA) and dopamine (DA) content in the dorsomedial, ventromedial and arcuate hypothalamic nuclei, in the anterior and posterior part of medial forebrain bundle, in the medial preoptic region, nucleus of diagonal band (septum), and in the central, medial and basal nuclei of the amygdaloid complex was investigated by radioenzymatic assay. It was found that starvation resulted in decreased NA and DA levels in arcuate and ventromedial nuclei, and increased DA content in the posterior medial forebrain bundle. A statistically insignificant increase of DA in the central amygdaloid nucl. was also observed.

Amygdala↗

The relationship between catecholamine levels in the hypothalamus and amygdala under influence of glucose overloading in hungry and sated rats.

The effect of intragastric glucose infusion (1.5 g per rat) to sated rats on the catecholamine content in the medial basal and lateral hypothalamic regions and in the nuclei of the amygdaloid body was investigated. The effect of glucose overloading on the noradrenaline (NA) and dopamine (DA) content in the ventromedial (VMH) and arcuate hypothalamic nuclei was also studied in rats deprived of food for 48 hr. Glucose administration to rats fed ad lib. resulted in an increase in NA in the VMH and a decrease in DA in the central nucleus of the amygdaloid body. In fasted animals glucose overloading partially reversed the changes of NA concentration in the arcuate nucleus produced by starvation, whereas in the VMH glucose was not effective in producing any changes of catecholamine content. Possible interrelations between the amygdala and hypothalamus in respect to the role of catecholamines in the regulation of food intake are discussed.

Amygdala↗

Effect of septal forebrain lesions on soluble fibrin monomer complexes in blood.

Soluble fibrin monomer complexes (FM) in blood were measured in septal forebrain lesioned rats on the 4th, 12th, 17th and 21st postoperative days by using the protamine sulfate-induced precipitation method. It was found that septal lesions resulted in a statistically significant increase of FM as compared to the control sham lesioned animals. This increase was positively correlated with heightened emotional reactivity induced by septal lesions. The results obtained suggest that damage to the septal forebrain area may activate the process of intravascular coagulation.

Animals↗

Carbohydrate components of serum proteins in the rats with lesions of the septal forebrain area and in the rats subjected to stress.

Bilateral electrolytic lesions of the septal forebrain area, surgical stress connected with production of sham lesions of the brain, or four-hour immobilization stress raised the level of neuraminic acid, aminosugars and the total content of carbohydrate components of glycoproteins in the rat serum. The observed effects were probably non-specific results of the pituitary-adrenal system activation developing independently of the causative factor in the observed experimental models. It is suggested by the fact that the effects obtained in the group of rats with lesions of the septal forebrain area did not differ from those observed of the sham lesioned animals.

Amino Sugars↗