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Biomedical subjects

J B Sharma

Publications and source records attributed to J B Sharma.

At least 55 records · Page 3Linked to original sources

Olanzapine and pregnancy.

This report focuses on the case of a pregnant woman with a bad obstetric history who developed psychosis at the 23 rd week of gestation. She was treated with olanzapine from the 24th week until 10 days prior to delivery. No adverse events occurred during pregnancy or delivery. The Apgar score was 8/10 at one minute and 9/10 at 5 minutes.

Adult↗

Sacrococcygeal teratoma: a case report.

A 23-year old second gravida presented with 8 1/2 months of amenorrhoea. The fundal height corresponded with 36 weeks of pregnancy with a single live foetus. Ultrasonography revealed a live foetus and a cystic mass over lower sacral region. Emergency caesarean section was performed and the baby was delivered with intact sacrococcygeal teratoma. The histopathological examination confirmed the diagnosis of sacrococcygeal teratoma with mature neural elements. The baby had died on day 10 and the postpartum period of the mother was uneventful.

Adult↗

Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor.

OBJECTIVES: To compare the efficacy and safety of drotaverine hydrochloride and valethamate bromide in shortening the duration of labor. METHODS: In a randomized controlled trial of 150 nulliparous women in established labor with cervical dilation of 4 cm, 50 women were given drotaverine (group I), 50 women were given valethamate (group II) and another 50 women were not given any medication (group III). Duration of labor, mode of delivery, side effects, and neonatal outcome were measured in all cases. Appropriate non-parametric tests and chi(2) tests were used for assessment of statistical significance. RESULTS: In the three groups, 100%, 96% and 46% women delivered within 6 h, respectively. The injection-to-delivery interval was significantly reduced in the drotaverine group (193.96 min) in contrast to the valethamate group (220.68 min) and control group (412.84 min). The rate of cervical dilation was highest in the drotaverine group (2.04 cm/h) compared with the valethamate bromide group (1.86 cm/h) and control group (1.01 cm/h). There were no major maternal or fetal adverse effects in any group, but minor side effects were more common in the valethamate group. CONCLUSION: Both intramuscular drotaverine hydrochloride and valethamate bromide are effective in acceleration of labor; however, drotaverine accelerates labor more rapidly and is associated with less side effects.

Cervix Uteri↗

National audit on the practice and training in breech deliveries in the United Kingdom.

OBJECTIVE: To assess training in breech delivery in the United Kingdom at the level of registrar. METHOD: Three hundred and nineteen registrars in obstetrics and gynecology in the United Kingdom replied to a postal questionnaire. RESULTS: The various indications of cesarean section in breech presentation answered by respondents were: pre-term labor, pelvimetric measurement of inlet/outlet less than 11.5 cm, primigravida, no spontaneous labor, estimated fetal weight less than 2.5 kg or more than 3.5 kg, non-progression of labor in active phase, non-delivery after one hour of active pushing in second stage. A total of 190 respondents (60%) felt that they had been given sufficient training in vaginal breech delivery but only 125 respondents (39%) had the training in the United Kingdom. CONCLUSION: There is a high rate of cesarean section in breech presentation due to inadequate training of junior staff in vaginal breech delivery.

Breech Presentation↗

Blood splashes to the masks and goggles during caesarean section.

A prospective study was performed of 100 caesarean sections (31 elective, 69 emergency) to determine the incidence of blood splashes to the masks and goggles of surgeons, assistants and scrub nurses. The rate of blood splashes was 40% on surgeons' masks, 49.29% on surgeons' goggles, 31% on assistants' masks, 21.12% on assistants' goggles, 23.1% on scrub nurses' masks and 15.71% on scrub nurses' goggles. The use of masks and protective goggles is strongly recommended to avoid body fluid contamination and acquiring disease in obstetrics.

Blood↗

Potential relationship between dengue fever and neural tube defects in a northern district of India.

A sudden increase in number of births of newborns with neural tube defects (NTD) was observed from June, 1989 to September, 1989 in Medical College and Hospital, Rohtak and various other government and private hospitals of the district of Rohtak. Out of a total 4785 deliveries whose records were collected, there were 87 newborns with NTD with an incidence of 18.18/1000 births which was three times higher than the previous incidence of 6.8/1000 births in the preceding 4 years. There was an epidemic of dengue fever in this area from September, 1988 to December, 1988 affecting almost one member from each family. This coincided with the period of their first trimester. Of these, 18 patients suffered clinically from dengue fever, 21 patients had positive dengue fever history in their family members, 21 patients had positive history in their neighbors. The cluster of NTD appears to be due to dengue virus infection.

Adolescent↗