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Biomedical subjects

J Barzilay

Publications and source records attributed to J Barzilay.

At least 37 records · Page 2Linked to original sources
PubMed1987

Predictive value of the resting electrocardiogram for Mobitz type I atrio-ventricular block on Holter monitoring in Israeli air force personnel.

During 1981-1984, a total of 52 airpersonnel had 24-h continuous ambulatory electrocardiographic (ECG) monitoring at the Israel Air Force Aeromedical Center because of an incidental finding of a first or second degree atrio-ventricular block on a resting 12-lead ECG. There were 230 other airpersonnel without AV block on the resting ECG monitored during the same period. Altogether 17 cases of second degree Mobitz type I (Wenckebach) block were identified. Mobitz type I was detected on Holter monitoring in 2 (0.9%) of the 230 cases with a normal PR interval on the resting ECG, in 6 (15.4%) of 39 cases with a PR interval of 0.22-0.25 s, in 5 (55.5%) of 9 cases with a PR interval of 0.26 s or more, and in all 4 cases with Mobitz type I on the resting ECG. It is concluded that the PR interval on the resting ECG may be useful in predicting an intermittent Mobitz type I AV block on Holter monitoring.

Aerospace Medicine↗
PubMed1987

The predictive value of the body mass index for systolic blood pressure 12-15 years later in young air force personnel.

The records of 719 male air force personnel, aged 18-30 in 1968, were searched for the results of the systolic blood pressure (SBP), and height and weight examinations at entry in 1968 and after 12-15 years follow-up. The body mass index (BMI = weight/height2) was calculated and an elevated value was defined as one in the upper quintile. An elevated blood pressure, defined as an SBP greater than or equal to 140 mm Hg, was found on follow-up in 4.7% of the entire cohort, in 6.0% (4/67) of those with an elevated SBP and a normal BMI at entry, in 10.2% (12/117) of those with a normal SBP and an elevated BMI at entry, and in 20.0% (7/35) of those with both elevated BMI and SBP greater than or equal to 140 mm Hg at entry. Of those with a normal SBP and BMI at entry, 2.2% (11/500) had an elevated SBP on follow-up. We conclude that BMI in young men can predict SBP 12-15 years later, and that this predictive value is at least as high as that of the resting blood pressure.

Adult↗
PubMed1987

Value of three annual blood pressure determinations in young adults as a predictor of elevated systolic blood pressure 15 years later.

The records of 726 male air force personnel aged 18 to 34 years in 1968 were searched for the results of examination of the systolic blood pressure (SBP) in 1968 and during the following 15 years ending in 1983. An elevated recent blood pressure (BP), defined as an SBP greater than or equal to 140 mm Hg on two or more of the last three follow-up examinations, done 13, 14, and 15 years after entry, was found in 3.2% of the cohort. An elevated recent BP was found in 12% of those with an SBP greater than or equal to 140 mm Hg on the first examination, in 31.7% (13 of 41 individuals) of those with an SBP greater than or equal to 140 mm Hg on two or more of the three initial annual examinations, and in 46.2% (6 of 13 men) of those with an SBP greater than or equal to 140 mm Hg on all three initial examinations. It is concluded that three annual determinations of SBP are better predictors of elevated SBP than a single causal BP measurement on entry. Still, their predictive value remains limited; 49% of those with an SBP greater than or equal to 140 mm Hg on two or more of the three initial annual examinations had a normal SBP on all of the last three annual examinations.

Adolescent↗
PubMed1986

Carcinoma of the nasopharynx. An analysis of 91 cases and a comparison of differing treatment approaches.

