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Biomedical subjects

J Baum

Publications and source records attributed to J Baum.

At least 235 records · Page 13Linked to original sources
PubMed1979

The absence of differences in cellular immunity in elderly individuals with and without delayed local cutaneous reactions to influenza vaccine.

Two groups of elderly subjects who received bivalent influenza virus vaccine were identified. Those in Group I manifested marked local reactions, suggestive of delayed hypersensitivity reactions, whereas those in Group II, matched with Group I for vaccine preparation, had no cutaneous reactions. In vitro assays of immune function were performed on pairs of subjects from the two groups and included serum immunoglobulin and complement levels, antibody response to vaccine, lymphocyte transformation to mitogens (phytohemagglutinin, pokeweed mitogen and concanavalin A) and antigens (streptokinase-streptodornase, influenza virus vaccine antigens and multiple mixed lymphocytes), and polymorphonuclear leukocyte chemotactic responsiveness. There was no demonstrable correlation between delayed local cutaneous reaction and preservation of in vitro cell-mediated immune function in these elderly individuals.

Age Factors↗
PubMed1979

Marked differences between pigmented and albino rabbits in the concentration of clindamycin in iris and choroid-retina.

The concentrations of clindamycin were significantly higher in iris and choroid-retina or pigmented rabbits than in those of albino rabbits after subconjunctival injection. Equilibrium dialysis experiments showed no affinity of clindamycin for synthetic melanin or for collagenase digests of pigmented tissues. In contrast, strips of iris and choroid-retina took up clindamycin rapidly from solution, achieving concentrations substantially higher than those in the medium. Uptake by tissue strips was not influenced by temperature (4 C vs. 37 C), cyanide, or ouabain. However, N-ethylmaleimide, which reacts with sulfhydryl groups, decreased the tissue-to-medium ratios by about 50% for both albino and pigmented choroid-retina. Even in the presence of this inhibitor, the ratio for pigmented tissues remained higher than that for albino specimens. These findings suggest the existence of one, or possibly two, mechanisms of energy-independent accumulation of clindamycin by pigmented ocular tissues: one may relate to protein sulfhydryl bonds that are present in both breeds; the other may involve the pigmentation apparatus.

Animals↗
PubMed1979

The use of penicillamine in the treatment of rheumatoid arthritis and scleroderma.

The use of penicillamine in the treatment of rheumatoid arthritis and scheroderma is reviewed. Much of the worlds literature was collected including both open studies and control studies. Both types with over 1,300 patients in the open trials and as one would expect, a smaller group in the control trials, showed about 64 percent of the patients having good results. Side effects range from one quarter to one third of the treated patients. This seems to show penicillamine as an effective drug for the treatment of rheumatoid arthritis though with a multiplicity of side effects. Its use in the treatment of scleroderma is still uncertain. Because of the rarity of the disease the number of patients treated has been small and the data is conflicting.

Adult↗
PubMed1979

Emergency hospital care: issues of treatment and liability.

Increased utilization of hospital emergency rooms, and a departure from traditional physician-patient relationships, have resulted in increased litigation. Risks to hospitals can be minimized if certain policies are pursued.

Emergency Service, Hospital↗
PubMed1979

[Combined-electrostimulation-hypalgesia in surgery of the lumbar vertebral column. A tentative evaluation of this method (author's transl)].

A new concept of anaesthesia in patients undergoing operations of the lumbar vertebral column is presented. Electrostimulation of four auricular acupuncture points is combined with controlled ventilation of nitrous-oxide oxygen mixture. This combination is comparable to similar anaesthesia procedures of other operative fields. In 30 patients the anaesthesia was performed as a "combined electrostimulationhypalgesia". In a control study of 30 similar patients a mixture of nitrous-oxide and oxygen only was used. For 120 min systolic and diastolic blood pressure as well as heart rate of both groups are measured and compared. The postoperative state as well as individual data from the patients are included in the investigation. The analgesia established by "combined electrostimulationhypalgesia" seems to be based essentially on the effect of nitrous-oxide as well as premedication, induction of anaesthesia, relaxation and kind of ventilation. Electrostimulation of auricular acupuncture points seems to induce stabilisation of the circulatory system. On account of our findings the relevance of electrostimulation in this method of anaesthesia must be judged very critically.

Acupuncture Therapy↗
PubMed1979

[Characteristics of electrostimulation with the multi-purpose therapy apparatus 71-3 for electroacupuncture analgesia].

