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Biomedical subjects

J Austad

Publications and source records attributed to J Austad.

33 records · Page 2Linked to original sources
PubMed1991

Hereditary hemorrhagic teleangiectasia--argon laser.

In 20 patients with hemorrhagic hereditary teleangiectasias (HHT) only 15 were treatable with argon laser. In the others septal perforation or continued bleeding made initial treatment inadequate. The laser treatment had to be repeated in all patients, due to multiplicity of lesions. Nine patients regarded the outcome very favourably with minimal bleeding episodes. In four of them the effect lasted more than one year.

Adult↗
PubMed1985

Effect of UVB on alloactivating and antigen-presenting capacity of human epidermal Langerhans cells.

Human epidermal cell suspensions (EC) were obtained by the suction blister technique and enzyme digestion. EC were irradiated in microtitre plates with doses up to 510 mJ/cm2 (2.6 minimal erythemal dose (MED] by means of fluorescent light bulbs emitting a 280-320 nm continuous spectrum with a peak at 310 nm. Purified allogeneic T cells were added to the EC immediately or 24 h after radiation. Irradiated EC were pulsed with purified protein derivative (PPD) for 90 min immediately or 24 h after radiation and then cocultured with purified autologous T cells. PPD-pulsed EC were also irradiated before being cocultured with autologous T cells. Pretreatment of EC suspensions with anti-DR antiserum plus complement abolished both the alloactivating and the antigen-presenting capacity, indicating that the DR-positive Langerhans cells are mainly responsible for these functions. There were no differences in the number of DR-positive cells in EC before or immediately after radiation. A statistically significant and UV-dose-dependent reduction of the alloactivating ability of EC was found both when allogeneic T cells were added immediately and when they were added 24 h after radiation. Likewise, a significant and dose-dependent reduction of the PPD-specific T-cell response was obtained in cultures when using irradiated EC that were PPD-pulsed immediately or 24 h after radiation. EC that were first PPD-pulsed and then irradiated induced a significantly increased T-cell response after low UV doses (1 or 2 MED), whereas higher doses induced a significant reduction of the T-cell responses.

Antigen-Presenting Cells↗
PubMed1983

Effects of short-wave ultraviolet radiation (UV-C) on delayed hypersensitivity in the guinea-pig.

Guinea-pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UV-C radiation (254 nm) on one of the flanks for a period of 15 days. They were then patch-tested with DNCB immediately after UV treatment. The responses to DNCB were diminished both in the irradiated and non-irradiated skin compared with control animals which had not received UV-C radiation. This effect was dose dependent and could only be demonstrated for a limited period of time. Guinea-pig exposed to UV-C radiation did not show a decreased response to sodium lauryl sulphate, which is a potent irritant. The influence of UV-C on delayed hypersensitivity therefore seems to be an immunological effect.

Animals↗
PubMed1983

Phototoxic dermatitis caused by celery infected by Sclerotinia sclerotiorum.

11 men developed a severe phototoxic dermatitis of the hands and forearms after harvesting celery infected with Sclerotinia sclerotiorum. By thin-layer chromatography and fluorescence spectrophotometry, xanthotoxin, bergapten and sphondin were isolated. The Canadida albicans test demonstrated xanthotoxin and bergapten as the phototoxic compounds.

Agricultural Workers' Diseases↗
PubMed1983

Short-wave ultraviolet light (UVB) treatment of allergic contact dermatitis of the hands.

7 out of 10 patients with long-standing allergic contact dermatitis of their hands were successfully treated with short-wave ultraviolet light (UVB) and the contact dermatitis healed completely. To maintain this result they had to receive UVB therapy regularly once a week. The last 3 patients also showed improvement, but they had periods with vesiculation during the treatment. UVB treatment seems to be a valuable supplement for the treatment of contact dermatitis.

Adult↗
PubMed1982

Effects of short-wave ultraviolet light (UVB) on delayed hypersensitivity in the guinea pig.

Guinea pigs, previously sensitized to dinitrochlorobenzene (DNCB), were exposed to varying doses of UVB radiation on the right flank for a period of 12 days. The response to an elicitation dose of DNCB was diminished in the irradiated skin immediately after UV treatment. This effect was dose-dependent. No reduction in the response could be demonstrated in unexposed skin. One week after UVB treatment the response to DNCB was increased, and after 2 weeks there was a normal eczematous reaction after application of DNCB.

Animals↗
PubMed1981

Effects of PUVA on delayed hypersensitivity in the guinea-pig.

Guinea-pigs previously sensitized to dinitrochlorobenzene (DNCB) were topically treated with 8-methoxypsoralen solution and longwave ultraviolet light (PUVA). The animals showed moderate or no clinical and microscopic responses to an elicitation dose of DNCB given immediately after the period of treatment. Exposure to ultraviolet light or psoralen alone did not affect the allergic response. Ten days after PUVA treatment there was a normal eczematous reaction after application of DNCB.

Animals↗