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Biomedical subjects

J Aubert

Publications and source records attributed to J Aubert.

At least 145 records · Page 8Linked to original sources
PubMed1982

[Toxic effects of nitrosamines with respect to marine organisms].

Nitrosamins present in the aquatic medium are considered as carcinogenic substances to the laboratory animals. This experimentation has for object to precise toxicity effects of the nitroso-compounds: nitrosodimethyllamine (NDMA) on two phytoplankton cultures, and on the common mussels. The addition of NDMA to the seawater of aquarium, in particular experimental conditions induces toxicity effects on the growth and behavior of phytoplanktonic cultures and of the common mussels: Mytilus edulis (tissus modification, and attack of some organs).

Animals↗
PubMed1982

[Alkaline-urine incrusted cystitis. Clinical aspects and treatment].

The authors report 2 cases of a condition often overlooked by the urologist: incrusted cystitis. It shows up clinically with severe urinary troubles and bladder calcifications. In fact the main finding is calcified plaques in the mucosa causing an inflammatory reaction and mimicking a tumor. Histologic examination of endoscopic biopsies rules out tumor and reveals a calcified necrotic mucosa. A high degree of alkalinity of the urine makes the diagnosis of incrusted cystitis after ruling out tuberculosis and bilharziasis. Acidifying the urine clears up the trouble and brings the bladder mucosa back to normal. According to the literature, 3 factors are necessary for the development of incrusted cystitis: a ureolytic microbe capable of releasing ammonia, alkalinity of the urine resulting from this, and a bladder with lesions of cystitis whatever might be the cause. A number of diagnostic errors are possible, but the most serious one is mistaking it for a calcified malignant tumor of the bladder. For this a biopsy is essential to prove the absence of a tumor. The treatment consists of 3 stages: excision of the calcified plaques (mostly by endoscopy), sterilization of the urine (nalidixic acid would be the best agent) and acidification of the urine.

Aged↗
PubMed1981

[Use of data processing cards for information retrieval from medical documents. Case reports, bibliographic references, series of observations (author's transl)].

The authors have given pride of place to an old system, punched cards selectors, which are fairly inexpensive to run, and are very flexible in their use. Each card has a part reserved for identification purposes (a case report number or a dated reference to an indexed list of articles) and another part for identification of a certain number of key-words with their corresponding numerical codings, which are also listed in a thesaurus. These key-words serve both for classifying case reports from each department, and for the bibliographic reference cards. When a series of cases are being studied. However, a new thesaurus has to be established during the course of the study. The 960 possible perforations on the international IBM card are largely sufficient as the number of key-words (case reports or bibliographic card-index codings) is not more than 700 and it is unusual to require more than 900 items during the course of a study. The authors find this system very satisfactory and no longer use large computers.

Dictionaries as Topic↗
PubMed1981

[A rare tumour: paravesical pelvic haemangiopericytoma (author's transl)].

Haemangiopericytomas are vascular tumours derived from Zimmerman's pericytes, the cells surrounding blood capillaries which correspond to the smooth muscle cells in the arterial and venous walls. This rarely observed tumour is usually found in the limbs (more than 50 p. cent of cases) or the face. Pelvic haemangiopericytomas are most frequently observed in women, and are then of uterine origin, their occurrence in men, and in the perivesical space, being exceptionally rare (seven cases reported in the publishing literature). The authors describe such a case, and review the clinical and radiological characteristics of the lesion. Diagnostic difficulties are emphasized, as confusion with a sarcoma can arise, even after histological examination. Surgical excision should be conducted routinely, but local recurrence or pulmonary metastases may occur in view of the potential malignancy of these tumours. Complementary cobalt therapy is therefore justified.

Diagnosis, Differential↗
PubMed1981

[Anatomical study of the twelfth intercostal nerve and oblique lumbotomies (author's transl)].

After a very precise anatomical review, the authors report the results of an anatomo-radiological study involving 244 urography films. The usual length of the 12th rib is 11 cm, with a width of 1 cm in the female and 1.5 cm in the male. The costo-lumbar angle was 45 degrees in 3/4 of the films. The kidney was often lower in the female than in the male. The renal artery was almost always given off at the level of the 12th rib or below, whilst at the level of the hilum, the renal artery and 12th rib having crossed, the artery was always above the 12th rib. Study of 173 usable cases of patients operated upon by lumbotomy revealed the following data: --lumbotomies on the 12th rib never opened the pleura, and gave rise to transient wall pain (7%) and one single case of abdominal wall hypotonia (1.4%) with no incisional hernias; --lumbotomies over the 11th rib were associated with 13% of cases of damage to the pleura, 16% of spontaneously resolving wall pain, 7 cases of prolonged parietal hypotonia and one incisional hernia out of 60 lumbotomies; --lumbotomies sub-jacent to the 12th rib were associated with residual abdominal wall pain in 3 cases out of 16. Lumbotomies over the 11th rib are associated with the risk of section of the superficial and deep abdominal branch of the 12th nerve and are hence those exposing to the greatest risk of abdominal wall hypotonia and neuralgia. Incision over the 12th rib would thus appear to be that associated with the least abdominal wall complications.

