Search PubMed⌕ Search

Biomedical subjects

J Barre

Publications and source records attributed to J Barre.

84 records · Page 5Linked to original sources
PubMedDate not supplied

Bioequivalence study of two pharmaceutical forms of rifampicin capsules in man.

In this study the bioavailability of a new pharmaceutical form of rifampicin, Rifampicine Generic (300 mg capsules), was compared to a reference form Rimactan (300 mg capsules). Twelve healthy volunteers participated in a cross-over study. Each dosage form was administered, one after the other, to each subject in the morning after a fasted night period. Both forms were well tolerated and no side effects were observed in any of the subjects during the study. Blood samples were collected over 10 h. The rifampicin plasma concentrations were determined by an HPLC method. The pharmacokinetic parameters, Cmax, Tmax, AUC0-10h (mean +/- SD), were 6.06 +/- 2.95 micrograms/ml, 2.33 +/- 1.60 h, 25.57 +/- 12.6 micrograms.h.ml-1, respectively, for the new form and 6.55 +/- 2.47 micrograms/ml, 2.04 +/- 1.37 h, 26.11 +/- 9.10 micrograms.h.ml-1, respectively, for the reference form. The statistical analysis of different parameters with the Westlake method, ANOVA, and the Wilcoxon test with a probability of 95% showed no differences between the two forms of rifampicin. It was concluded that Rifampicine Generic 300 mg capsules are bioequivalent to Rimactan 300 mg capsules.

Administration, Oral↗
PubMedDate not supplied

[Circulating forms of cyclosporin A].

The major circulating blood fraction of cyclosporin is localized in red blood cells. It is 58% for blood levels of less than 1,000 ng/ml. Beyond this concentration, a fall of this percentage is noticed which is related to a saturation phenomenon which occurs in its binding on an intracytosol protein, cyclophilin. Other fractions are distributed in the following manner: 27.5% on lipoproteins, 5% on albumin, 4% on polymorphonuclears, 5% on lymphocytes and 0.5% in the free state. There are various binding sites in the lymphocyte: in the membrane, cytosol on cyclophilin, and on the nucleus. The manner of binding on various plasma proteins, blood cells and platelets results in manifold pharmacological, pharmacokinetical, and toxicological results which are discussed here.

Blood Platelets↗
PubMedDate not supplied

[Abortion and the use of anaesthesia. Observations after two years' experience (author's transl)].

The authors give an account of their experience of anaesthesia in 380 abortion cases. Two kinds of technique were used: --paracervical block: 10.2 p. cent of the cases, only one complication; --narco-analgesia: considered to be essential. Dextromoramide was the principal analgesic used, chosen for its pharmacodynamic properties. Three narcotic drugs used successively in conjunction with this were: propanidine, with this drug per-anaesthetic complications and post-operative vomiting proved excessive, C.T. 1341 considerably reduced the frequency of these complications, disodic penthiobarbital did not give rise to any problems.

Abortion, Therapeutic↗