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Biomedical subjects

J B Taxy

Publications and source records attributed to J B Taxy.

67 records · Page 4Linked to original sources
PubMed1978

Vasitis nodosa. Two cases.

Two cases of vasitis nodosa, one typical example and one unusual case, are presented. The first case was a complication of a previous vasectomy, manifested as a painful nodule at the site of previous surgery, and was associated with sperm granulomas. In the second case, no antecedent vasectomy had been performed, the lesion was located deep in the scrotum, and inflammation was scant. The clinical diagnosis of adenomatoid tumor was also consistent with some aspects of the histopathologic picture. In such cases, the diagnosis of vasitis nodosa can be resolved by finding spermatozoa within the proliferating ductules and individual epithelial cells. Electron microscopy can also be useful in eliminating the possibility that the nature of the proliferating cells is mesothelial. However, the etiology of vasitis nodosa in the absence of previous local traumatic or inflammatory insults remains obscure.

Adult↗
PubMed1977

Olfactory neuroblastoma: an ultrastructural study.

The ultrastructural features of two olfactory neuroblastomas are reported. By means of light microscopy, one was well differentiated while the other was a poorly differentiated, small cell neoplasm. The latter case required ultrastructural examination to establish the diagnosis. Electron microscopy of human tumors for diagnostic purposes may be particularly helpful in deciphering small, round cell tumors. Catecholamines were not biochemically detected in a portion of recurrent tumor from Case 2. The significance of this is equivocal in view of the limited previous biochemical studies of this neoplasm. However, by both light and electron microscopy, the morphology of olfactory and sympathetic neuroblastomas are strikingly similar.

Adolescent↗
PubMed1977

Malignant fibrous histiocytoma. An electron microscopic study.

Sixteen cases of malignant fibrous histiocytoma are presented. Electron microscopy of 15 cases demonstrated fibroblast-like and mononuclear and multinucleated histiocyte-like cells. A small capillary was at the center of all storiform areas examined. Ultrastructural examination can be diagnostically useful within the context of a narrow differential diagnosis by conventional microscopy and the ability, by electron microscopy, to eliminate other mesenchymal cell types. In 13 cases, follow-up information was available from 18 months to 9 years following histological diagnosis. Five patients are alive and 8 patients have died, including two non-tumor related deaths. In 3 cases follow-up was less than 4 months. The biologic behavior of the tumor in this series was generally not related to histopathological parameters. The issue of histogenesis is largely unresolvable. Ultrastructural studies of various types of fibrous histiocytomas, suggesting cells of origin other than histiocytes, give credence to the concept that the histiocyte may represent a morphologic state of a given mesenchymal cell rather than a particular cell type.

Aged↗
PubMed1976

Adenocarcinoma of the pancreas in childhood. Report of a case and a review of the English language literature.

A case of adenocarcinoma of the head of the pancreas in a 13-year-old girl is reported. Some areas simulated an islet cell tumor by light microscopy, but contained numerous eosinophilic granules which were PAS-positive and diastase resistant. Ultrastructurally, the granules were large (960 mum-3000 mum in diameter) and electron-dense, resembling zymogen granules. These granules often showed focal to complete degeneration, occassionally being continuous with a myelin figure. The granules of true islet cell tumors are ultrastructurally distinctive and it is urged, therefore, that all pancreatic neoplasms in children be studied by histochemistry and electron microscopy. Carcinoma of the pancreas in childhood is a rare tumor, often with a rapid clinical course resulting in death. Morphologic separation of cases reported in the English language literature can be made on the basis of acinar differentiation. This feature has been suggested as a peculiarity of childhood pancreatic carcinoma. However, there is a suggestion that this phenomenon occurs in a small percentage of adult tumours as well. More extensive morphologic studies in adult pancreatic cancer may be warranted.

Adenocarcinoma↗
PubMed1976

Female adnexal tumor of probable Wolffian origin: evidence of a low grade malignancy.

