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Biomedical subjects

J Berney

Publications and source records attributed to J Berney.

At least 37 records · Page 2Linked to original sources

[Acute subdural hematoma of arteriolar origin. Traumatic or spontaneous?].

Acute subdural hematomas are usually related to the rupture of a bridging vein with or without tearing of brain matter. In some instances the origin of the hemorrhage is due to the shearing of a cortical arteriole bleeding directly into the subdural space, generally after a minor head trauma. Ten cases were reviewed at Geneva's Neurosurgical clinic over a period of thirteen years (1973-1986). They represent less than 5% of all acute and subacute subdural hematomas treated during that period. Subdural hematomas of venous origin are usually encountered on previously normal brain whereas those of arteriolar origin are thought to result from the disruption of a small arteriolar knuckle adhering to the arachnoid and dura. While the majority of arteriolar hematomas reported here and in the literature are of traumatic origin, some are undoubtedly spontaneous. The clinical features of these hematomas are characterized by a high incidence of falsely localising motor signs, presumably due to the so called Kernohan's phenomenon. Their treatment requires a wide exposure, allowing identification and coagulation of the bleeding source located in most instances around the Sylvian fissure. Although a rare entity, the existence of arteriolar subdural hematomas must be emphasized, since any delay in their treatment may result in a dramatic outcome.

Adult↗

[Tumors of aqueduct of Sylvius. Presentation of 5 cases and review of the literature].

The authors reports their experience of 5 cases of intra- and peri-aqueductal tumors. With the exception of 1 case, a subependymoma of the aqueduct discovered at autopsy in a 77 year old woman, the 4 other patients (2 females and 2 males) are relatively young (respectively 14, 23, 14 and 26) at the time when they presented with signs of chronically raised intracranial pressure due to a triventricular hydrocephalus. One patient presented with a partial Parinaud's sign, but the focal and long tract signs were conspicuously absent in the other patients. The diagnosis of a space occupying lesion in the tectum mesencephali or in the aqueduct could only be ascertained with the recent use of M.R.I. The radiological work-up of the cases suggest that theses lesions, presumably of glial origin, are very slowly growing tumors. Four patients have been treated for their symptomatic hydrocephalus, but no treatment of the tumor has been proposed, as the clinical state and the images remain remarkably stable. (Mean duration of follow up from the time of shunting = 3.7 years, extremes = 1.5-8 years). A review of the literature shows that not more than 48 cases of tumors of the aqueduct have been reported. Because of the small number of such observations, there are, until now, no precise informations on the management of such cases to decide if the patient will benefit of an open or stereotactic biopsy associated with radiotherapy or if one can rely on serial clinical and radiological examinations. Further information on the long term follow up is needed.

Adolescent↗

[Epidemiological factors of lumbar disk herniation].

Two series of patients operated on for an herniated lumbar disc are studied retrospectively for the 484 cases of the first one and prospectively for the 289 cases of the second series. In both series, the large majority of the cases are aged between 30 and 60 years, about 60% are males and the body mass index (B.M.I.) is equally distributed among the patients and in the general swiss population of the same age. Only young men are heavier than the average. All the professions are represented among the patients, as the inactives or housewives, and not very different than in the normal population. Only in the first series heavy workers are considered as more frequent among the patients than in the population of Geneva. This is not confirmed by the second series. Sport is a possible factor implicated in the disease. It is suggested that heavy work or intensive sport in the adolescence can influence this problem. The incidence of herniated disc syndrome calculated from the second series in Geneva for people aged 20 to 69 is 62 cases/100,000/y, 75 for male and 51 for female. This is under the reality because some cases are operated in private clinics.

Adolescent↗

Surgical treatment of congenital fronto-orbitomalar asymmetries.

Congenital fronto-orbital asymmetries can be of various origin. Correction of these malformations, whether due to maldevelopment of the foetus or to a congenital tumour, generally require a combined intracranial and extracranial approach. In recent years, a working group of plastic surgeons and neurosurgeons in the French-speaking part of Switzerland have been particularly interested in these problems. Some of their results are presented here.

Bone Transplantation↗

[Late complications of closed injuries of the extracranial carotid artery. Apropos of 2 cases].

Closed injury with lesions of the great vessels of the neck are rare and usually due to high energy mechanisms with severe secondary deficit. 2 cases are reported, concerning young patients with relatively mild injury, neurological deficit not developing before 6 months after the traumatism in the first case and 8 months in the second. At this stage, the neurological signs were immediately severe, with cerebral infarction, leading to death in the first case. Pathological lesion of lesion of pseudo-anevrismal type, localised at the right carotid and subclavian artery bifurcation, was evidenced in the first case. In the second case, a bilateral intimal lesion of the carotid arteries at C1 level is illustrated on angiography. The mechanism of these lesions as well as the delayed manifestation of neurological deficits are discussed.

Adult↗

[Myelopathies in a context of generalized infection: myelitis or compression?].

Four patients with rapidly progressive tetraparesis in relation with skin or joint infection and septicemia are reviewed. Clinical signs of medullary compression was present in all cases, confirmed by neuroradiological examinations. However, all surgical approaches failed to demonstrate clear evidence of compression. Within three weeks, the neurological picture of severe tetraparesis had an excellent clinical evolution in all cases. One of the patients died after developing pulmonary complications: necropsy did not show any signs of compression. The difficulty of differential diagnosis between an infectious compressive surgical pathology and an inflammatory disease (acute transverse myelitis type) is emphasized, with review of literature.

