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Biomedical subjects

J B Weaver

Publications and source records attributed to J B Weaver.

58 records · Page 4Linked to original sources

Two applications of wavelets and related techniques in medical imaging.

We present two applications of wavelet and related techniques to problems arising in medical imaging. Both make considerable use of the edge detection and classification properties of wavelet-type representations. First we describe simple and effective techniques for image denoising and contrast enhancement based on the multiscale edge representation of images. These techniques are sufficiently flexible to successfully address the varying requirements posed by several different medical imaging modalities in common use today. Experimental results are presented to illustrate the application of these techniques to various types of medical images. Next we describe adapted waveform encoding, a technique for magnetic resonance imaging. One advantage of this technique is that it can be used to efficiently encode edge features of the object being imaged. This has a particular diagnostic application in tracking heart wall thickness during the cardiac cycle, which we present along with some experimental results along this line. We also present an analysis of the signal-to-noise ratios of images formed with this technique, as this is a factor of paramount importance in MRI. The fact that wavelet schemes tend to concentrate energy near edge features makes the result rather different than that found in standard Fourier based approaches. We indicate an exciting potential application of our technique: reducing spectral leakage in phosphorus spectroscopy.

Algorithms↗

Intrahepatic cholestasis of pregnancy: prevalence and ethnic distribution.

We undertook a retrospective analysis of the prevalence of obstetric cholestasis in the population of the South Birmingham area in the various ethnic subgroups. A diagnosis of intrahepatic cholestasis of pregnancy was made on the basis of symptoms of generalised pruritus along with biochemical evidence of the condition, after ruling out other liver diseases. We found an overall prevalence of 0.7%, with an occurrence in the white population of 0.62%, compared to that in the Asians of Pakistani origin of 1.46%. In the Asians of Indian origin it was found to be 1.24%. The prevalence of obstetric cholestasis was significantly higher in the Pakistani and Indian subgroups compared to the whites.

Asia, Western↗

Attenuation coefficients of body tissues using principal-components analysis.

Principal-components analysis is used to obtain a set of parameters for dual-energy radiography that completely describes the attenuation coefficient of any tissue over a given energy range. These parameters are the weighted averages of the densities of the elements present in a substance. Principal-components (PC) parameters are calculated for several soft tissues from measured attenuation coefficients published by Phelps et al. The calculated PC parameters are compared to the more conventional dual-energy representations of the attenuation coefficient: (1) the electron density/effective atomic number (or Compton/photoelectric) representation and (2) the equivalent water/equivalent aluminum thickness representation. The principal-components parameters represent the attenuation coefficients more accurately, and are more stable than the currently used parameters. In addition, these new parameters are sensitive to differences in the chemical composition and density, whereas the previous representations are primarily sensitive to changes in the density. It is concluded that the principal-components method provides a more sensitive and accurate indicator of changes in tissue composition than previous characterizations of the linear attenuation coefficient. The principal-components method provides a means for improving the accuracy of the characterization of tissues in dual-energy computed tomographic imaging and in dual-energy digital radiography.

Body Composition↗