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Biomedical subjects

J Ammon

Publications and source records attributed to J Ammon.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Portal films and daylight film developing].

Automatic daylight film handling systems in radiotherapeutic departments are useful to process simulation films. Plastic film cassettes with two polished stainless steel screens (2 mm at the front and 0.5 mm at the back) instead of the fluorescent intensifying screens are used. Regular diagnostic films are exposed with five monitor units. Loading and unloading of the cassettes are performed automatically. Exposed films are rapidly available with sufficient quality.

Automation↗
PubMed1990

[Detection of bone marrow involvement in breast cancer and malignant lymphoma using immunoscintigraphy of the hematopoietic bone marrow].

Radioimmunoimaging of bone marrow was performed for non-invasive detection of skeletal involvement in 15 patients with carcinoma of the breast and 17 patients with malignant lymphomas. Bone marrow scans were performed by means of a monoclonal 99mTc-labelled antibody, directed against NCA-95 and CEA. The presence and extent of skeletal involvement were controlled by skeletal scintigraphy, plain radiographs and CT; bone marrow biopsies were obtained in 19 patients as well. 20 subjects without suspected malignant disease served as controls. Haematopoietic bone marrow was imaged homogeneously and with high contrast in all controls. 15/15 patients with carcinoma of the breast and 10/17 patients with malignant lymphomas had multifocal bone marrow defects due to skeletal metastases. Bone marrow scans revealed significantly more lesions than skeletal scintigraphy both in carcinoma of the breast (p = 0.027) and malignant lymphomas (p = 0.015). Thus, radioimmunoscintigraphy of bone marrow may provide a new, sensitive approach for non-invasive detection of metastatic spread to the skeletal system.

Adult↗
PubMed1989

Radioimmunoimaging for diagnosis of bone marrow involvement in breast cancer and malignant lymphoma.

Granulopoietic bone-marrow was scintigraphically imaged in 15 patients with carcinoma of the breast and known skeletal metastases, 10 patients with malignant lymphomas, and 15 controls without suspected malignant disease, with a technetium-99m labelled murine monoclonal IgG1 antibody directed against nonspecific cross-reacting antigen (NCA-95) and carcinoembryonic antigen. Immunoscintigraphy revealed more lesions than did bone scanning in both patient groups. This method offers a sensitive, cost-effective, and easy-to-perform whole body technique for evaluating metastatic spread.

Antibodies, Monoclonal↗
PubMed1989

[Treatment planning based on oncologic signs of malignant tumors--consequences for breast cancer].

Although the carcinoma of the female breast is characterised by a special invasive behaviour, many of its features apply likewise to other types of tumour. This results in treatment concepts aimed at curing the disease, partly also at preserving the organ itself. Treatment with a palliative aim has received new impulses by discussing a closely meshed and individual follow-up plan that identifies relevant metastases even before they become clinically manifest. The consequences of this approach will contribute significantly towards an improvement of the quality of life of the patients concerned.

Breast Neoplasms↗
PubMed1984

[Extragonadal germ cell tumors--diagnostic and therapeutic aspects].

The extratesticular manifestation of a tumor of the germ cells without apparent involvement of the testicle is a rare disease. During the last few years, seven patients with extragonadal tumors of the germ cells have been treated at our hospital. Tumor site was the retroperitoneum in four patients and the mediastinum, the lung, and the pineal body in one patient each. Based on the clinical courses of the seven cases, the authors discuss the diagnostic and therapeutic experiences with extragonadal tumors of the germ cells of various histologies and localizations. In order to make possible a curative therapy, the treatment should be performed according to the therapeutic conceptions existing for comparable histologic grades of primary testicle tumors.

Adult↗
PubMed1982

[Postoperative radiotherapy of astrocytomas grade 3 and 4 with the radiosensitizer misonidazole. -End results of a multicentric controlled German study].

102 patients entered a multicentric randomized study from May 1978 till December 1980. After an operative removal of a supratentorial astrocytoma grade 3 or 4 all patients were treated by radiotherapy of the whole brain with 40 Gy, and after a rest of 1 to 2 weeks with a boost dose of 20 Gy to the tumor region. By randomization the patients got misonidazole (400 mg/m2) to each of the 30 fractions or a placebo. The overall tolerance was good. A mild transient peripheral neuropathy was seen only in 2 patients. The median of survival time was not significantly different for both groups with 16 months (grade 3) and 10 months (grade 4). Thus a radiosensitizing effect of misonidazole was not proven.

Adolescent↗