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Biomedical subjects

J B Foster

Publications and source records attributed to J B Foster.

44 records · Page 3Linked to original sources

Double-blind controlled trial of a micronized preparation of flumedroxone (Demigran) in prophylaxis of migraine.

A double-blind cross-over trial of a micronized preparation of flumedroxone, an oral progestogen derivative, and a placebo was undertaken to determine whether this drug had prophylactic value in migraine. No benefit was found in males, or in females with no history of menstrual exacerbation of migraine. In women whose migraine was worse around the time of menstruation flumedroxone resulted in statistically fewer headaches of less severity.With the dose used in this trial (micronized flumedroxone 10 mg. t.d.s.) side-effects were frequent, the commonest being polymenorrhagia, which occurred in half the women of reproductive age.

Clinical Trials as Topic↗

Hydromyelia.

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Arnold-Chiari Malformation↗

Malignant cerebrovascular thromboembolization by phaechromocytoma.

We describe an unusual case of malignant thromboembolization within the aortic arch of a 56-year-old man who presented with a stroke. The uncommon source of this malignant embolus was an adrenal phaeochromocytoma which had permeated the inferior vena cava, metastasized into the pleural cavity and colonized the intimal surfaces of the aortic arch and carotid vessels. The relevant literature has been briefly reviewed.

Adrenal Gland Neoplasms↗