Ninety-one patients with malignant epithelial tumors of the nasopharynx seen in our department from 1970 to 1982 were evaluated. The 5- and 10-year actuarial survival rates were 62.0% and 42.0%, respectively. Patients seen from 1970 to 1979 were treated by radiotherapy to the primary site and upper neck, the lower neck being irradiated only in instances of massive disease. Those treated from 1980 to 1982 received elective irradiation of the whole neck, as well as adjuvant chemotherapy (consisting of cyclophosphamide, methotrexate, and either 5-fluorouracil or bleomycin) for 6 to 12 months after completion of radiotherapy. Comparison of 3-year actuarial survival (61.4% versus 83.3%) and disease-free survival (49.7 versus 77.0%) rates show significantly improved results (P less than 0.05) for those receiving combined therapy. In addition, significantly fewer (P less than 0.05) distant metastases appeared in the combined therapy group at 18 months. A retrospective analysis comparing those patients who received full-neck irradiation and adjuvant chemotherapy with those who received full-neck irradiation alone showed a significantly improved survival (P less than 0.02) and disease-free survival (P less than 0.05) for those patients with undifferentiated carcinomas, including lymphoepitheliomas, who received adjuvant chemotherapy.

Actuarial Analysis↗
PubMed1986

Correlation of Fc gamma receptors on peripheral blood mononuclear cells and survival in patients with metastatic breast cancer.

Patients with carcinomas have elevated levels of Fc receptors for IgG (Fc gamma R) on their peripheral blood mononuclear cells (PBMC). The purpose of the present study was to determine whether there is a correlation between Fc gamma R levels on PBMC and survival in patients with metastatic breast cancer. Binding assays were performed on PBMC using 125I-labeled fibrinogen complexed with rabbit IgG (or as a control F(ab')2) anti-human fibrinogen. Twenty-two metastatic breast cancer patients had significantly (p less than 0.001) elevated Fc gamma R levels as compared to either 22 breast cancer patients receiving adjuvant chemotherapy following mastectomy without clinical evidence of tumor, or to 34 non-malignant controls. Significantly more metastatic patients with elevated Fc gamma R levels died at 6 months (p less than 0.001) as compared to those with low levels. A direct correlation between Fc gamma R levels and hazard probability was found (correlation coefficient = 0.3321, p less than 0.005). These results raise the possibility that Fc gamma R levels on PBMC from metastatic breast cancer patients may be clinically useful as a prognostic marker of disease activity.

Adult↗
PubMed1986

Complete atrioventricular block after sublingual isosorbide dinitrate.

A 71-year-old woman, admitted for chest pain, received a 5 mg dose of isosorbide dinitrate sublingually. Within 2 min she became pale and diaphoretic and soon after lost consciousness. A monitor electrocardiographic lead showed sinus bradycardia followed by ventricular asystole. Sinus rhythm was restored by a precordial thump and intravenous administration of atropine. Our patient was receiving lidocaine intravenously because of ventricular premature beats. Its interaction with isosorbide is suspected of having caused the asystole.

Aged↗
PubMed1986

The effect of age on the prevalence of asymptomatic microscopic hematuria.

The medical files of a sample of men who had been followed by annual examinations from 1968 through 1978 were selected, using a random number sequence from the records of the Israel Air Force. One group of 430 men, ages 21-23 at entry, and a second group of 264 men, ages 25-28 at entry, were studied. The results of the urinalysis at entry and after ten years of follow-up were recorded. The point prevalence of all degrees of microhematuria increased significantly with age in both groups. One to three or more red blood cells (RBCs) per high-power field (HPF) were found in 3.5% of the subjects ages 21-23 at entry and in 14.2% in the same subjects ten years later (P = 0.001). Similarly, one to three or more RBCs per HPF were found in 4.9% of men ages 25-28 at entry and in 11.7% of the same subjects ten years later (P = 0.001). The authors conclude that age needs to be taken into consideration in drawing the line between physiologic and pathologic microhematuria.

Adult↗
PubMed1986

Primary liposarcoma of the heart.

A rare form of primary heart tumour, a liposarcoma, is reported. A discussion of diagnosis and modalities of treatment of primary heart sarcomas is presented.

Female↗
PubMed1986

Spontaneous pneumothorax and mitral valve prolapse.

