[New diagnostic systems--technics, efficiency and limitations. Cholangiography. a) ERCP].
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Biomedical subjects
Publications and source records attributed to J Ariyama.
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During a period of 18 months, intraarterial digital subtraction angiography (IADSA) was performed in 360 patients with various gastrointestinal disorders. This technique was useful both in diagnostic and interventional procedures. Due to increased contrast resolution, hepatic tumors and portal vein systems were better visualized than with the use of conventional angiography. Also, a significant reduction in the dosage of contrast medium resulted in markedly reduced patient discomfort. Small pancreatobiliary tumors were better evaluated on conventional angiograms due to the decreased spatial resolution of IADSA.
The diagnosis of small pancreatic carcinoma is difficult since specific tumor marker is not currently available. Diagnostic modalities are used to evaluate patients in whom pancreatic carcinoma is clinically suspected. US is frequently used as a screening procedure. Should this be abnormal, a lesion is confirmed by CT. If not ERCP is indicated. If ERCP reveals an abnormality, angiography is performed to determine whether the lesion is benign or malignant. Between 1972 and 1984, 150 pancreatic carcinomas have been diagnosed. Thirty-nine tumors were less than 3 cm, and the smallest lesion measured 9 mm. Four-year survival rate of small resectable tumors is 40%.
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Endoscopic Retrograde Choledocho-Pancreatography, Ultrasonography and Computer Tomography can show dilated pancreatic duct in the patients with small resectable pancreatic carcinoma. However they can not predict the size of the tumor. Angiography is a complementary examination, being able to demonstrate the size of the tumor and predict its resectability.
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Clinical symptoms and abnormality of laboratory examinations in 62 patients with proven pancreatic carcinoma were studied. The following indications for detailed examination of the pancreas have been evolved: (1) vague abdominal symptoms, (2) jaundice, (3) abnormalities of laporatory examinations including serum LAP, ALP, amylase and cholinesterase level, and abnormal GTT. In the jaundiced patient the initial examination is US followed by PTCD to relieve the jaundice, and then angiography to assess resectability of the tumor. In the non-jaundiced patient US is used as a screening procedure. Should this be abnormal a lesion may be confirmed by CT. If not ERCP is indicated when there is some distinct reason to suspect pancreatic disease. If ERCP reveals abnormality then angiography is performed to determine whether the lesion is benign or malignant, and if malignant it is resectable or not. In the period of 1968 and 1981, 112 proven pancreatic carcinomas were studied. Overall resectability was 26%. Thirty tumors were less than 3 cm and the smallest lesion measured 1.2 cm.
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Efficacy of double contrast X-ray study of the bile duct was studied. Using barium sulfate it was possible to demonstrate fine mucosal pattern (FMP) of the bile duct in the surgical specimen. Utilizing decompression catheter in 44 patients with extrahepatic jaundice, double contrast study was clinically performed. It was also possible to demonstrate FMP of the bile duct mucosa. Mucosal and intramural spread of bile duct carcinoma were revealed preoperatively. It was also useful in the differential diagnosis of the biliary tract diseases.
Gastroduodenal erosions were observed endoscopically and shown by double-contrast radiology in nine of 38 patients who had established Crohn's disease elsewhere in the intestinal tract. One of the nine patients was known to have duodenal involvement by Crohn's disease, but in the other eight there was no clinical suspicion of upper gastrointestinal disease. The possible significance of this finding is discussed.
Our investigations have shown that only those carcinomas of the pancreas of less than 3 cm. can be cured. In our experience the only way to diagnose such tumours preoperatively is a combination of angiography, ERCP and/or percutaneous transhepatic cholangiography.
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