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Biomedical subjects

J Aubert

Publications and source records attributed to J Aubert.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Fulminant gram-negative (CDC-dysgonic-fermenter 2) septicemia in a splenectomized patient].

In a 43-year-old woman admitted because of fever and high cardiac output shock, disseminated intravascular coagulation with purpura was present. The peripheral blood smear revealed the presence of intraleukocytic elongated bacilli, but growth of bacteria (further identified as DF2) in the blood cultures was detected only two weeks after admission. Despite intensive therapy with hemodynamic and respiratory support, associated with broad spectrum antibiotherapy, the patient died on the third day of hospitalisation. The past medical history of the patient revealed splenectomy for Hodgkin's disease 4 years previously, but no recent dog bite.

Adult↗
PubMed1986

[Resection of the inferior vena cava and tumor of the excretory duct: diagnostic and prognostic problems].

The authors present a case of transitional cell carcinoma of the renal pelvis with inferior vena cava involvement. Two types of vena cava involvement are discussed: thrombus or nodes. The CT scan appears to be the best examination to preoperatively diagnose the type of invasion in order to be able to select the optimal treatment. However, these two types of involvement have a poor prognosis and surgery abstention may be justified. Chemotherapy may be useful in these cases.

Adult↗
PubMed1986

[Aberrant renal papilla. Peroperative nephroscopy. Conservative surgery. Apropos of a case].

Principal characteristics of "aberrant papillae" are described, this curious embryologic anomaly being generally detected from the hematuria provoked. Intravenous urography reveals the presence of a persistent lacuna in a calix or of the pelvis, radiologic evidence of the abnormal papilla. Ultrasound and CT scan imaging provide few supplementary data. The most frequent differential diagnosis is from a pyelocaliceal tumor, the known risk of evolutory changes in the latter explaining why most "aberrant papillae" are treated by nephrectomy or even nephroureterectomy. The use of nephroscopy or ureteroscopy should allow, as in the case reported, these abusive nephrectomies to be avoided in the future.

Adult↗
PubMed1986

[Parotid metastases of clear-cell adenocarcinoma of kidney. Apropos of 2 cases].

Two patients presented parotid metastases from adenocarcinoma of kidney. These metastases are rare and may reveal or develop during the course of a cancer of kidney. In the former case diagnosis presents certain difficulties. Treatment of single metastases is by parotidectomy and nephrectomy, prognosis being similar to that of the renal adenocarcinoma.

Adenocarcinoma↗
PubMed1986

[The pedicled lateral flap. Its use in the treatment of anterior hypospadias].

Many methods exist for repair of anterior penile hypospadias but one of the most commonly used is certainly Mathieu's operation. However, this procedure can give rise to different complications due essentially to necrosis of a cutaneous flap brought anteriorly to reconstitute the missing portion of urethra. Based on the pedunculated cutaneous flap described by Blandy for use in urethral shortening, a proposal is made to obtain the flap for canal reconstruction laterally, this allowing conservation of its total vascularization and thus avoiding the risk of ischemic necrosis.

Child↗
PubMed1985

[Inferior vena cava thrombus in nephroblastoma in a child. Diagnostic, surgical and prognostic problems].

The authors report a case of a child Wilm's tumour with inferior vena cava obstruction. The diagnostic, technical and prognostic features are discussed. Ultrasonography appears to be the best diagnostic method to confirm thrombus in the vena cava and allows the choice of an appropriate surgical technique. The presence of vena cava thrombus does not alter the prognosis.

Child, Preschool↗
PubMed1985

[Management of isolated angiomyolipoma of the kidney].

Four patients presented isolated angiomyolipomas of kidney in the absence of any form of phakomatosis such as Bourneville's disease. The tumor was removed by partial nephrectomy in only one case, after histology of a fresh specimen confirming the presence of an angiomyolipoma without signs of cancer. In another patient it was impossible to perform conservative surgery because of dissemination of the angiomyolipoma throughout the kidney. Symptomatology suggestive of the disorder includes lumbar pain, kidney tumor and more rarely hematuria. Diagnosis is difficult despite availability of ultrasound and CT scan imaging, which has supplanted renal arteriography. Confirmation requires histology of a fresh specimen. Operative treatment is essential to avoid the risk of intra- and peri-tumoral hemorrhage, particularly during pregnancy. Partial nephrectomy or excision of tumor is possible when the diagnosis has been established, if excision involves healthy parenchyma and if after strict hemostasis at least one third of renal parenchyma remains.

Adult↗
PubMed1985

[Non-secreting malignant tumors of the adrenals. Apropos of 3 cases].

Tow of three patients seen with malignant tumor of adrenals had very large lesions and the outcome was rapidly fatal. Excision of tumor was possible in the third case and the patient is in good health two years after operation. Clinical signs are infrequent and diagnosis of an adrenal lesion is mainly dependent on combined ultrasound-scan imaging, with confirmation by histology. Differential diagnosis is necessary between adrenal cortex adenoma and pheochromocytoma. Malignancy is suspected from signs of extratumoral invasion and a tumor weight of over 100 g. Histologic findings are not always specific. Treatment is almost exclusively surgical, complementary therapy being unnecessary in non-secreting pheochromocytoma. Attempts to treat malignant adrenal cortex masses by o,p-DDD have not improved prognosis. The chance discovery of a small tumor requires either routine excision of mass to prevent progression of certain malignant tumors, or simple surveillance, particularly after 50 years of age, since many of these tumors are benign: the decision for choice of therapy is a debatable subject.