Aged↗

[Hypercoagulability syndrome associated with cerebral lesions. Prospective study of coagulation during surgery of primary brain tumors (17 cases)].

Variations in hemostatic factors have been studied in 17 patients undergoing neurosurgical operations for intracerebral primary tumors. Clotting time (plastic and glass), recalcification time (Howell), plasma fibrinogen level, fibrin split products, partial thromboplastin time, Quick and platelet count were measured before and after the surgical procedure and several times during the following 24 hours. Hemostasis was significantly disturbed, with maximal hypercoagulability 2 hours after operation. In 3 patients, fundus examination showed occlusion of retinal vessels. In all cases the surgical trauma was relatively minor compared with severe cerebral contusion, but was nevertheless enough to disturb the measured parameters, which appear to be sensitive indicators for assessing the severity of cerebral lesions, especially in cases of contusion. A systematic fundus examination is also of diagnostic interest. The state of blood hypercoagulability may lead to disseminated intravascular clotting (DIC) and therefore prophylactic heparin therapy should be administered.

Blood Coagulation↗

[Study of the deterioration factors in adult patients with cranio-cerebral injuries who "talk and die"].

Between 1978 and 1984, the University Hospital of Geneva (Hôpital Cantonal Universitaire) received 46 head injured patients who "talked and died" after their brain insult. Only 14 of them had associated systemic lesions whilst two thirds of the series had an isolated head injury. Detailed review of the case records shows that death was preventable in a quarter of the cases. For 28 patients (60%), the factors contributing to death are avoidable or, at least, their management should be greatly improved. The diagnosis was confirmed by autopsy in 31 patients (67%).

Brain Injuries↗

Oligodendroglial tumors in childhood.

A series of 20 hemispheric tumors in children less than 16 years of age, over a period of 20 years, is presented. Among them, 8 were oligodendroglial tumors, a proportion well above the level reported in the literature. The World Health Organization (WHO) classification, which includes mixed oligoastrocytomas, in the oligodendrogliomas was used. This addition does not explain this unusually high proportion. Selection of cases and the correct histological diagnosis are probably important.

Adolescent↗

[Intracerebral cavernous angiomas].

8 cases of cavernous haemangiomas operated and histologically proven are presented. 5 patients (5/8) were admitted because of epileptic seizures, one patient (1/8) because of pure headache, another one because of a focal neurological defect and the last because of intracranial hypertension. Computed axial tomography is a sensitive procedure for detection of cavernomas. Of 7 cases examined by this technique, 7 (7/7) have shown a well circumscribed round or oval hyperdense nodule, with calcifications in 6/7 cases, a slight surrounding oedema in 3/7 cases and without mass effect, except if there is a visible hematoma at operation (2/8). After contrast administration, 5/7 malformations were enhanced and 2/7 displayed draining veins, a fact that we underline. The differential diagnosis includes a low grade calcified glioma, a thrombosed arterio-venous malformation, a venous angioma or an intracerebral hematoma. Surgical excision is the best treatment of these vascular malformations that bleed frequently, and improved all the patients in this series (8/8).

Adolescent↗

Lagophthalmos in acquired oculomotor synkinesis.

Two consecutive patients who exhibited classic signs of unilateral acquired oculomotor synkinesis demonstrated an inability to appose eyelid margins on the affected side, when attempting gentle closure of the eyes. In one patient, this occurred in conjunction with a unilateral upper eyelid crease on the affected side, and in the other patient it was associated with accentuation of the crease in comparison with that of the opposite side. Bilateral eyelid closure normally induces a contraction of the superior recti muscles. The lagophthalmos and accentuated upper eyelid crease observed in our patients when they attempted gentle eyelid closure presumably resulted from inappropriate coactivation of the levator palpebrae superioris muscle by impulses destined for the superior rectus muscle.

Adult↗

Macular reflexes in optic atrophy.

We investigated the annular reflex of the macula and the foveal reflex in 14 eyes with various degrees of optic atrophy by means of red-free fundus photographs. The patients ranged in age from 13 to 34 years (mean age, 25.9 years). We compared our observations with data obtained from 51 age-matched normal eyes. Optic atrophy was found to be associated with changes in the reflexes of the macular area. Alterations occurred in all eight eyes that had visual acuities of 20/50 or worse. Changes in the annular reflex of the macula were more significant in younger patients (less than or equal to 25 years of age) than in older patients. In the younger group, the annular reflex was blunt, distorted, and fragmented, and showed an irregular extension toward the foveal area, whereas in the old group it showed less specific attenuation. Fading of the foveal reflex was observed in both groups. Changes in the retinal reflexes of these patients result from alterations in the ganglion cell and nerve fiber layer and should be included among the signs of optic atrophy. They can help determine the extent of optic atrophy and can be useful clinical clues in children whose optic disks are difficult to examine. They should not be mistaken for signs of associated primary retinal disorders.

Adolescent↗

Spinal subarachnoid hematoma of spontaneous origin and complicating anticoagulation. Report of four cases and review of the literature.

Four cases of spinal subarachnoid hematoma are reported and three cases from the literature reviewed. Clinical presentation is characterized by a combination of back pain and meningismus and progressive compression of the spinal cord. Pathogenesis, diagnosis, and differential diagnosis are discussed. Information obtained from myelography was limited, and two patients underwent operation without it. Prognosis for functional recovery is poor unless decompression is performed at an early stage.

Adult↗