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J Baillargeon

Publications and source records attributed to J Baillargeon.

18 recordsLinked to original sources
PubMed1992

A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme.

Case-control studies of pancreatic cancer were conducted in 5 populations with moderate to high rates and differing dietary practices, using a common protocol and questionnaire. Comprehensive diet histories were completed for a total of 802 cases and 1669 controls identified in Adelaide (Australia), Montreal and Toronto (Canada), Utrecht (The Netherlands) and Opole (Poland). Positive associations were observed with intake of carbohydrates and cholesterol, and inverse associations with dietary fiber and vitamin C. These relationships were generally consistent among the 5 studies, and showed statistically significant and generally monotonic dose-response relationships. The relative risks for highest vs. lowest quintile of intake were estimated for carbohydrates to be 2.57 (95% confidence interval 1.64-4.03), cholesterol 2.68 (1.72-4.17), dietary fiber 0.45 (0.30-0.63), and vitamin C 0.53 (0.38-0.76). The consistency, strength, and specificity of these associations provides evidence for the hypothesis that some or all of these dietary factors may alter the risk of pancreatic cancer.

Adult↗
PubMed1992

[Diabetes mellitus and pancreatic cancer: a case-control study in greater Montreal, Quebec, Canada].

In a population-based case-control study of dietary risk factors in French Canadians in Montreal, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. It was found that the frequency of diabetes was almost three times higher in cases of pancreatic cancer (16%) than in the controls (6%), with an Odds Ratio (OR) of 2.52 and a Confidence Interval (CI) of 1.04-6.11. Fifty per cent of the pancreatic cancer cases had this disease before the cancer was diagnosed, compared with 71% of the controls at the time of the study. Those aged 50 years and over accounted for 75% of the cases and 71% of the controls (diabetic subjects); 68% of the cases were treated with a combination of diet and oral hypoglycemic agents compared with 86% of the controls. Insulin was used by 32% of the cases and 14% of the controls. These results suggest that diabetes may play a major role in the etiopathogenesis of pancreatic cancer in this urban population. A lot of controversy remains about the precise role of diabetes, and further studies are needed for a better assessment and understanding of the mechanisms of this association.

Adult↗
PubMed1991

Tobacco, alcohol, and coffee and cancer of the pancreas. A population-based, case-control study in Quebec, Canada.

A population-based, case-control study of pancreatic cancer was carried out in greater Montreal between 1984 and 1988. A total of 179 cases and 239 population-based controls were interviewed. This study was part of the SEARCH program of the International Agency for Research on Cancer of the World Health Organization. A strong positive association was observed between total cigarette smoking and risk of pancreatic cancer (odds ratio [OR] = 3.76; 95% confidence interval [CI], 1.80 to 7.83). The OR for current smokers in the highest quintile of number of cigarettes was 5.15 compared with 3.99 for exsmokers. Those who consumed alcohol were in general at lower risk than nondrinkers. Coffee drinkers were collectively at lower risk than nondrinkers, particularly when coffee was consumed with meals, not on empty stomach.

Adult↗
PubMed1991

Nutritional factors and pancreatic cancer in the francophone community in Montréal, Canada.

In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, response status, lifetime cigarette consumption and energy intake, there appeared to be an association with total fat intake (odds ratio in highest quartile relative to lowest quartile 2.24 [95% Confidence Interval (0.74, 6.73)] and, particularly, saturated fat [OR = 4.32, 95% CI(1.39,13.7)]. Although dietary cholesterol intake appeared to increase risk and a number of many micro-nutrients were apparently associated with reductions of risk, none were statistically significant. The results are consistent with a role of nutritional factors in the etiology of pancreatic cancer. The magnitude of the risks involved emphasizes the necessity for larger studies of this topic.

Adult↗
PubMed1983

[Predictive value of preoperative acidity tests in ulcer recurrence after supraselective vagotomy].

The authors have analysed the predictive value of the basal and peak gastric acidity levels, measured preoperatively, in a series of 27 supraselective vagotomies. They recommend care in the choice of this operation for hypersecretors and they propose criteria for the preoperative selection of the candidates. They suggest determination of the preoperative basal gastric acidity level and a cimetidine suppression test to identify patients at high risk for recurrence of the ulcer.

Adult↗
PubMed1975

An unusual beta-cell adenoma.

An unusual case of insulinoma in a 51-year-old man demonstrates the difficulties in diagnosing and treating hypoglycemia. From the many laboratory tests and procedures performed, the only findings typical of insulinoma were inappropriate values of plasma immunoreactive insulin in relation to the corresponding values of blood glucose, and these were sporadic. A small beta-cell adenoma in the pancreatic head was the cause of the hypoglycemia.

Adenoma, Islet Cell↗
PubMed1966

[Birth control].

Explore the source record for details and available documents.

Family Planning Services↗
PubMed1965

Family planning.

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Family Planning Services↗
PubMedDate not supplied

Cancer of the pancreas in two brothers and one sister.

Over the past decades, pancreatic cancer has emerged as one of the most important malignancies in humans. This disease assumes a position of growing importance in view of its rising incidence and poor prognosis. Some familial pancreatic cancer has been reported with suggestions of hereditary, nutritional, home and familial environmental risk factors, and the possible role of genes in the development of this cancer among the members of one family. In an on-going case-control study of diet and cancer of the pancreas in Montreal, so far we were able to identify several familial cases of cancer of the pancreas. The most interesting case is the occurrence of this disease in two brothers and one sister all in their seventh decade of life. There was no history of pancreatitis among the cases or their relatives. Data from this study suggest that a familial predisposition to pancreatic cancer may occur in later decades of life. The role of genetic and environmental factors such as home remedies, familial food habits, etc., in the etiology of this cancer among these blood relatives, all in the same generation of one family, are unknown.

Adenocarcinoma↗
PubMedDate not supplied

Reported family aggregation of pancreatic cancer within a population-based case-control study in the Francophone community in Montreal, Canada.

As part of the SEARCH Collaborating Study Group of the International Agency for Research on Cancer (IARC), a population-based case-control study of cancer of the pancreas was conducted in Montreal, interviewing 179 patients and 179 controls matched for age, sex, and language (French) and selected by a modified random-digit dialing method. Results showed a positive and strong association between cigaret smoking and pancreatic cancer. Total fat, particularly saturated fat, and cholesterol consumption and excess energy derived from fat were associated with positive risk; dietary fiber intake, retinol equivalent, beta-carotene, vitamin C, and calcium showed inverse association with risk. History of such medical conditions as constipation, gallbladder problems, and diabetes was also found to be associated with risk. More important, 7.8% of the pancreatic cancer patients reported a positive family history of the same disease, as compared with 0.6% among controls, a 13-fold difference between cases and controls. Within the original case-control study a further study of patients with instances of familial pancreatic cancer was conducted, based on 14 cases and 56 matched controls. The results support the finding of the main study, and there were no apparent differences in environmental-risk-factor profile in familial and nonfamilial cases. This unusual aggregation of familial pancreatic cancer among French Canadians cannot be explained by environmental factors alone. Some familial predisposition (hereditary factors) may play an important role in the etiology of this cancer, at least in this study region. The findings suggest the potential importance of conducting genetic studies of pancreatic cancer.

Canada↗