Search PubMed⌕ Search

Biomedical subjects

J Atkinson

Publications and source records attributed to J Atkinson.

At least 199 records · Page 11Linked to original sources
PubMed1972

A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.

1. Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants.2. The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine.3. Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.

Amitriptyline↗
PubMedDate not supplied

Orientation-specific cortical responses develop in early infancy.

Neurones in the visual cortex of higher mammals differ from those elsewhere in the visual pathway in that the majority respond selectively to particular edge or bar orientations in the stimulus. We have developed a visually evoked potential (VEP) technique which isolates the response of orientation-selective mechanisms from that of cortical or sub-cortical neurones which lack orientation selectivity. We are unable to find such orientation-selective responses in newborn human infants within the sensitivity of our method, but repeated longitudinal testing of individual infants shows that measurable responses emerge around 6 weeks of age. This result is consistent with the idea that human cortical visual function is very immature at birth, but develops rapidly in the first two postnatal months.

Age Factors↗
PubMedDate not supplied

Blood pressure overshoot under pentobarbitone anaesthesia following a single dose of clonidine in rats.

1. Withdrawal of chronic antihypertensive therapy with clonidine is known to produce a blood pressure overshoot. It has been reported that the same may occur after a single dose of clonidine. 2. A single, intramuscular dose of clonidine (0.05 mg/kg) produced an overshoot in blood pressure, on the day following administration, in normotensive rats anaesthetized with sodium pentobarbitone. 3. No rebound elevation of mean arterial pressure or of heart rate occurred in conscious, normotensive, spontaneously hypertensive or renal hypertensive rats following this dose of clonidine, nor did it occur in rats anaesthetized with ether. 4. It is suggested that the overshoot phenomenon in rats under barbiturate anaesthesia may involve an interaction between an effect of clonidine and the barbiturate.

Anesthesia, General↗
PubMedDate not supplied

Bearing witness.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