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Biomedical subjects

J Arditti

Publications and source records attributed to J Arditti.

17 recordsLinked to original sources
PubMed1992

[Buprenorphine abuse in a series of 50 drug addicts hospitalized at a Drug Dependence Evaluation hospital in Marseille].

Buprenorphine, a synthetic central analgesic, marketed since 1987, was rapidly suspected to be subject to abuse. We tried to confirm this abuse in the context of our analytical activity at the Drug Dependence Evaluation and Information Centre. The study was based on 50 drug addicts admitted to Marseille Hospital between June and October 1992. Buprenorphine and its N-dealkylated metabolite were identified in the urine by high performance liquid chromatography equipped with a diode array detector. Nine (18%) of the 50 samples analysed were positive for buprenorphine and/or norbuprenorphine, with a confidence interval of 8 to 28%, which confirms the existence of abuse of this analgesic.

Adult↗
PubMed1983

[Toxicity and dangers of volatile nitrites sold in sex shops].

The authors report a case of methemoglobinemia following a suicidal attempts with a popper containing isobutyl nitrite. The toxic effects of this substances, either by ingestion or inhalation, are described as well as risks of use in "everyday life". Regulations, still incomplete has been suggested in USA. In France, preventive measures should be taken.

Adult↗
PubMedDate not supplied

[Experimental study of the toxic convulsant properties of commercial preparations of essences of sage and hyssop (author's transl)].

Commercial preparations of essences of sage and hyssop have caused poisoning of human beings and were found to possess a convulsant action of central origin in animals. The convulsant effect of hyssop essence appears to be more powerful than that of sage in non-anaesthetized rats. The dose limit, below which the cortical phenomena are subclinical, is 0.08 g/kg for hyssop, while above 0.13 g/kg convulsions appear and become lethal above 1.25 g/kg. The same doses for essence of sage are respectively 0.3, 0.5 and 3.2 g/kg. The neurotoxicity of hyssop appears to be related to the presence of two terpene ketones, pinocamphone and isopinocamphone, the former of which has powerful convulsant properties, and is lethal at doses above 0.05 ml/kg. The toxicity of essence of sage is due to the presence of camphor which is well-known to possess convulsant properties.

Animals↗
PubMedDate not supplied

[Local anesthesia in ambulatory phlebectomy by the method of R. Muller: risk assessment by lidocaine dosage].

Local anesthesia for ambulatory phlebectomy makes it necessary to inject a considerable quantity of lidocaine. This study involved 50 operations. The doses of lidocaine containing 1% adrenaline and injected after cooling (between 2 and 5 degrees C) ranged from 200 mg to nearly 900 mg in a single administration. The assays of lidocaine in the peripheral venous blood were carried out by means of F.P.I.A. (Fluorescence Polarization Immuno Assay) at times 0, 30 min 60 min, 90 min., 24 hours and 48 hours. The peak concentration obtained (1.8 micrograms/ml) for a dose of 700 mg in a subject weighting 65 kg, i.e. 10.9 mg/kg, was only one-half the concentration considered to be neurologically toxic (4 to 12 micrograms/ml) or one-twelfth of the toxic levels with regard to the cardiovascular system (24 micrograms/ml). The performance of local anesthesia in the physician's office is devoid of major risks, even though the doses used during AP are much higher than those usually administered in routine dematological surgery.

Adult↗