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Biomedical subjects

J B Mehta

Publications and source records attributed to J B Mehta.

At least 55 records · Page 3Linked to original sources
PubMed1990

Acquired haemophilia.

Two cases of acquired haemophilia A are described. Neither had history of excessive bleeding in the past following operative procedures and both presented with spontaneous bruising as a result of F. VIII:C deficiency due to production of anti-F. VIII:C antibodies. The antibody titre of one case remained unchanged after 4 weeks of therapy with prednisolone and cyclophosphamide. No attempt was made to treat the second case as the antibody titre was very high.

Aged↗
PubMed1989

Effect of iron deficiency on renal function.

Renal function was assessed by determining three hour creatinine clearance (THCC) values in 20 patients (13 males, seven females; age 16-55 years) of nutritional iron deficiency anaemia. Mean transferrin saturation was 4.6% (SD 2.3). Haemoglobin and THCC were determined twice at the interval of three days before therapy. All patients received total dose iron-dextran intravenously. Three days after therapy, haemoglobin and THCC were determined again. Paired 't' test was used to determine the significance of the difference. There was no significant difference between the two pretherapy mean haemoglobin values (6.1 +/- 3.5 g/dl and 5.6 +/- 4.5 g/dl; p greater than 0.2), and the two pretherapy mean THCC values (67.2 +/- 36.9 ml/min and 70.3 +/- 22.8 ml/min; p greater than 0.5). There was no significant difference (p greater than 0.5) between pre-and post-therapy mean haemoglobin levels (6.6 +/- 2.2 g/dl). The difference between the pre-therapy and post-therapy THCC (95.3 +/- 34.0 ml/min) was statistically significant (p less than 0.01). It is concluded on the basis of these results that renal function as measured by THCC is impaired in iron deficiency anaemia, and it improves significantly within three days of total dose intravenous iron-dextran therapy when there is no significant increase in haemoglobin value. This is likely to represent the effect of iron at the tissue level independent of the anaemia.

Adolescent↗
PubMed1989

Iron loading anaemias.

Iron loading anaemias are characterized by anaemia, high serum iron, transferrin saturation and ferritin values, and haemosiderin deposits in parenchymal cells and reticuloendothelial tissue with or without organ dysfunction. Sideroblastic anaemias and congenital dyserythropoietic anaemias (CDA) are important types of iron loading anaemias. Two cases of sideroblastic anaemia and five cases of CDA type I are presented as prototypes of iron loading anaemias. Increased gastrointestinal absorption of iron remains the main mechanism of iron loading in these anaemias. Phlebotomy can be used to reduce the iron load in those with mild or moderate anaemia, whereas desferrioxamine can be used to chelate excessive iron in all cases irrespective of severity of anaemia.

Adolescent↗
PubMed1988

Isoniazid preventive therapy for tuberculosis. Are we losing our enthusiasm?

Contact investigation activities of the Tennessee Department of Health and Environment (TDHE) Tuberculosis (TB) Control Program from 1979 to 1985 were reviewed. Out of 32,722 identified contacts, 6,030 (20.1 percent) were infected (positive purified protein derivative [PPD]). Only 2,731 (45 percent) of the infected contacts were started on preventive therapy. Both the absolute number and the relative percentage of infected contacts starting on INH prevention therapy have gradually declined over the years. While 569 (67 percent) of the infected contacts were started on preventive treatment in 1979, only 296 (37.5 percent) received isoniazid (INH) preventive therapy in 1985. Although an increasing percentage of those starting preventive therapy completed the prescribed course, the enthusiasm for recommending preventive therapy has declined for the infected individuals above the age of 15. More enthusiasm and efforts are needed from physicians in initiating and maintaining INH preventive therapy to accomplish tuberculosis eradication.

Adolescent↗
PubMed1987

Bronchiolitis obliterans and Nocardia asteroides infection of the lung.

This report describes a patient with right lower lung (RLL) pneumonia of a subacute nature. Sputum and bronchial washings both grew N asteroides. Open lung biopsy showed bronchiolitis obliterans. Both the clinical and radiologic picture dramatically improved during three weeks of treatment with trimethoprim and sulfamethoxazole (TMP - SMX), indicating the possibility that N asteroides infection contributed to bronchiolitis obliterans pneumonia in this patient.

Aged↗
PubMed1984

Pseudomembranous colitis due to oxacillin therapy.

We have reported a rare case of oxacillin-associated pseudomembranous colitis in which great difficulty was experienced in successfully isolating the organism in a routine hospital laboratory, resulting in delay in treatment. Toxin assay done at a reference laboratory finally allowed successful treatment. Toxin assay can be valuable in the diagnosis and management of this potentially serious illness.

Clostridium Infections↗