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Biomedical subjects

J Assheuer

Publications and source records attributed to J Assheuer.

At least 55 records · Page 3Linked to original sources
PubMed1988

Intravenous natural beta interferon treatment of chronic exacerbating-remitting multiple sclerosis: clinical response and MRI/CSF findings.

A preliminary study is reported of clinical response and CSF/MRI findings in nine patients with multiple sclerosis receiving intravenous infusions of natural beta-interferon. The mean patient follow-up was for 1.2 years. Neither exacerbation rates nor CSF-IgG synthesis nor plaque formation as revealed by MRI showed a significant reduction during therapy. One patient developed a severe exacerbation of multiple sclerosis shortly after interferon infusion.

Adolescent↗
PubMed1988

[Early functional and structural changes in the nerve tissue following contact with chymopapain].

Using magnetic resonance imaging, conventional histology, and spinal evoked potentials, the authors studied the short-term effects of chymopapain on nerve tissue in the lumbar vertebral canal region in rats. Chymopapain in different concentrations was injected into the subarachnoid space in 31 rats. As early as 20 minutes later latency changes in the evoked potentials were observed; the histologic examinations after two hours showed bleeding, swelling of the myelin, and vascular changes. Magnetic resonance imaging of the lumbar spine, performed after six hours, showed a markedly stronger signal, indicative of an intraspinal edema, as compared to the control group. The authors' studies are clear proof that changes in nerve tissue following contact with chymopapain occur considerably faster than hitherto assumed in the literature.

Animals↗
PubMed1987

[Fat/water separation in the NMR tomogram. The imaging of bone marrow reactions in degenerative intervertebral disk changes].

We examined 410 patients with lumbar disc degeneration. In 23% fat suppressing IR sequences and phase contrast techniques displayed marrow reactions in subchondral bone adjacent to the affected discs. Only in some cases conventional MRI sequences were able to depict these marrow reactions. CT, plain X-ray and scintigraphy did not show marrow changes. Bacterial infection was excluded. Histological analysis showed substitution of haematopoietic marrow by fatty tissue, necrobiosis and increase in mucoid extracellular fluid.

Bone Marrow↗
PubMed1986

[Additional examinations for ascertaining the diagnosis of multiple sclerosis].

The relevance of additional findings was examined in 50 patients in whom multiple sclerosis had been diagnosed. Magnetic resonance (MR) technique revealed morphological changes in 49 patients (688 foci), whereas CT scan visualised foci with modified enhancement in 35 patients only (133 foci) (70%). Oligoclonal antibodies were found in the CSF of 96% of the patients as pointers towards the inflammatory immunological process. Enhanced daily IgG production was seen in 57-70% of the patients, whereas in 52% stimulated lymphocytes were identified in the CSF. Total protein content and cell count in the CSF differed in only 22 and 26%, respectively. Functional deterioration of the myelin sheath resulted in 72% of MS patients in an increased latency of visually evoked potentials. Hence, oligoclonal antibodies in the CSF and multiple foci revealed by MR are the most reliable additional findings in MS and should be considered as essential aids to confirm the diagnosis. A modified schema is suggested in which CT is replaced by MR and the proof of oligoclonal antibodies is given a higher ranking. Pathological changes in evoked potentials are relevant only if clinical symptoms are absent. Sensitivity disturbances and manifestations of brain stem disorders are somewhat less significant.

Adult↗
PubMed1985

[Nuclear spin resonance tomography and its anatomic-pathological correlates].

NMR examination of a preserved head was performed using different Inversion Recovery and Spin Echo sequences. Correlations were made between the MR and the macroscopic pathological and later, the histological appearances of the specimen at corresponding slices. Normal anatomical structures and the multiple pathological lesions were all clearly demonstrated by MRI.

Aged↗