The stimulating impulses employed in electroacupuncture analgesia are of widely differing character and strength. Experiences with the Chinese impulse generator MPTA 71-3 clearly show the necessity to determine the performance of the generator and to measure and record the strength, configuration and frequency of the electrical impulses employed. A simple equipment for measuring these factors is described. The apparatus makes it possible to record the character and type of the stimuli and to compare different techniques of stimulation.

Acupuncture Therapy↗
PubMed1979

The effect of immunization on polymorphonuclear leukocyte chemotaxis in influenza.

Challenge of human subjects with influenza virus produced a significant fall in the chemotaxis of polymorphonuclear leukoyctes (PMN's) obtained from their peripheral blood. This was seen by 3 days with some return toward normal function at 7 days but with a persistent defect still found at 20 days after challenge.

Antibodies, Viral↗
PubMed1978

Efficacy of penicillin G, cefazolin, and gentamicin in M-K medium at 4 degrees C.

Corneal-scleral shells are routinely stored in McCarey-Kaufman (M-K) medium at 4 degrees C. Antibiotics are added to the medium to suppress bacterial growth. We examined the antibacterial activity of penicillin G potassium, 100 microgram/ml, cefazolin sodium, 100 microgram/ml, and gentamicin sulfate, 20 microgram/ml against test organisms in M-K medium at 4 degrees, 23 degrees, and 37 degrees C for periods up to 18 hours. Within the limits of the experimental conditions, none of the antibiotics used could be relied on to sterilize an inoculum of sensitive bacteria in M-K medium at 4 degrees C, the recommended storage temperature.

Anti-Bacterial Agents↗
PubMed1978

Goldenhar's syndrome.

We present a report on 16 patients with Goldenhar's syndrome. The criteria we required for the diagnosis of Goldenhar's syndrome consisted of an eye abnormality (lipoma, lipodermoid, epibulbar dermoid, or upper eyelid coloboma) associated with ear, mandibular, or vertebral anomalies (two of the three). Although Treacher Collins' syndrome can be easily differentiated from Goldenhar's syndrome, the differences between Goldenhar's syndrome and hemifacial microsomia are more difficult to delineate.

Abnormalities, Multiple↗
PubMed1978

Psychosocial factors in juvenile rheumatoid arthritis.

A detailed survey of 88 children with juvenile rheumatoid arthritis (JRA) was made in an attempt to elucidate characteristics that may participate in the etiologic mechanism. Data from a random pediatric population from the same geographic area were also included for comparisons. The most striking findings were psychosocial factors. Children whose parents were unmarried as a result of divorce, separation, or death comprised 28.4% of the JRA population, compared to 10.6% of the comparison group. In addition, adoption occurred three times more often in the JRA population. Fifty-one percent of these events (divorce, separation, death, or adoption) occurred near the date of onset of the disease.

Adolescent↗
PubMed1978

Intraocular penetration of gentamicin after subconjunctibal and retrobulbar injection .

We compared the ocular penetration of labeled with radioactive carbon gentamicin in squirrel monkeys after subconjunctival and retrobulbar administration. In both normal and infected (Staphylococcus aureus endophthalmitis) eyes, high concentrations of drug were achieved in the sclera and choroid-retina by both routes, while corneal levels were markedly higher after subconjunctival injection than after retrobulbar injection. Regional variations in concentration were evident in these tissues; the highest levels were clustered about the site of injection. Aqueous humor concentrations were lowest in the group with normal eyes treated by the retrobulbar route; vitreous humor levels were extremely low in normal eyes injected subconjunctivally. These data differ from those in rabbits, especially with regard to penetration of the vitreous humor of normal eyes. Interspecies differences were less marked in inflamed eyes. The two species were similar in demonstrating maximum access to the cornea and aqueous humor with subconjunctival injection, and equivalence of the two routes in penetrating the vitreous humor of the inflamed eyes.

Animals↗
PubMed1978

Excretion of gentamicin in rabbit tears after subconjunctival injection.

We subconjunctivally, injected gentamicin, in a dose of 10 mg, into normal and inflamed (Staphylococcus aureus endophthalmitis) rabbit eyes in which the nasolarcrimal ducts had been blocked. We retrieved approximately 10% of the dose of drug in the tears, the majority in the first 30 minutes. The difference in lacrimal excretion of the drug between normal and inflamed eyes was not significant. Higher concentrations of gentamicin found in the ocular tissues of normal eyes than inflamed eyes cannot be attributed to loss in the tears.

Animals↗