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Biomedical subjects

J B Madison

Publications and source records attributed to J B Madison.

40 records · Page 3Linked to original sources

An in vitro biomechanical study of a multiplanar circular external fixator applied to equine third metacarpal bones.

The biomechanical characteristics of a 4-ring circular multiplanar fixator applied to equine third metacarpal bones with a 5 mm mid-diaphyseal osteotomy gap were studied. Smooth Steinmann pins, either 1/8 inch, 3/16 inch, or 1/4 inch, were driven through pilot holes in the bone in a crossed configuration and full pin fashion and fastened to the fixator rings using cannulated fixation bolts. The third metacarpal bone fixator constructs were tested in three different modes (cranial-caudal four-point bending, axial compression, and torsion). Loads of 2,000 N were applied in bending and axial compression tests and a load of 50 N x m was applied during testing in torsion. Fixator stiffness was determined by the slope of the load displacement curves. Three constructs for each pin size were tested in each mode. Comparisons between axial stiffness, bending stiffness, and torsional stiffness for each of the three different pin sizes were made using one-way analysis of variance. There was no visually apparent deformation or permanent damage to the fixator frame, and no third metacarpal bone failure in any of the tests. Plastic deformation occurred in the 1/8 inch pins during bending, compression, and torsion testing. The 3/16 inch and 1/4 inch pins elastically deformed in all testing modes. Mean (+/-SE) axial compressive stiffness for the 1/8 inch, 3/16 inch, and 1/4 inch pin fixator constructs was: 182 +/- 16 N/mm, 397 +/- 21 N/mm, and 566 +/- 8.7 N/mm; bending stiffness was 106 +/- 3.3 N/mm, 410 +/- 21 N/mm, and 548 +/- 12 N/mm; and torsional stiffness was 6.15 +/- 0.82 N x m/degree, 7.14 +/- 0.0 N x m/degree, and 11.9 +/- 1.0 N x m/degree respectively. For statically applied loads our results would indicate that a 4-ring fixator using two 1/4 inch pins per ring may not be stiff enough for repair of an unstable third metacarpal bone fracture in a 450 kg horse.

Animals↗

Evaluation of a biofragmentable anastomosis ring for small intestinal anastomosis in ponies.

Six ponies divided into two groups of three were used in a double crossover study design. Group 1 ponies had a small intestinal resection and anastomosis performed using a biofragmentable anastomosis ring (BAR); group 2 ponies had a hand-sewn small intestinal resection and anastomosis using a Gambee suture pattern. Approximately 30 days later, all ponies had a second celiotomy and anastomosed segments were removed. Group 1 ponies had a hand-sewn anastomosis performed and group 2 had a BAR. The anastomotic sites were collected at necropsy approximately 30 days later. Anastomosed intestinal segments were evaluated with ultrasound to determine lumen diameter, area, circumference, and wall thickness. Gross descriptions of adhesions were recorded and sections of the anastomotic site were taken for histological evaluation. Time to perform the BAR anastomosis was significantly less (P = .0004) than for the hand-sewn Gambee anastomosis. Ponies with handsewn anastomoses had no signs of colic, whereas five of six ponies with BAR anastomoses had several episodes of abdominal discomfort, between day 16 to 18, corresponding to the time of BAR disintegration as determined by abdominal radiographs. Hand-sewn anastomoses had a tendency to have more adhesion formation than BAR anastomoses, but all anastomoses, except one BAR anastomosis, were graded as having a low obstructive potential. BAR anastomoses had a significantly larger mean index of stenosis for intraluminal diameter (76% +/- 13.6), area (93.7% +/- 6.01) and circumference (75.8% +/- 14.0) than the hand-sewn anastomoses (26.6% +/- 11.9; 44.6% +/- 19.5; 26.8% +/- 12.7). The BAR anastomoses also had a significantly smaller mean intraluminal diameter (0.96 cm +/- 0.49), area (0.838 cm2 +/- 0.65) and circumference (3.28 cm +/- 1.63) than the hand sewn anastomoses (3.11 cm +/- 0.73; 7.99 cm2 +/- 3.9; 10.3 cm +/- 2.47). In addition, the BAR anastomoses had a significantly larger (P = .0069) bowel wall thickness at the anastomoses and a significantly larger (P = .047) wall thickness proximal to the anastomosis than the hand-sewn anastomoses, indicating some degree of hypertrophy because of chronic obstruction. No significant difference was found in the diameter, area, or circumference between bowel proximal and distal to the anastomosis for either the BAR or Gambee techniques, or between the BAR and Gambee anastomosis as a measure of chronic obstruction. There was a significantly higher (P = .0043) histological score (worse healing) for mucosal healing and continuity for the BAR, as well as a tendency to score higher for inflammation, anastomotic alignment, and anastomotic fibrosis. The BAR technique had a significantly higher (P = .0043) total histological score than the Gambee technique. Although the BAR was advantageous in many respects, results of this study suggest that it should not be used for equine small intestinal anastomosis because of the potential for stricture formation.

Anastomosis, Roux-en-Y↗

Arthroscopic examination and treatment of osteochondritis dissecans of the femoral condyle of six dogs.

Arthroscopy was used to diagnose and treat osteochondritis dissecans (OCD) of the femoral condyle in six dogs. Bilateral lesions were seen in two dogs. The medial condyle was affected in five stifles, and the lateral condyle was affected in three stifles. Subchondral bone defects were identified on radiographs in six of eight affected stifles. Resolution of the lameness associated with the arthroscopic procedure occurred one-to-14 days (mean, three days) following arthroscopy. Lameness resolved completely in four cases within two weeks and in one case six weeks following arthroscopy. Mild lameness persisted in one case. Arthroscopy is an effective means of diagnosis and treatment of OCD of the femoral condyle, and it is associated with minimal postoperative morbidity when compared to arthrotomy.

Animals↗

Evaluation of four interfragmentary Kirschner wire configurations as a component of screw/wire/polymethylmethacrylate fixation for acetabular fractures in dogs.

The biomechanical contribution of the interfragmentary Kirschner wire as a component of composite fixation for acetabular fracture repair was subjectively and objectively evaluated. Acetabular osteotomies were repaired using the screw/wire/polymethylmethacrylate (SWP) composite fixation with or without one of three configurations of Kirschner wire in 32 hemipelves obtained from 16 dogs. Reduction, assessed objectively and subjectively, was unaffected by Kirschner wire placement. Hemipelves repaired with Kirschner wire(s) were subjectively more stable prior to application of polymethylmethacrylate when manually assessed in multiple planes. Consistent incremental increases in stiffness, yield load, and maximum load sustained that were observed during biomechanical testing were not significant, with the exception that hemipelves repaired with two Kirschner wires had significantly greater yield loads than hemipelves repaired without Kirschner wires. The subjective results of this study support the use of at least one interfragmentary Kirschner wire to maintain reduction prior to polymethylmethacrylate application; however, fracture configuration and location may dictate the number and pattern of interfragmentary Kirschner wires used to maintain reduction prior to application of the polymethylmethacrylate. The objective results and observations made during biomechanical testing suggest that use of one or more interfragmentary Kirschner wires may enhance stability after polymethylmethacrylate application.

Acetabulum↗