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Biomedical subjects

J Anderson

Publications and source records attributed to J Anderson.

1,128 records · Page 63Linked to original sources
PubMedDate not supplied

Comparison of the therapeutic response of patients with childhood acute lymphoblastic leukemia in relapse to vindesine versus vincristine in combination with prednisone and L-asparaginase: a phase III trial.

One hundred and seventy-nine previously treated children with acute lymphoblastic leukemia in relapse considered not "resistant" to vincristine (VCR) were randomly allocated to receive reinduction therapy with either vindesine (VND) or VCR, in combination with prednisone and L-asparaginase. Complete remission rates were 57% for both regimens and were significantly greater for first relapsers (69%) than for subsequent relapsers (43%). No significant difference in response rates by regimen was observed within relapse groups. Patients treated with VND experienced significantly greater hematologic toxicity. These data suggest that there is no advantage to using VND instead of VCR in standard reinduction therapy for childhood acute lymphoblastic leukemia in relapse.

Asparaginase↗
PubMedDate not supplied

Pathophysiological basis of burn management.

Despite increased public awareness of the dangers of fire, burns remain a part of everyday life. Most accident departments will see one or more burn victims each day and, although not common, major burns still occur. In this and a second article we review the pathophysiology of thermal injury and describe the early treatment of a major burn victim.

Burns↗
PubMedDate not supplied

The early management of large burns.

The first article in this series (Vol 52 (11), p.583) discussed the pathophysiological processes involved in burn injury. This article describes the early management of large burns, in which treatment is considered in four stages: resuscitation, assessment, further care and transfer. The mnemonic 'RAFT' is suggested as a means of assisting recall of the management process.

Burn Units↗
PubMedDate not supplied

An evaluation of heart health education for Southeast Asians.

We present data on the effects of a heart health education intervention targeted at adult Southeast Asians. Within each of the Cambodian, Laotian, and Vietnamese groups who received the intervention, we obtained random samples approximately three to 18 months postintervention. Comparisons were made between preintervention and postintervention knowledge of blood pressure and awareness of behaviors to prevent heart disease. Within all three ethnic samples, we found significant increases in the pre-to-post percentages of individuals who could define blood pressure and identify ways to prevent heart diseases.

Adult↗
PubMedDate not supplied

Contraceptive and sexual practices among single women with an unplanned pregnancy: partner influences.

Data from an urban obstetrics clinic on 291 unmarried women with a current unplanned pregnancy show that women with only one partner in the past year are older and are more likely to use the most effective contraceptive methods than are women who have more than one partner. Women with only one partner are also more likely to be solely responsible for decision-making about the choice of contraceptive methods, and are not as likely to use drugs in conjunction with sex. However, women with one partner are also less likely than others to use condoms or to protect in some other way against sexually transmitted diseases or the human immunodeficiency virus.

Adolescent↗
PubMedDate not supplied

Munchausen syndrome by proxy.

This article provides an overview of Munchausen syndrome by proxy. It examines current definitions and looks at the varied clinical presentations. The characteristics of the perpetrators are described with a view to aiding early identification and intervention.

Child↗
PubMedDate not supplied

Impact of prolonged saline solution prime exposure on integrity of extracorporeal membrane oxygenation circuits.

OBJECTIVE: Our purpose was to evaluate the safety of the common practice of preparing extracorporeal membrane oxygenation (ECMO) circuits in advance with saline solution priming by analysis of the surfaces of circuit components and analysis of the prime solution for toxic contaminations. STUDY DESIGN: In vitro analysis of eight ECMO circuits exposed to saline prime solution for 0, 2, or 4 weeks was performed with scanning electron microscopy. Prime solution analyzed for contamination with aluminum, silicone, and diethylhexylphthalate. RESULTS: The silicone membrane and heat exchanger demonstrated surface degradation in contact with saline solution. The prime solution showed increasing concentrations of both aluminum and silicone but not diethylhexylphthalate over time. CONCLUSIONS: Advance preparation of ECMO circuits by prepriming with normal saline solution leads to significant circuit degradation. Prepriming should be avoided.

Aluminum↗
PubMedDate not supplied

Management of constipation in the critically ill patient.

Teamwork and a well-known problem-solving technique are used to give a flexible solution to the problem of bowel management in the critically ill patient. A literature review of constipation is linked to treatment of the critically ill patient. General and specific factors are discussed including nasogastric feeding pharmacology. Design and implementation of a protocol for bowel management for patients in the intensive care field of nursing are demonstrated.

Algorithms↗