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Biomedical subjects

J Axelrod

Publications and source records attributed to J Axelrod.

At least 325 records · Page 18Linked to original sources
PubMed1967

Visual pathway mediating pineal response to environmental light.

Activity of the melatoninforming enzyme, hydroxyindole-O-methyltransferase, in rat pineal is increased when the animal is exposed to continuous darkness, and it is decreased by exposure to continuous light. Response to environmental light is initiated in the retina and transmitted to the pineal by way of the central nervous system and the cervical sympathetics. The central visual pathway essential for mediation of this response is the inferior accessory optic tract. Visual pathways to thalamus and tectum do not participate in this response.

Animals↗
PubMed1966

Light-induced changes in pineal hydroxyindole-O-methyltransferase: abolition by lateral hypothalamic lesions.

The activity of hydroxyindole-O-methyltransferase, the melatoninforming enzyme in the pineal gland, is several times greater in rats kept in continuous darkness than in those kept in continuous light. Lesions transecting the medial forebrain bundle in the lateral hypothalamus suppress these differences in enzyme activity and abolish light-induced changes in pineal weight. These findings indicate that the medial forebrain bundle may participate in the control of this enzymatic response to environmental lighting.

Animals↗