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Biomedical subjects

J Avery

Publications and source records attributed to J Avery.

31 records · Page 2Linked to original sources
PubMed1980

A comparative trial of intra-nasal beclomethasone dipropionate and sodium cromoglycate in patients with chronic perennial rhinitis.

A double-blind crossover study has compared intra-nasal sodium cromoglycate (SCG) with beclomethasone dipropionate (BDP), and both drugs with placebo, in fifty-two chronic perennial rhinitis patients. BDP was significantly more effective in relieving symptoms than SCG (76.9% and 50% of the patients improved respectively, P < 0.01). Both drugs were more active than placebos but while BDP was very clearly more effective (P < 0.0005) SCG was only marginally better than its placebo (P < 0.05, Fisher; P = 0.068, chi 2). BDP was selected by 56% of the patients as the best agent for continuing therapy at the end of the trial. By contrast SCG was preferred by the same number of patients as chose the two placebos (11.5%).

Administration, Intranasal↗
PubMed1978

Effects of craniofacial structures on mouse palatal closure in vitro.

Heads of Swiss-Webster mouse fetuses of four ages spanning days 12-13 of gestation, were partially dissected by removing the brain (B), tongue (T) and mandible (M) alone or in combination (BT, BM, BTM). Preparations were suspended in a gassed, circulating culture system such that palatal closure must take place against gravity. Closure occurred earlier than in vivo and required the posterior half of the mandible be intact and the tongue removed.

Animals↗
PubMed1976

Automated enzymic determination of ethanol in blood, serum, and urine with a miniature centrifugal analyzer.

We describe an automated spectrophotometric reaction-rate method for determination of ethanol in serum and urine with a miniature centrifugal analyzer. The theanol is selectively oxidized in the presence of alcochol dehydrogenase and NAD+ to form NADH, which is measured by the rate of change of its absorbance. Reaction rates are determined automatically, and unknown concentrations are calculated from a computer-generated working curve based on aqueous ethanol standards. Blood, serum, or urine specimens need not be deproteinized. The method permits duplicate analysis of at least 30 samples per hour. Coefficients of variation and relative errors are about 2-3% for ethanol concentrations of 0.3-3.0 mug per 2 mul of sample. Analytical recovery of ethanol added to serum is 92-103% (average, 98.5%). Comparisons with distillation-oxidation, gas-chromatographic, and conventional enzymic procedures give satisfactory agreement.

Alcohol Oxidoreductases↗
PubMed1975

A new in vitro system for studying secondary palate development.

An in vitro system was devised which supports palate development in partially dissected embryonic mouse heads. The heads were suspended in the culture chamber so that they were not held in a fixed orientation and were constantly surrounded with a fluid medium. Under these circumstances the developing palate must effect closure without the aid of gravitational forces. The culture medium was constantly circulated, gassed with 95% O2, 5% CO2 using hollow fiber gas permeation devices, and kept at 34 degrees C. Swiss-Webster mouse embryos of 12 days 12-18 h (ca. 48 h prior to expected in vivo closure) or 13 days 8-14 h (ca. 24 h prior to closure) were used to test the ability of the system to support palatal development. Embryonic heads were dissected in one of two ways before culture: brain and tongue removed, or brain, tongue and mandible removed. After 24 h in culture, preparations of either age with only the brain and tongue removed had made substantially greater progress than their counterparts with the brain, tongue and mandible removed. With only the brain and tongue removed, the palatal shelves were contacting, adhered or fused in 67% of the older embryos of the same age cultured with the brain, tongue and mandible removed had shelves that were not fully elevated and still separated by a moderate gap. Thus for maximal progress in the present system, the oral cavity must be intact except for the tongue.

Animals↗