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Biomedical subjects

J BRUNET

Publications and source records attributed to J BRUNET.

12 recordsLinked to original sources
PubMed1963

[Clinical experience with a test of pituitary reserve].

A test of pituitary reserve was used in the investigation of 14 children with retarded growth and 15 adults with endocrine disorders. Mepyrapone (Metopiron), 500 mg. every four hours, was administered orally for 48 hours. The pituitary response was determined by the amount of 17-hydroxycorticosteroid in a 24-hour urine sample (by a modification by Peterson of the Porter-Silber method). Pituitary reserve was decreased in four patients who were pituitary dwarfs, one who had retarded growth, two patients with Sheehan's syndrome, three with pituitary tumours, one who had panhypopituitarism without a tumour, and one case of limited adrenal reserve (confirmed by a negative response to ACTH stimulation). The pituitary reserve was normal in three patients with gonadal dysgenesis, three who exhibited retarded growth, one case of diabetes insipidus, one cretin, one patient treated by steroids, three with psychogenic amenorrhea, and five normal controls. It is concluded that this test of pituitary reserve is useful in the assessment of children with growth retardation and in establishing the diagnosis of pituitary insufficiency in adults.

17-Hydroxycorticosteroids↗
PubMed1963

Clinical use of the glucose disappearance rate.

An intravenous glucose tolerance test, coupled with a graphical or mathematical analysis, has been used in normal, diabetic, and glycosuric subjects, and patients suspected of having hypoglycemia. From the analysis, a single value, K, is derived which integrates the disappearance of the injected glucose. A significant difference was found between normals and known diabetics: this difference becomes even more distinct when the disappearance of the glucose load is measured as K1 or Increment Index, as opposed to decrease of the total blood glucose, K2 or Total Index. A 300-g. carbohydrate diet was shown to be important to the success of this test. More than 400 patients have been tested in the investigation of different disorders of glucose metabolism. Renal glycosuria was diagnosed in 35 patients. Rapid disappearance of the glucose load has been observed in 18 of 40 patients suspected of having hypoglycemia. Of 64 patients diagnosed in the hospital as previously unknown diabetics, 59 presented K1 values below the normal range.

Blood Glucose↗