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Biomedical subjects

J Adkins

Publications and source records attributed to J Adkins.

15 recordsLinked to original sources
PubMed1997

Adenoid cystic carcinoma developing in the nasal orbit.

PURPOSE: To describe the clinical, imaging, and histopathologic findings of an adenoid cystic carcinoma that occurred in the medial orbit. METHODS: A 26-year-old man developed a painless soft tissue mass in the nasal aspect of the left orbit. Computed tomography was done, and incisional biopsy performed elsewhere disclosed adenoid cystic carcinoma. Orbital exenteration was performed. RESULTS: Computed tomography showed a 1.5cm mass in the antronasal region of the orbit without bone erosion. Histopathology disclosed adenoid cystic carcinoma. CONCLUSIONS: Although orbital adenoid cystic carcinoma usually originates superotemporally in the main lacrimal gland, it can develop in the nasal orbit, possibly from ectopic lacrimal gland tissue. Adenoid cystic carcinoma should be included in the differential diagnosis of tumors of the nasal orbit.

Adult↗
PubMed1991

Results of treatment of malignant germ cell tumors in 93 children: a report from the Childrens Cancer Study Group.

We report treatment results in 93 children entered on study from 1978 to 1984 with malignant germ cell tumors (MGCTs), excluding dysgerminoma and tumors of the testis or brain. The estimated 4-year survival and event-free survival (EFS) for all 93 patients were 54% and 49%, respectively. For 30 children with ovarian tumors, the estimated 4-year survival was 67% and EFS was 63%. For 63 children with nongonadal tumors, survival and EFS were 48% and 42%, respectively. The comparison of EFS between ovarian and nongonadal tumors was significant at P = .03. The treatment plan included a second-look surgical procedure after 18 weeks of chemotherapy. Over half of 36 patients evaluated as having a residual mass present immediately before second-look surgery had no malignant tumor after review of surgical specimens. Age greater than 11 years at diagnosis, incomplete removal of tumor at first surgery, and more than one structure or organ involved at diagnosis increased the risk for adverse event. The histologic subtype of the primary tumor was not related to outcome. Diagnosis was verified by independent pathologic review, and treatment was uniform. Seventeen percent of all registered patients (21 of 127) were excluded because of ineligible pathologic diagnoses; sixty percent (13 of 21) were immature teratomas.

Adolescent↗
PubMed1988

Effects of beta-carotene and retinyl palmitate on corn oil-induced superoxide dismutase and catalase in rats.

The present study was undertaken to determine the effects of beta-carotene on corn oil-induced superoxide dismutase and catalase. Six groups of male Buffalo rats were fed the following diets for 6 wk: a control diet containing recommended levels of beta-carotene and retinyl palmitate, a retinol diet containing 10 times the recommended level of retinyl palmitate, and a beta-carotene diet containing 10 times the recommended levels of beta-carotene and adequate levels of retinyl palmitate. Each vitamin combination was fed with either 5% (wt/wt) corn oil (low fat) or 20% corn oil (high fat). Plasma total beta-carotene levels were highest in the beta-carotene groups. Levels varied inversely with the level of fat in the control group and directly with fat in the beta-carotene group. Transport of beta-carotene appeared to parallel that of cholesterol in that 36 and 35%, respectively, were associated with the low density lipoprotein fraction. Accumulation of beta-carotene in the liver was apparent from the observation that levels in liver were much higher than those in plasma. Superoxide dismutase activity was much lower in the beta-carotene groups than in the retinol groups, irrespective of level of fat, and catalase activity was also lower in the beta-carotene group, but it was in proportion to the level of fat. These findings suggest that beta-carotene functions as an antioxidant in vivo.

Administration, Oral↗