Search PubMed⌕ Search

Biomedical subjects

J Bass

Publications and source records attributed to J Bass.

120 records · Page 7Linked to original sources
PubMed1977

The effect of hyperthermia on aqueous humor dynamics in rabbits.

Hyperthermia increased intraocular pressure (Po) by approximately 5 mm Hg in rabbit eyes. This increase was not associated with changes in plasma osmolarity, blood lactate, or pH. Episcleral venous pressure (Pv) decreased from a baseline of 11 +/- 1 mm Hg(mean +/- SEM) to 8 +/- 1 mm Hg after one hour of hyperthermia. Outflow facility (c) as measured by tonography remained unchanged. Aqueous humor flow [c(Po - Pv)] as estimated by tonography increased by about 126%. The elevation of intraocular pressure was not prevented by aspirin pretreatment nor altered by unilateral optic nerve transection.

Animals↗
PubMed1977

Acidosis, alkalosis, and aqueous humor dynamics in rabbits.

Systemic acidosis induced by intravenous administration of hydrochloric acid lowered intraocular pressure in unanesthetized rabbits. Aqueous humor flow was reduced by approximately 50%, as measured by the iodide method and as calculated from tonographic data. Outflow facility, episcleral venous pressure, plasma osmolality, blood pressure, pulse, and body temperature were not altered by systemic acidosis. Systemic alkalosis induced by intravenously administered sodium bicarbonate was associated with an increased intraocular pressure. Aqueous humor flow following systemic alkalosis was increased by approximately 100%, as measured by the iodide method and as calculated from tonographic data. Alkalosis was not associated with alterations in outflow facility, episcleral venous pressure, plasma osmality, blood pressure, pulse, or rectal temperature.

Acidosis↗
PubMed1976

Paracecal hernia: case report and review of the literature.

A case of paracecal hernia successfully treated operatively is described. Review of the literature revealed 145 previously reported cases. Our case is added. Pertinent anatomy predisposing to paracecal hernia is reviewed. Roentgenographic signs of paracecal hernia are presented. Clinical signs and symptoms are discussed.

Cecal Diseases↗
PubMedDate not supplied

Human tumor suppressor p53 and DNA viruses.

Human tumor suppressor protein p53 plays a major role in the cell cycle, orchestrating a number of important genes involved in cell-cycle control and apoptosis, and seems to be one of the most important molecules protecting cells from malignant transformation. Mutations in the p53 gene are observed in about 50% of primary tumors, inducing defective p53 protein no longer capable of binding DNA and of activating transcription. Certain DNA viruses are thought to act in a similar way and may also contribute to the progression of invasive cancer in infected tissue. One of the most effective strategies employed by these viruses is the inhibition of p53 protein by interaction with viral oncoproteins, implying a direct but also an indirect role of these viruses in the impairment of p53 structure and function. This article provides a summary of current knowledge concerning p53 tumor suppressor protein and reviews the different mechanisms adopted by different DNA viruses in undermining p53 function.

Cell Cycle↗
PubMedDate not supplied

Effects of enteral tube feeding on the absorption and pharmacokinetic profile of carbamazepine suspension.

In a randomized, two-period crossover clinical study, eight normal male volunteers received two separate 500-mg doses of carbamazepine (CBZ) suspension 1 week apart. One dose was administered orally after an overnight fast, and the other was administered by nasogastric feeding tube during a continuous enteral feeding infusion. Serial serum CBZ concentrations were determined by high-performance liquid chromatography (HPLC) to assess the effects of the enteral feeding on CBZ absorption. Noncompartmental methods were used to estimate pharmacokinetic data. One volunteer experienced a mild hypersensitivity reaction after his first CBZ dose and was withdrawn from the study. The other subjects tolerated both doses very well, although most experienced mild drowsiness or lightheadedness. Serum CBZ concentrations were lower during enteral feeding administration, but the differences were statistically significant only at 8 h (p = 0.044). Changes in pharmacokinetic data were not significant, although the decrease in maximum serum concentration approached significance (p = 0.052). The relative bioavailability of CBZ suspension with enteral feeding administration was 90.1% of that during fasting. There was a strong correlation between CBZ dose (mg/kg) and Cmax after oral administration (r = 0.97, Y = 1.88X - 4.49, p less than 0.001) but not during enteral feeding administration. Although absorption of CBZ suspension was generally slower and slightly diminished during nasogastric feeding, this interaction may lessen unwanted side effects.

Absorption↗
PubMedDate not supplied

Hemodynamically significant suture line obstruction immediately after heart transplantation.

Mechanical complications after heart transplantation are uncommon. We describe a case of hemodynamically significant suture line obstruction that was recognized immediately after heart transplantation using transesophageal echocardiography. Transesophageal echocardiography has proved to be a powerful tool in recognizing mechanical complications in the early posttransplant period.

Adult↗
PubMedDate not supplied

Long term comparison of fresh arterial allografts and autografts for coronary artery bypass in dogs.

Femoral artery grafts were anastomosed end-to-end to the left internal mammary artery proximally and end-to-side to the circumflex coronary artery distally in 21 adult mongrel dogs. Fourteen dogs received allografts and seven received autografts. All autografts studied from one to 11 months were patent. Eleven of the fourteen homografts studied from one to thirteen months were occluded. Histologically, extensive interstitial edema and leukocytic infiltration with subintimal fibrosis and thrombotic occlusion were seen. This study shows that fresh arterial autografts have excellent long term patency, but that most arterial allografts have early thrombotic occlusion.

Animals↗