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Biomedical subjects

J B Priest

Publications and source records attributed to J B Priest.

9 recordsLinked to original sources
PubMed1986

Clear cell leiomyoma (leiomyoblastoma) of the uterus: ultrastructural observations.

The ultrastructure of a benign uterine epithelioid leiomyoma with prominent clear cells ("leiomyoblastoma") was studied to define the subcellular changes that yield the distinctive light microscopic pattern of this rare lesion. The main constituent of the cytoplasm was multiple cytolysosomes composed of vesicular, membranous material. Aggregates of glycogen also contributed to the clear appearance of the cytoplasm seen by light microscopy. In addition, the cells contained scattered aggregates of typical smooth muscle myofilaments with densities that certified that the lesion was a variant of a leiomyoma. The fine structural features of this lesion are distinctly different than those described in gastrointestinal leiomyoblastomas and indicate that the uterine clear cell leiomyoma is a unique lesion that should be separated from nonuterine leiomyoblastomas. Furthermore, the ultrastructural features of the uterine clear cell tumor suggest the lesion represents a leiomyoma that has undergone sublethal cell injury. The term "leiomyoblastoma" implies a primitive tumor and is inappropriate; "epithelioid leiomyoma, clear-cell type" is preferred.

Actin Cytoskeleton↗
PubMed1982

Exercise-induced changes in common laboratory tests.

Examination of 19 serum biochemical and hematologic parameters in a group of white male runners, ranging in age from 23 to 47 years, just prior to and immediately after a 13-mile "mini-marathon," demonstrated a significant increase, by paired Student t-test, in mean values of: K+, BUN, creatinine, CK, LDH, AST (SGOT), alkaline phosphatase, bilirubin, uric acid and leukocyte counts. Prevailing environmental conditions were such as to produce no significant hemoconcentration. Using this group's statistics and this hospital laboratory's upper limits of normal, the percentage of values above two SDs are, for the resting state: K+ 7%, BUN 7%, creatinine 0%, CK 21%, LDH 21%, AST 0%, alkaline phosphatase 0%, bilirubin 7%, uric acid 7%, and leukocyte count 0%. Post-exertional values above normal limits are: K+ 7%, BUN 21%, creatinine 21%, CK 93%, LDH 86%, AST 0%, alkaline phosphatase 0%, bilirubin 14%, uric acid 36%, and leukocyte 71%. Consequently, abnormally high values for K+, BUN, creatinine, CK, LDH, bilirubin, uric acid, and leukocyte counts can often be expected in some patients who exercise heavily. The degree of the abnormality will depend on the level and length of exercise as well as the elapsed time between exercise and testing.

Adult↗
PubMed1981

Glycogen-rich clear cell carcinoma of the breast: a light and electron microscopic study.

A glycogen-rich clear cell carcinoma arose in the breast of a 49-year-old woman. Light microscopic examination of the neoplasm revealed both intraductal papillary growth and stromal invasion. Electron microscopic examination demonstrated neoplastic cells that contained massive quantities of nonmembrane-bound particulate glycogen and that formed numerous acini. Apically, these cells formed microvilli; laterally they formed tight junctions and desmosomes. Morphologic features of this neoplasm are similar to those of the fetal breast and to some other clear cell carcinomas arising elsewhere in the body.

Adenocarcinoma, Papillary↗
PubMed1981

Ultrastructure of Buschke-Loewenstein tumor.

A 44-year-old man suffered a Buschke-Loewenstein tumor that was treated by distal penectomy. Ultrastructurally, this tumor showed widened intercellular spaces, prominent microvilli, decreased numbers of and incompletely developed desmosomes, decreased tonofilaments, cytoplasmic dense bodies, enlarged nucleoli and annular nuclear bodies. These ultrastructural features are quite similar to those of squamous carcinoma but are dissimilar to those of condyloma acuminatum and, to a lesser extent, verrucous carcinoma. These data suggest that electron microscopy may be useful in differentiating the neoplastic Buschke-Loewenstein tumor from large condyloma acuminatum.

Adult↗
PubMed1979

Basal cell carcinoma--signet ring type. Ultrastructural study.

Light microscopic examination of a basalioma (basal cell carcinoma) revealed unusual keratinizing cells resembling signet ring cells with pink cytoplasmic inclusions. Ultrastructurally the inclusions consisted of filamentous masses encircled by abundant tonofilaments giving a striking picture of abnormal individual tumor cell keratinization.

Aged↗