[Prostaglandin content of the gastrointestinal mucosa after partial gastrectomy of peptic ulcer].
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Biomedical subjects
Publications and source records attributed to J Banai.
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The endogenous mucosal PG levels (PGE2, PGF2 alpha, PGI2, TXB2) of the gastric stump were investigated from biopsy materials, after partial gastrectomy made for ulcer disease. The mucosa of the stomach remnant were found to contain mainly PGE2 and PGI2. The PG contents of the mucosa of gastric stump were not influenced by the type of resection. Mucosal PG concentrations on the greater curvature were not dependent on the patients' age, the indication of the gastrectomy, the duration of postoperative interval, or the sex of the patient. There was no relation between the secretion capacity of the resected stomach and the mucosal PG contents of the greater curvature. After Billroth I and II gastrectomy procedures equivalently fair correlations have been established between the mucosal levels of PGE2 and PGF2 alpha, PGE2 and TXB2, PGF2 alpha and TXB2, PGI2 and TXB2 on the greater curvature, respectively. After both types of gastrectomy the mean PGI2 mucosal concentration of the greater curvature was significantly lower than those of the gastroenteroanastomosis and lesser curvature below the cardia, which in turn did not differ from each other. Biliary reflux does not cause characteristic alterations of the mucosal PG levels on the greater curvature. No definite relation between the histological findings of the mucosa and the PG concentrations was observed, which suggests a secondary role of the endogenous PGs in the pathogenesis of light microscopic mucosal alterations of the resected stomach.
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A new method for testing lactose intolerance was developed. The examination is performed by jejunoscopy using lactose dilution for provocation and sucrose for control. Macroscopic and microscopic changes in the jejunal mucosa are examined after administration of solutions. The results of this study demonstrated that lactose administration causes prompt change in the jejunal mucosa in cases of lactose intolerance but had no effect in cases of lactose tolerance. Administration of sucrose did not result in any change. This method is effective in proving lactose intolerance and may be useful to elucidate the pathogenesis of this disorder.
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We have developed a new and rapid semiquantitative method of demonstrating disaccharidase activities in biopsy specimens obtained endoscopically from the jejunum. Biopsy samples are placed in sucrose or lactose solutions. Sucrase and lactase activities are detected by testing glucose in the solutions using commercial urine glucose detection strips.
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Aortoenteric fistula is a complication of aortic reconstructive surgery. Here, the authors describe a case of a secondary aortoduodenal fistula causing haemorrhage. Diagnosis was made by upper gastrointestinal endoscopy.
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