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Biomedical subjects

J Bellinger

Publications and source records attributed to J Bellinger.

161 records · Page 9Linked to original sources

Transfer of prostaglandins to the fetus after prostaglandin E2 vaginal pessary administration.

The kinetics of prostaglandins instilled vaginally has been studied in the maternal and fetal circulations, with observation of changes in the stable prostaglandin E2 metabolite 11-deoxy-13,14-dihydro-15-keto-11 beta,16-cyclo-prostaglandin E2. After the administration of prostaglandin E2, 10 mg in a wax-based pessary, concentrations of prostaglandin E2 metabolite in the maternal circulation increased; concentrations in the fetal circulation were higher than those in control subjects. There was a positive correlation between levels found in the fetal and maternal circulations. The implications of these preliminary findings are discussed in relation to the consequences of the use of vaginally administered prostaglandin E2 for cervical ripening and labor induction.

Abortion, Induced↗

In vitro fertilisation in a small unit in the NHS.

In vitro fertilisation is one of the most effective new treatments for infertility, but financial restrictions have made it impossible for it to be widely carried out in the National Health Service. We report on the establishment of a small, largely self funded, unit that was set up with the help of the local health service management. All cycles are programmed so that most work is carried out during the working week; oocyte recoveries are performed as outpatient procedures without general anaesthesia and guided by ultrasound. Roughly a tenth of treatment cycles and roughly a fifth of embryo transfers resulted in a clinical pregnancy.

England↗