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Biomedical subjects

J Beckmann

Publications and source records attributed to J Beckmann.

90 records · Page 5Linked to original sources
PubMed1976

Effects of D-glyceraldehyde and 3-o-methylglucose upon fluorescence of reduced pyridine nucleotides from perifused isolated pancreatic islets.

In perfused pancreatic islets, the fluorescence of reduced pyridine nucleotides was recorded continuously, D-Glyceraldehyde (5 mM) or 3-o-methylglucose (27.5 mM) never caused a net fluorescence increase. Since stepwise changes of the D-glucose concentration between 0 and 20 mM always induced a fluorescence increase, it is concluded that glucose on the one hand and glyceraldehyde or 3-o-methylglucose on the other hand cause different metabolic states in pancreatic islets.

Animals↗
PubMed1976

Inhibition o'f insulin release by cyproheptadine: effects on 3',5'-cyclic-AMP-content and 45Ca-accumulation of incubated mouse islets.

Cyproheptadine (1, 10 and 100 muM) significantly reduced insulin release from isolated mouse islets in response to glucose. In contrast, 1 mM cyproheptadine induced a large release of insulin into the incubation medium probably due to islet cell damage, since the islets had lost a considerable amount of their protein content. 3',5'-cyclic-AMP-levels of the islets were not significantly affected by 10 muM cyproheptadine in the presence as well as in the absence of theophylline (10 mM). As the inhibitory effect of cyproheptadine on insulin release was correlated with reduced accumulation of calcium-45, the agent may inhibit insulin release by interfering with the calcium handling of the beta-cell.

Animals↗
PubMed1976

[Education in medical psychology--goals, contents and means].

Education in medical psychology is now being extended to include 56 hours at the Faculty of Medicine at Copenhagen University. 26 hours are devoted to lectures during the first term, and a one-week intensive course comprising 30 hours is given during the sixth term. The training concentrates on problem solving, and studies comprise, among other things, TV-instruction, case histories, and group and panel debates.

Curriculum↗
PubMed1975

Course in basic sexology for medical students.

The present article describes the pilot course in basic sexology for medical students. The duration of the course was 5 days (35 hours). The themes-sex and gender, sexual physiology, contraception, sexual inadequacy, sexual deviations, and sexual counselling-were approached from many different angles. The teaching procedure comprised lectures, group work, and group discussions, internal television, films, plenary discussions, and debates. The course was evaluated by means of the sex knowledge and attitude test (SKAT) given before and after the course. Furthermore an evaluation was given by the students, by a professional teacher, and by a paramedical evaluator at the end of the course. The results showed significant changes in attitudes and knowledge.

Attitude of Health Personnel↗
PubMed1975

14C-glucose and 35S-metabolism of pig epiphysial cartilage and its variations after osteotomy.

On in vitro incubation of articular and epiphysial cartilage of the ulna of the domestic pig 70 to 80 per cent of [U-14C] glucose was metabolised to 14C-lactate, but cartilage of the epiphysial plate produced up to five times as much 14C-CO2 as articular cartilage, and the specific radioactivity of 14C(or 35S)-chondroitin 4(6)-sulphate isolated from epiphysial cartilage (following 35S-sulphate incorporation) was about twice as high as that of articular cartilage. Six weeks after an osteotomy on both sides of the proximal epiphysial plate of the lift ulna, the glucose uptake, lactate production, and the specific radioactivity of the glycosaminoglycans displayed no significant differences when compared with those of the corresponding epiphysial plate of the control right ulna, whereas a 50 per cent increase in the oxidation of 14C-glucose to 14C-CO2 was observed.

Animals↗
PubMedDate not supplied

Limb girdle muscular dystrophy type 2A (CAPN3): mapping using allelic association.

Recently a graphical study of linkage disequilibrium around the CAPN3 locus failed to refine the 1.3-Mb interval suggested by haplotype sharing. On the contrary, the Malecot model as implemented in the ALLASS program maps CAPN3 within 3 kb of its true location (23 kb from the locus midpoint), overcoming identified problems with small samples, interrelated sibships, and short duration.

Alleles↗