A broad ligament tumor with the histologic features of a female adnexal tumor of probable Wolffian origin, as described by Kariminejad and Scully, is reported. Although previous cases were thought to be benign, in the present case, hepatic metastasis occurred 6 years after resection of the primary. Cytologic features by light microscopy were more anaplastic than in the original cases. Ultrastructural findings were not specific for any normal adult or fetal mesonephric tissue previously studied by electron microscopy.

Adenocarcinoma↗
PubMed1976

Glomerulocystic kidney. Report of a case.

We describe a rare type of congenital renal cystic disease involving the Bowman capsule and adjacent abnormal tubules. The patient had a moderate degree of proteinuria, but otherwise normal renal function. Two subcapsular hepatic cysts manifested the only other visceral involvement. This case is morphologically similar to one previously reported. A purely descriptive morphologic term is suggested for this distinctive lesion, viz, glomerulocystic kidney.

Autopsy↗
PubMed1975

Tubular carcinoma of the male breast: report of a case.

Tubular carcinoma of the male breast is a rare neoplasm which may have a biological behavior comparable to its counterpart in females. A case of male tubular carcinoma treated by radical mastectomy and postoperative irradiation is reported. There was a metastasis to one axillary lymph node at the time of diagnosis. No associated areas of intraductal or infiltrating scirrhous carcinoma were found. Microscopic gynecomastia was present. The patient is alive and well 8 years postoperatively.

Breast↗
PubMed1975

Metaplastic cartilage in nondysplastic kidneys.

Four hundred ninety-seven patients representing the 525 total or polar nephrectomies performed at the Children's Memorial Hospital from 1938 to 1973 (excluding 1947), were reviewed retrospectively to determine the incidence and characteristics of renal dysplasia. The 46 specimens with this histologic diagnosis all exhibited typical primitive ducts with 13 being also associated with cartilage formation. In five patients, kidney showed focal chondrous metaplasis of the interstitium in association with chronic inflammation but without primitive ducts. The findings strongly suggest that the renal interstitium occasionally may react to injury by chondrous metaplasia and that, in the absence of primitive, ducts, cartilage in the kidney is not pathognomonic of renal dysplasia.

Adolescent↗
PubMedDate not supplied

Epithelioid schwannoma: diagnosis by electron microscopy.

The clinical, gross, and light microscopic features of two epithelioid tumors were not typical of either benign or malignant schwannoma. Both tumors displayed long, enveloping cytoplasmic processes that were outlined by layers of discrete basal lamina. Long-spaced collagen was found in one case. These well-developed electron microscopic features are those that are commonly encountered in benign Schwann cell tumors. Although one patient died postoperatively, the other is alive and well 12 months after surgery. The extent to which ultrastructural data can have an impact on the evaluation of Schwann cell tumors is unknown but requires further study.

Aged↗
PubMedDate not supplied

Pleomorphic xanthoastrocytoma: report of a case with light and electron microscopy.

A case of pleomorphic xanthoastrocytoma is reported with light and electron microscopic findings. This unusual tumor arose in a 15-year-old male. The tumor consisted predominantly of nests of xanthomatous cells and plump spindle cells surrounded by a prominent reticulin network. There was considerable cellular pleomorphism with abundant bizarre giant cells and multinucleated cells. Occasional mitoses were present. Electron microscopy and immunoperoxidase localization of glial fibrillary acidic protein (GFAP) confirmed the glial nature of the tumor. Recognition of this tumor is important. Despite its "m alignant" appearance, the tumor characteristically has a relatively good prognosis and should not be confused with high-grade gliomas or meningeal sarcomas, which require aggressive therapy.

Adolescent↗
PubMedDate not supplied

Role of the autopsy in congenital cystic hygroma.

Sixteen cases of congenital cystic hygroma were identified through a retrospective review of surgical pathology and autopsy records. Tissue sections of the cystic hygromas were available in 10 cases and were examined histopathologically and for reactivity to factor VIII antiserum. Of 13 cases with ultrasound examinations, cystic hygroma was diagnosed prenatally in 9. In 11 cases with successful karyotyping, six were 45, X. Histopathologic observations of lymphatic vascular architecture were apparent in 10 cases, and immunoreactivity of the endothelium to factor VIII antiserum was preserved regardless of the degree of autolysis.

Adolescent↗