We searched for mitral valve prolapse in patients with spontaneous pneumothorax to test the hypothesis that both may be part of a common disorder of connective tissue. Echocardiographic mitral valve prolapse was found in 11 (50 percent) of 22 patients who had suffered spontaneous pneumothorax compared to four (10 percent) of 40 age-matched control subjects (p less than 0.01). The body mass index (BMI) (weight/height2) was lower (p less than 0.001) in the group with pneumothorax; in five patients who were the thinnest in the study (BMI less than 2 standard deviations lower than mean normal value), mitral valve prolapse was present in four. The finding of a strong association of spontaneous pneumothorax with mitral valve prolapse, especially in subjects with an abnormal body build, suggests that in many patients, spontaneous pneumothorax may be a manifestation of a systemic abnormality of connective tissue.

Adult↗
PubMed1986

Low back pain in pilots.

A questionnaire on low back pain (LBP) was administered to 373 fighter pilots, 165 transport pilots, and 264 helicopter pilots. Helicopter pilots had more pain during flight than did fighter or transport pilots (34.5%, 12.9%, and 5.1%, respectively). A history of LBP temporally unassociated with flight was found in 26.5% of helicopter pilots, 31.5% of transport pilots and 25.2% of fighter pilots. We conclude that, despite the pain experienced by helicopter pilots in flight, they are not at increased risk for LBP unassociated with flight.

Adult↗
PubMed1986

Prevalence of postural T wave changes in mitral valve prolapse: a quantitative study.

The abnormal ECG T wave changes associated with mitral valve prolapse (MVP) were studied and quantitated in a group of 36 asymptomatic individuals with MVP and compared with a 27-member control group. The mean frontal plane T wave axis shifted markedly leftward on standing, with T wave axis less than or equal to 0 degrees in 16 (44%) of the subjects with MVP vs. only 2 (7.4%) of the control group, while the QRS-T angle widened to more than 60 degrees in 18 (50%) of those with MVP. Marked left axis deviation of the T wave on standing with T wave axis less than or equal to -30 degrees was found only in subjects with MVP, and their QTc interval was longer, P less than 0.05. In 11 subjects with mitral valve bowing or rounding on the echocardiogram (i.e., less than 2 mm posterior mitral valve displacement), intermediate grades of T wave axis shifts were seen.

Adolescent↗
PubMed1986

Systolic blood pressure in fighter pilots after 12-15 years service.

Systolic blood pressure (SBP) was measured at entry and after 12-15 years in 112 fighter pilots and compared to 112 transport and helicopter pilots. The pilots were 20-24 years old on entry into the study. Mean SBP +/- 1 S.D. on entry was 122 +/- 12 mm Hg in fighter pilots and 124 +/- 12 mm Hg in transport and helicopter pilots. After 12-15 years follow-up the mean SBP was 118 +/- 12 mm Hg in both groups. We conclude that the stress of flying fighter aircraft for 12-15 years is not associated with an increased risk of hypertension.

Adult↗
PubMed1985

Combined administration of propranolol and quinidine in the conversion of paroxysmal atrial fibrillation.

Quinidine was combined with propranolol to restore sinus rhythm in cases of paroxysmal atrial fibrillation (PAF) in 42 patients. The treatment was started with propranolol and quinidine at a test oral dose of 10 mg and 0.2 g, respectively, thereafter a dose of 0.4 g of quinidine and 10 mg of propranolol every two hours was added. The procedure was stopped when sinus rhythm was achieved, or when the administered quinidine reached the total dose of 1.6 g. Sinus rhythm was restored in 37 patients. The side effects were gastrointestinal disorders in 16 patients, atypical ventricular tachycardia in one case, and embolism of the left femoral artery in another patient.

Adolescent↗
PubMed1985

Retention of semifloating electrode catheter.

A semifloating electrode was prophylactically inserted in an 84-year-old man because of the presence of bifascicular block and the suspicion of acute myocardial infarction. After 6 days it was decided to remove the electrode, but its extraction was not possible. This case demonstrates that retention of semifloating electrode, although a rare complication of temporary right ventricular pacing, is more than a theoretical hazard.

Aged↗