Serum cholesterol in Chilean newborn infants and its evolution during the first months of life. Comparison between breast fed infants and those fed a cow's milk formula.
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Animals↗
Biomedical subjects
J Anselmo
Publications and source records attributed to J Anselmo.
Resistance to thyroid hormone: report of 2 kindreds with 35 patients.
OBJECTIVE: To report two kindreds with resistance to thyroid hormone (RTH), particularly the clinical and laboratory evolution after thyroidectomy and with antithyroid drug treatment. METHODS: Clinical data and thyroid function were determined in 82 members from three different generations of both families. Unaffected relatives were used as a control group. Response of thyroid-stimulating hormone (TSH) to the hypothalamic thyrotropin-releasing hormone (TRH) was evaluated in five patients and compared with five nonaffected relatives. RESULTS: Thirty-five (22 male and 13 female) patients had high serum levels of thyroxine and triiodothyronine in conjunction with nonsuppressed TSH. Goiter was present in 66% of affected family members; prevalence was 10% in childhood and 88% in adulthood. The prevalence of goiter was 18% in nonaffected relatives. No patient showed evidence of thyroid hypofunction or hyperfunction, and the TSH response to TRH was similar to that of nonaffected relatives. The incidence of RTH in offspring was 60%, consistent with autosomal dominant transmission. Four patients had undergone thyroidectomy, and two required a second operation because of recurrence of goiter. Patients who had undergone thyroidectomy had normal or near-normal levels of thyroid hormone and very high values of TSH despite thyroid hormone therapy. Five patients were treated with antithyroid drugs for 2 to 10 years, but their thyroid function remained similar to that of nontreated patients. CONCLUSION: RTH is a relatively rare and benign condition that can be misdiagnosed as hyperthyroidism. The disease is responsible for a high prevalence of goiter in affected families. Thyroidectomy and treatment with antithyroid drugs are not indicated and may have lifelong implications.
Journal Article↗
[Chronic hypoparathyroidism: review of 5 clinical cases].
In 5 patients with a long clinical evolution of tetany and/or convulsions and with documented hypocalcaemia and hyperphosphatemia, low or inappropriate values of parathormone were detected. Only two of the patients had a history of subtotal thyroidectomy and all presented with basal ganglia calcification, bilateral subcapsular cataracts and prolonged QTc interval in the ECG. After one month of oral therapy with calcium and calcitriol, the values of calcaemia and phosphatemia were in a near-normal range with the exception of a patient in which that normalization was much slower and only occurred after correction of magnesaemia. In this last patient statistical correlation between QTc interval in the ECG and the calcaemia was statistically significant (P less than 0.001). We conclude that the QTc interval can be a useful and accessible index in acute situations of symptomatic hypocalcaemia.
Adult↗
[Influence of body fat topography on glucose homeostasis and serum lipids].
Predominant fat distribution in the upper body segment evaluated by waist to hip circunference ratio (WHR) has been associated with diabetes mellitus and cardiovascular morbidity excess. To investigate metabolic alterations underlying this risk excess, we selected 2 groups of 10 obese women without history of hypertension, menstrual irregularities or oral contraceptives, matched according to age (mean +/- SD): 30.5 +/- 5.3 vs 30.6 +/- 5.8 years and BMI 35.5 +/- 6.5 vs 35.7 +/- 6.7 Kg/m2. Each matched pair had a difference in WHR superior to 0.15 (0.83 +/- 0.04 vs 1.02 +/- 0.05). Insulin and C peptide were determined during an oral glucose tolerance test (75 g). At 30, 60, 90 and 120 minutes differences were significant for glycaemia, insulinaemia and C peptide. Fasting triglycerides were 103 +/- 48 in the lower WHR group vs 164 +/- 84 mg/dl (p less than 0.05); total cholesterol 186.5 +/- 31 vs 215.2 +/- 29.4 mg/dl (p less than 0.05); LDL cholesterol/HDL cholesterol 2.46 +/- 0.89 vs 3.18 +/- 0.96 (p less than 0.05). No significant differences were found in androgenic activity. We conclude that preferential fat distribution in the upper segment is, by itself, an aggravating factor of metabolic alterations associated with obesity, particularly dyslipidaemia and hyperinsulinaemia.
Adipose Tissue↗