Adrenal Cortex Neoplasms↗
PubMed1985

[Pregnancy and lithiasis of the upper urinary tract. Clinical aspects and therapeutic management].

Upper urinary tract calculi can be difficult to diagnose and to treat. One has to be aware that there is a risk for the mother which is often not recognized in the long term. The authors describe 17 cases of pregnant women aged between 20 and 33 who were treated for calculi in the Urological Service in Poitiers. They were diagnosed at different stages of pregnancy and a few had a previous urological history. The women presented in different ways, several of them with urinary colic and 10 with urinary colic and fever. Urinary tract infection and septicaemia also occurred. Six patients passed the stones spontaneously. The rest had to be treated by some form of operation, either during the pregnancy or afterwards, including one case of a patient who had to have her kidney and ureter removed and another who had to have a kidney removed. One patient had to have an emergency caesarean section for fetal distress although she had had stone removed at the 20th week of pregnancy. It is not possible to know from this series the incidence of stones in the tract. Various theories of the formation of the stones, including the anatomical changes that occur in the urinary tract in pregnancy, are suggested and these include the hormonal theory of dilatation of the ureters as well as the mechanical theory of changes in the course of the ureters. There are also likely to be changes in the phosphocalcium metabolism. Pain in the lumbar and lower abdominal region is the most frequent symptom occurring in 90-100% of cases and urinary tract infection is common.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Tissue diffusion of flumequine into human renal and prostatic tissues. Assay of flumequine by high performance liquid chromatography after administration of 800 mg/day over 48 hours, the sampling being done 12 hours after the last ingestion].

Diffusion of flumequine into human renal and prostatic tissues was studied. Chemical characteristics and the natural antibacterial spectrum of the compound are described and its rapidity of absorbtion emphasized, blood levels being detected 30 minutes after administration. Maximum plasma levels were reached after 2 to 3 hours and were of the order of 17 mcg/ml, half-life being approximately 10 hours. Plasma protein binding capacity was 60 to 70%, indicating liposolubility enabling diffusion into prostatic parenchyma. Flumequine was recovered in the urine 2 hours after oral administration, maximum urinary concentrations being reached after between 3 and 6 hours, and being of the order of 280 mg/ml after single-dose 40 mg administration. The product was still recovered from the urine 12 hours later, and 60 to 70% of the dose administered after 24 hours, including 20.6% of active form. To evaluate renal and prostatic tissue diffusion 2 series of patients were studied 10 after renal surgery and 14 prostatic operations. Diffusion was excellent into renal parenchyma since the mean ratio between renal tissue and plasma concentrations was 2.41. Urine concentrations were even more extraordinary since the ratio was 136. In contrast, prostatic tissue concentrations were lower than plasma concentrations, the ratio between the two being 0.26, although levels is prostatic tissue were still sufficiently elevated to be effective against germs sensitive to flumequine.

Anti-Infective Agents, Urinary↗
PubMed1985

[Mature retroperitoneal ganglioneuroma in the adult. A case].

Mature ganglioneuroma, a benign nervous tumor of sympathetic origin, is an uncommon diagnosis in adults, particularly when it is located in the retroperitoneal region. Embryology provides an explanation for detection of this tumor in the adrenal glands. The fortuitous discovery of a lesion of this type in a patient with a homolateral renal adenocarcinoma provoked diagnostic and therapeutic problems that are discussed and analyzed.

Adult↗
PubMed1984

Inverted papilloma of the bladder. A report of 10 cases.

The inverted papilloma is a distinct lesion characterized by its rarity compared to the frequency of the other vesical papillomas. The typical histological aspect of this lesion should lead us to call it adeno-urotheliome. Its progress is generally benign. However, the possibility of recurrence indicates a close periodical cystoscopic follow-up.

Adult↗
PubMed1984

[Efficacy and tolerability of Negram Forte in the treatment and prevention of urinary infections in urologic surgery].

The authors sought to assess the efficacy and tolerance of a new oral form of nalidixic acid in the treatment of infections encountered in urological surgery. The study was based upon 30 cases. The urine was considered to be infected when more than 10(5)/ml organisms were present. Amongst 27 patients undergoing surgery, in 26 cases the operation was an endo-cavitary procedure involving the upper or lower urinary tract. The 3 non-surgical cases consisted of one patient with cystitis and two with prostatitis. In 6 patients, treatment was preventive, the urine being sterile before urological surgery. In the other 24, infection was present at the time that treatment was begun. E. coli present in 20 patients was the predominant organism in the series. Tolerance of treatment was perfect in 27 cases. In the 6 cases of preventive treatment, prescription of the drug prevented a postoperative infection. In the 24 patients receiving curative treatment, there were 7 failures (29%) and 3 late recurrences (12.5%). Failures were all the more frequent when the dose was lower. The authors equally felt that the prescription of 4 grams per day in one case was unsuitable. Organisms isolated when treatment was seen to have failed were all resistant to nalidixic acid. In the context of urological surgery, where there is often a cause of reinfection (catheters), the prescription of a high dose of the drug is an essential factor in decreasing the risk factor inherent in treatment.

Adult↗