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Biomedical subjects

J B Kruger

Publications and source records attributed to J B Kruger.

6 recordsLinked to original sources
PubMed1986

Noise analysis of scintillation camera images: stochastic and non-stochastic effects.

An analysis of noise was performed on scintillation camera images. The analysis was performed on sets of field floods, uniform exposures over the field of view, in such a way that stochastic and non-stochastic effects were separable. Stochastic noise for the digitally acquired images was found to approach the limit of Poisson count statistics. The non-stochastic component of the calculations dominated the results at the lower spatial frequencies. These results hold true even after standard methods of uniformity correction are applied, primarily due to the effects of Compton scatter events. The noise power spectrum calculations carry information about the patterns of the noise in flood images. Examples of digitisation, photomultiplier tube mottle and edge-packing artefacts are presented.

Photography↗
PubMed1984

Effects of tendamistate (an alpha-amylase inactivator), guar and placebo on starch metabolism.

Nine volunteers participated in a double-blind, cross-over study to compare the effects of tendamistate (HOE 467), guar and placebo on starch metabolism. In each phase of the trial they received a maize-meal porridge breakfast. They either received 5 g guar granules before the porridge or 100 mg tendamistate mixed with the porridge, or porridge alone. Sequential plasma glucose concentrations served as a criterion of starch digestion. The area under the plasma glucose curve and maximal glucose concentrations after administration of tendamistate with the starch were significantly lower (P less than 0,05) than after guar and placebo. No significant differences were found between placebo and guar. We concluded that tendamistate effectively attenuates starch digestion and is superior to guar in reducing postprandial glycaemia.

Adult↗
PubMed1984

Pharmacodynamics and tolerability of low doses of tendamistate given with starch.

Six healthy male volunteers participated in a double-blind cross-over study in which 12,5 mg, 25 mg, or 50 mg tendamistate (HOE 467), an alpha-amylase inactivator, or placebo were administered with 100 g maize meal, which contains 85,5 g pure starch. Serial blood specimens for measurement of plasma glucose concentrations, which served as a criterion of starch absorption, were taken up to 3 hours after each starch meal, and side-effects were recorded. The administration of HOE 467 with a starch meal resulted in a significant inhibition of starch absorption. Side-effects were not severe. Flatulence occurred in the placebo phase as well as after administration of the active drug. Loose stools were reported by 1 subject after 25 mg tendamistate.

Blood Glucose↗
PubMed1981

Film reciprocity law failure in scintillation camera imaging.

Sensitometric measurements of scintillation camera images show that substantial changes in film response occur with variations in imaging time or dot focus. Both the speed and the slope of the film characteristic curve are affected. The phenomenon responsible for the variation in response is referred to as "film reciprocity law failure" and is inherent in the image-forming process.

Photography↗