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Biomedical subjects

J Benz

Publications and source records attributed to J Benz.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Gynecologic cancers: preventive examinations and their limits. An analysis of the current staging and percentage distribution based on 2,612 cancers of the 1 January 1983 to 25 November 1985 cumulative statistics of the Society of Swiss Gynecologic Clinics].

An overview of the stages and age distributions is given for 2612 invasive genital and 1237 breast cancer cases, called from the data bank, compiled by the Swiss working group of the departments of gynaecology and obstetrics and consisting of 172,399 cases (1983-1985). The general over-representation of advanced and more therapy-resistant cancer stages (exception: corpus cancer) and their high incidence in advanced menopausal age, still characterise the present, all but satisfactory condition. Progress in the treatment of genital and breast cancers can be achieved only through improved early diagnosis with preventive examinations, without a limitation placed on age.

Breast↗
PubMed1986

[External version of breech presentation--a possibility for lowering the rate of cesarean section and infant morbidity].

Between 1979 and 1985 a total of 8641 children were born at the gynecological clinic in Winterthur, 388 of them (4.5%) from breech presentation. All of these were evaluated with regard to external version, and conditions for an attempt at version were satisfied in 97 cases. The principal prerequisite was a gestational age of at least 37 weeks. External version was accomplished in 39 of the 97 cases (40.2%). Complications encountered were drops in fetal heart tone or bradycardias in 26 cases (26.8%); the attempt at version was abandoned for this reason in 22 cases. In one case premature detachment of the normally implanted placenta occurred 6 days after successful external version, and in one case an emergency cesarean section had to be performed owing to persistent bradycardia. In a further case intrauterine fetal death was established 18 hours after successful version on the basis of an absence of fetal movement, though no cause of death could be found. Among the 39 cases in which version was successful a cesarean section was only necessary in one (2.5%), as opposed to 21 in the 58 cases (36.2%) in which the attempt at version failed. Neonatal fetal condition (Apgar score and umbilical blood gas analysis) revealed that neonates born from vertex presentation are subject to very considerably less stress. The international literature is discussed and compared. It is found that there has been a change of trend from a tendency to reject external version in the 1970s to a majority favoring it in the 1980s.(ABSTRACT TRUNCATED AT 250 WORDS)

Breech Presentation↗
PubMed1984

[Lowering the cesarean section rate by exclusion of cardiotocographically suspected acidosis using fetal blood gas analysis].

In 871 deliveries out of a total of 3980 effected during 1980-1982 at the Winterthur Gynaecological Hospital, we found it necessary to perform one or several microanalyses of blood (blood gas analyses) sub partu. Among these, we found retrospectively that in 22 cases the microanalysis of the blood gas had prevented us from performing caesarean section which would have seemed necessary if we had relied on the cardiotocographical findings alone. Micro-analysis of blood gas made it possible to exclude the presence of pre-acidosis or acidosis which would have made Caesarean section imperative; in all these cases, normal delivery via the vagina was achieved, and in no case did this result in severe acidosis. All newborn had a 5-minute Apgar score of 7 and higher. We can conclude from these results, therefore, that the indication for an immediate termination of delivery via Caesarean section should not depend solely on a pathological cardiotocogram; the final decision should be arrived at only after micro-analyses of blood gas have confirmed the presence of foetal pre-acidosis or acidosis.

Acidosis↗
PubMed1980

Detection and partial characterization of activity of chlorophyll synthetase in etioplast membranes.

The esterification of chlorophyllide a was investigated an irradiated etioplast-membrane fractions ('broken etioplasts') from oat seedlings (Avena sativa L.). As a substrate, [1(-3)H]geranylgeraniol and its monophosphate and diphosphate derivatives were prepared by chemical synthesis. Geranylgeraniol and its monphosphate derivative are incorporated into chlorophyll only in the presence of ATP whereas the diphosphate derivative is incorporated also without ATP. The yield of esterified chlorophyll is 80-90% of chlorophyllide with saturating substrate concentrations. The term 'chlorophyll synthetase' is used to describe the enzyme activity which is different from chlorophyllase. Other substrates are phytol and farnesol either with ATP or as the diphosphate derivatives. The relative specificity of 'chlorophyll synthetase' for thse substrates is geranylgeraniol:phytol:farnesol = 6:3:1. In these experiments in vitro, a new chlorphyll esterified with farnesol was detected which does not occur in intact plants. Geraniol and n-pentadecanol are no substrates for the enzyme. Protochlorphyllide which is present in non-irradiated etioplast membrane fractions is not esterified under the same conditions.

Carbon-Oxygen Ligases↗
PubMed1975

[Stimulation thresholds of implanted cardiac pacemakers (author's transl)].

The Vario-pacemaker EM 169 makes it possible, without additional equipment, to determine stimulation thresholds after implantation. A study on 149 patients with implanted pacemakers demonstrated characteristic temporal changes in stimulation threshold: starting with a mean value of 0.57 +/- 0.18 V on implantation, a maximal value of 1.93 +/- 0.66 V to 2.00 +/- 0.58 V was reached between the eighth and fourteenth days. The threshold remained constant at this level for a time and then oscillated downwards from the third month onward to values of about 1.55 to 1.70 V. However, when the electrode was dislodged or dislocated, there was in most instances an increased threshold and, during the same test, variations in threshold values. In general, electrode dislocation could be diagnosed in time with the vario-principle, before failure of stimulation at maximal voltage of 5.2 V. In 17 of 140 cases of implantation (12%) the electrode position had to be revised: in 13 electrode dislodgement was diagnosed even before failure of stimulation at full voltage of 5.2 V. The reported results suggest that occurrence of an exit block is always due to electrode dislodgement. In addition, it is clear retrospectively that in most cases of dislocation primary fixation of the electrode in the trabeculations of the right ventricle had been unsatisfactory.

Electric Stimulation↗