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Biomedical subjects

J Becker

Publications and source records attributed to J Becker.

At least 325 records · Page 18Linked to original sources
PubMed1978

[Experimental study on the effect of ephedrine in an anger-provoking situation].

The purpose of this study was to investigate the effects of ephedrine-induced sympathetic arousal on emotional reactions in an anger-provoking situation. The effects of ephedrine were compared with a placebo condition while the effects of the anger-situation were compared to a neutral control situation. 60 male students were randomly assigned to one of the four conditions of the two-factor design. The dependent variables were various peripheral-physiological measures and self rating of physical and emotional states. Both independent variables were found to be effective. Contrary to expectation, ephedrine decreased subjective emotional reactions to the anger-provoking situation rather than increase it. Methodological problems and possible conclusions about the role of sympathetic arousal for emotional reactions are discussed.

Adult↗
PubMed1977

Comparison of the cycloheximide and food satiation effects on a discrimination task.

The effects of intraventricular cycloheximide (CHX) pretreatment were examined on the ability of rats to recall a light position discrimination task. The CHX pretreatment used inhibited brain protein synthesis at the time of training by 71%. Following treatment with CHX the animals demonstrated no retention of the task 18 hr later. Free feeding for 24 hr prior to treatment with cerebro-spinal-like fluid (CSF) produced similar effects as CHX. It is proposed that the amnesic effect of CHX in this behavioral paradigm may be a nonspecific action resulting from decreased motivation. Both the CHX-treated and satiated animals exhibited low responding levels during training, despite comparable behavioral activity levels for the CHX- and CSF-treated groups.

Animals↗
PubMed1976

Torsion of a visceroptosed spleen.

Torsion of the pedicle of a visceroptosed spleen, a rare condition, was diagnosed preoperatively in a 4-year-old girl, with the aid of history, physical examination, blood smear findings, splenic scans with technetium Tc 99m sulfur colloid, and selective angiography. A splenectomy was performed, and the child made an uneventful recovery. This case report illustrates some of the diagnostic and therapeutic considerations pertaining to torsion of the spleen.

Child, Preschool↗
PubMed1975

[Centronuclear myopathy with autosomal dominant inheritance(author's transl)].

For the first time in Germany cases of a "centronuclear myopathy" are described in a 14-year-old boy and his 18-year-old sister. First symptoms in both patients appeared at 4 to 5 years of age with a "sleepy facial expression", clumsy gait and rapid fatigue. Within few years the disease progressed to generalized muscle weakness and atrophy, ptosis, ophthalmoplegia externa and areflexia. Weakness and atrophy were most pronounced in the distal muscles of the lower extremities. Both patients were free of epilepsy and the EEG recordings were normal. Motor and sensory nerve conduction velocities were normal. Repetitive stimulation of nerves revealed a normal transmission from nerve to muscle. Muscle biopsy showed a type I muscle fiber hypotrophy and a type II muscle fibre hypertrophy in addition to a predominance of type I fibres. Both fibre types showed central nuclei, sometimes appearing as chains in longitudinal sections. In most cells with central nuclei there persists a very small pericentral zone free of myofibrils but with increased activity of oxidative enzymes and phosphorylase. 2--3% of muscle fibres in cross sections showed a decreased of absent enzyme activity in the most peripheral fibre zone. Electron microscopy showed evidence of a centrally distinct myofibrillar disintegration. The father of both children had a ptosis at least from the 20th year of age. 5 years later generalized progressive muscle atrophy was recorded. Aged 51 years he died of pneumonia. Though not proved most probably the father suffered from the same disease as the children, pointing to an autosomal dominant inheritance in this family. The disease, according to the literature, seems to be genetically heterogeneous. The clinical picture seems to be independent of the mode of inheritance. Our patients showed a relatively rapid progression of symptoms. Pathogenetically the "centronuclear myopathy" may result from a disturbance of correlated nerve-muscle structures starting during early fetal life.

Adolescent↗
PubMed1975

The future of medical eduction: forecast of the Council of Deans.

This paper reports the results of a Delphi probe of the perceptions of medical school deans regarding the most significant changes in medical education and in the health care system which they expect to influence medical education over the next 20 years. The study, conducted in the first quarter of 1974, included an analysis of 54 potential changes distilled from over 440 suggestions. A composite view of the probability of occurring, impact on the system and percentage of deans favoring the change are presented. In general, the future is believed to hold more positive changes than negative ones, and those most likely to occur will come about in the near term. The results disclose few surprising conclusions but provide a structural description of areas of consensus and disagreement among deans.

Delivery of Health Care↗
PubMed1975

Coccidioidal synovitis of the knee.

Four patients are described with documented coccicioidal synovitis of the knee joint. In two of them, no previous diagnosis of coccidioidomycosis had been made prior to diagnosis of coccidioidal synovitis. The other two had active disease after courses of amphotericin B administered both parenterally and intra-articularly for disseminated coccidioidomycosis and coccidioidal synovitis. After synovectomy and limited parenteral amphotericin B therapy, none of the four patients whos evidence of active synovial infection two to seven years later. Synovectomy appears to be an important aspect of the optimal therapy of coccidioidal synovitis of the knee, and when performed, the parenteral dosage of amphotericin B can be limited. Intra-articularly administered amphotericin B is also advocated when possible.

Adult↗