Female↗
PubMed1981

[Secondary amputation of the penis in the sequelae of local therapy with iridium 192 for carcinoma (author's transl)].

The author reports 4 cases of severe delayed irradiation complications which required partial or complete secondary amputation of the penis for sequelae of local therapy with Iridium. After reviewing the modes of spread of carcinoma of the penis and the various therapeutic possibilities in the light of these 4 cases, the author raises the question as to whether such conservative treatment by interstitial radiotherapy is well-founded. He would tend to suggest immediate surgery giving an identical result at the price of much shorter treatment and which would be free of the complications reported following radiotherapy.

Aged↗
PubMed1980

[Compensatory hypertrophy of the kidney. Experimental data and applications to man (author's transl)].

Compensatory hypertrophy of the kidney is a puzzling phenomenon of considerable importance, as it makes it possible for a patient with one kidney absent, destroyed or removed to lead a normal life. Non wonder then that since the beginning of the century it has given rise to numerous studies, first on animals, then on live renal transplant donors. The increase in volume of the remaining kidney is not due to an increase in the number of nephrons, but to hyperplasia and, mostly, hypertrophy of the cells of proximal convoluted tubules. Functional adaptation essentially results from increased tubular reabsorption but also involves all other kidney functions, so that the overall renal function of subjects with only one kidney is almost the same as that of subjects with two kidneys. The mechanism which triggers off compensatory hypertrophy remains unclear, and several theories still need to be confirmed.

Age Factors↗
PubMed1980

[Tetralogy of Fallot, congenital coronary aneurysms with the histology of periarteritis nodosa: nosologic problems].

Coronary lesions of periarteritis nodosa are detected in a newborn suffering from a Fallot's tetrad. The authors remind us of the present concept of infantile P.A.N. similar to adults' and of the notion of Kawasaki's syndrom that is almost the same as the infant's serious P.A.N. The reported case, original in many a detail, seems to represent the later expression monosymptomatic of Kawasaki's syndrom as if this one had been amputated at that stage of the greater part of its elements and then, casually developed in utero upon a congenital cardiopathy.

Aneurysm↗
PubMed1980

[Evidence for a glucose-dependent renal phosphorus leak in normo- and hypercalciuric stone-formers (author's transl)].

Changes in phosphatemia and in maximum renal threshold phosphate concentration (TmP/GFR) have been measured before and 45 and 75 min after oral ingestion of 75 g of glucose in 10 hypercalciuric lithiasic patients (HCI), 8 normocalciuric lithiasic patients (NCI) and 7 control subjects. After glucose ingestion, whereas plasma phosphorus decreased in all 3 groups, TmP/GFR decreased significantly in HCI and NCI but not in controls. A slight increase in calcium excretion was noted in the subjects with HCI and NCI after glucose load. Plasma concentration of 1,25(OH)2D was measured in 8 HCI and 7 controls before and after glucose: there was a significant increase in HCI 45 min after glucose and no modification in control subjects. These results show that a glucose load causes a decrease in TmP/GFR in lithiasic subjects. The results demonstrate the existence in lithiasic patients of perturbations of renal handling of phosphates which could, at least in part, be related to glucose metabolism. This trouble could contribute to the elevation of the serum 1,25(OH)2D observed in these patients.

Adult↗
PubMed1980

[Thoracic ectopic kidney (author's transl)].

On the basis of a case of thoracic ectopic kidney, discovered following trauma and diagnosed at laparotomy (since it was confused with rupture of the left diaphragm) the authors review certain data concerning this rare malformation (150 published cases). --The site of origin of the renal artery may be used to distinguish on the one hand between true intra renal ectopic kidney with the renal artery arising from the aorta and secondly trans-diaphragmatic herniation of a kidney with a kidney with a normal vascular pedicle through a hernia, most often congenital, and equally often right as left. --Clinically, at the time of a routine examination or following trauma, chest X-ray reveals an opacity at the base of the thorax, the low and posterior topography of which is suggestive of the diagnosis and and IVP is then indicated. In the absence of violent trauma, the diagnosis of traumatic hernia is eliminated. The distinction between true ectopic kidney and congenital trans-diaphragmatic hernia becomes a false problem since there is no need for treatment in either case.

Child↗
PubMed1980

[Adenocarcinoma developing in a non-functioning tuberculous kidney. One case (author's transl)].

The authors report a case of necrosed carcinoma oif the kidney presenting clinically with fever and a large abdomino-lumbar palpable mass and developing thirty years after functional exclusion of the kidney by tuberculosis. The two particular features were: displacement by the tumour or calcifications in this known mastic kidney, and the poor vascularisation of a necrosed tumour irrigated by an artery of small calibre. The association of tuberculosis and carcinoima, although rare, is no less well known: discovery of a carcinoma in a nephrectomy specimen (for tuberculosis), discovery of tuberculosis in the parenchyma around a carcinoima of the kidney. The rarest possibility remains that of development of a carcinoma of the kidney in a kidney non-functioning and mastic for years, but is sufficiently rare not to be an argument in favour of the excision of all non-functional tuberculous kidneys after adequate antituberculous therapy.

Adenocarcinoma↗