Biomedical subjects

J Barbosa Filho

Publications and source records attributed to J Barbosa Filho.

At least 19 recordsLinked to original sources

PubMed1992

[Amiodarone in heart insufficiency].

The purpose of this study was to analyse the effects of amiodarone on the treatment of cardiac failure. The effects of 200 mg/day of amiodarone were assessed in 18 patients with a history of cardiac failure. Functional class, heart rate, blood pressure, left ventricular ejection fraction, heart size, treadmill exercise tolerance and electrocardiogram were assessed before and eight weeks after the use of amiodarone, and the side effects were monitored. In 18 patients receiving amiodarone, the functional class and heart rate decreased significantly (p < 0.05) from 2.7 +/- 0.4 to 1.2 +/- 0.4 and 103 +/- 15 to 69 +/- 8.5 beats/min respectively. The ejection fraction and the exercise tolerance increased significantly (p < 0.05) from 29.2 +/- 5.5% to 41.5% and from 379.8 +/- 271 sec to 897.8 +/- 350.8 sec respectively. The incidence of atrial and ventricular arrhythmias decreased significantly and no side effects were observed. Amiodarone appears to produce benefits in patients with cardiac failure with atrial and ventricular arrhythmias.

Amiodarone↗

PubMed1991

[Medium- and long-term results of valvular prostheses].

Two hundred and thirty-nine patients undergoing cardiac valve replacement were analyzed from follow-up point of view. One hundred and twenty eight (53.6%) were female and 169 (70.7%) were of the white race. Twenty one (8.8%) were less than or equal to 20 years, 94 (39.2%) were greater than 20 and less than 40 years, 107 (44.7) were greater than or equal to 40 and less than 60 and 17 (7.3) greater than or equal to 60 years old. In 118 surgeries (45.3%) the heart valve was replaced by bioprosthesis and in 142 (54.7%) by mechanical prosthesis. In the bioprosthesis group the mitral valve was replaced 109 times (92.3%), aortic 6 (5%) and tricuspid 3 (2.5%). In the mechanical group the aortic valve was replaced 98 times (69%) and the mitral valve 44(31%). The patients had a follow-up period that ranged from 3 months to 18 years with mean 5 years. Before the surgery 15 patients (6.3%) were in functional class I, 38 (15.9%) in class II, 135 (56.5%) in class II and 51 (21.3%) in class IV. During the follow-up period we observed that 190 patients (79.5%) were in functional class I, 36 (15%) in class II, 11 (4.3%) in class III and only 2 (8%) in class IV. From the radiological point of view we observed that, during the period of observation, 62 (32.4%) normalized the heart size. During the follow-up period we observed that 20 patients (8.4%) presented prosthesis related complications, 15 (75%) with bioprosthesis and 5 (25%) with mechanical prosthesis. Eleven (55%) enduented reoperation without mortality.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1989

[Surgical treatment of high-risk valvar endocarditis].

The authors have studied the immediate and long term outcome of surgical treatment of acute phase infective endocarditis in a group of 33 high risk patients with valvular heart disease. The age varied from 2 to 68 years, 18 patients were male and 22 were of the white race. The aortic valve was the most frequently involved (18/54.5%), followed by mitral valve (13/39.3%), and tricuspid valve (2/6.0%). Twenty-four patients (72.7%) were in functional class III and seven (21.0%) in functional class IV. The noninvasive studies in those patients revealed 13 cases (39.4%) with normal cardiac size. The EKG was abnormal in 27 cases (81.8%) mostly with left atrial and ventricular hypertrophy. The echocardiogram revealed the presence of vegetations in 27 patients (81.8%) and the blood cultures were positive in 24 cases (72.7%). All patients were treated with antibiotics. The pathologic analysis revealed the presence of vegetations in 94% and structural alterations in 16.5%. Twenty-one patients had heart valve replacement with mechanical prosthesis (63.6%), 11 (33.3%) had bioprosthesis and one had tricuspid excision without replacement (3.0%). The hospital mortality was 12% and the late mortality 3%. Three deaths occurred in patients who had prolonged clinical treatment (more than 35 days) and one patient died of severe fungal endocarditis. The follow-up of the remaining 26 patients varied from 1 to 596 weeks (mean 183) demonstrating important clinical improvement and a normally functioning valve prosthesis. All patients remained in functional class I or II. The analysis of our data indicates that surgical treatment is the best option for high risk endocarditis and should be undertaken earlier in all patients in this group.

Acute Disease↗

PubMed1989

[Electrocardiogram in dilated cardiomyopathy].

The authors describe the main electrocardiographic features in 90 cases of dilated cardiomyopathy. The patients were divided into tree groups: in group I were the patients with electrocardiographic signs of left ventricular hypertrophy, in group II the patients with complete left bundle branch block and in group III the cases with right bundle branch block, was held in the group I 64 patients (71%), in the group II 22 (24.6%) and in the group III four case (4.4%). Seventy two cases (80%) showed arrhythmias. Atrial fibrillation was observed in 20 patients (28%), supraventricular tachycardia in two (3%), atrioventricular block, of the 1st and 2nd degree, in eight (11%), ventricular arrhythmias in 63 (87.5%) and supraventricular arrhythmias in 42 (58%). In the 64 patients, with left ventricular hypertrophy, 60 (93.75%) showed very important S waves in, at least two right precordial leads. Fourty four patients (73.3%) had rS pattern in right precordial leads, from V1 to V4, with the R waves in V5 and V6 with normal, low and height amplitude. A first degree left bundle branch block was recorded in 16 cases (25%), a pathologic Q waves in 22 (37.5%), low voltage in limb leads in 24 (37.5%), left atrial enlargement in 36 (56%), right atrial enlargement in two (3%) and atrial fibrillation in 10 (16%). In the 22 patients from the group II six (27%) had left atrial enlargement, two (9%) had right atrial enlargement and six (27%) atrial fibrillation. In the four patients from group III two (50%) had an incomplete right bundle branch block, two (50%) the complete form and all had atrial fibrillation.

Adolescent↗

PubMed1989

[Surgical treatment of high-risk valvular endocarditis].

The authors have studied the short and long term results of surgical treatment of acute phase of infectious endocarditis in a group of 33 high risk patients with valvular heart disease. The age varied from 2 to 68 years; 18 patients were male and 22 were of the white race. The aortic valve was most frequently involved (18/54.5%), followed by the mitral valve (13/39.3%) and tricuspid valve (2/6.0%). Twenty four patients (72.7%) were in functional class III and seven (21%) in functional class IV. The noninvasive studies in those patients revealed 13 cases (39.4%) with normal cardiac size. The ECG was abnormal in 27 cases (81.8%) mostly with left atrial and ventricular hypertrophy. The echocardiogram revealed the presence of vegetations in 27 patients (81.8%) and blood cultures were positive in 22 cases (66.6%). All patients were treated with antibiotics. The pathologic analysis revealed the presence of vegetations in 94% and structural alterations in 16.5%. Twenty-one patients had heart valve replacement with mechanical prosthesis (63.6%), 11(33.3%) had bioprosthesis and one had tricuspid excision without replacement (3.0%). The hospital mortality was 12% and the late mortality 3%. Three deaths occurred in patients who had prolonged clinical treatment (more than 65 days) and one patient died of severe fungal endocarditis. The follow-up of the remaining 26 patients varied from 01 to 448 weeks (mean 183) demonstrating important clinical improvement and a normally functioning valve prostheses. All patients are in functional class I and II. The analysis of our data indicates that surgical treatments is the best option for high risk endocarditis and should be undertaken earlier in all patients in this risk group.

Adolescent↗

PubMed1987