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Biomedical subjects

J Abril

Publications and source records attributed to J Abril.

4 recordsLinked to original sources
PubMed2003

Cardiovascular morbidity and obesity in adult liver transplant recipients.

There is a direct relationship between the grade of obesity and mortality based on the increased cardiovascular diseases, cancer, etc. However, the results of studies in renal and liver allograft recipients relating obesity to morbidity and mortality are contradictory. A retrospective cohort study of 170 patients transplanted between March 1987 and July 1997 showed obesity to be identified in 77 (45.3%) patients. During the mean follow-up of 5 years posttransplantation, 16 (9.4%) patients experienced cardiovascular complications, including 10 patients with ischemic cardiac syndromes (five acute infarctions and five angina), five patients with acute cerebrovascular accidents, and one patient with intermittent lower limbs claudication. The prevalence of obesity at 1, 3, 5, 7, and 9 years after transplantation was 58.2%, 56.9%, 60.3%, 59.5%, and 66.4%, respectively. Compared with the baseline value, the BMI was increased at 1 year posttransplantation (25.78), a significant difference. No significant differences were found between the mean BMI values of patients with and without cardiovascular diseases, or overweight and morbidly obese patients compared to the normal weight population. Among liver transplant recipients, obesity was a frequent complication after transplantation, but it was not clearly associated with increased morbidity and mortality secondary to cardiovascular disease.

Adult↗
PubMed2001

Optical measurement of cardiac rhythm using a personal computer with telediagnosis possibilities.

A system that enables the automatic measurement of cardiac rhythm and the quantity of oxygen in the blood has been designed, constructed, and patented. Equipped with the appropriate software, this system registers this information and represents it numerically, in the form of a graph, which can then be printed as a detailed record of cardiac rhythm. This system aids in the determination of cardiac pathologies, and also enables the information to be sent to medical professionals to perform telediagnosis. The apparatus is based on the measurement (sampling) of noninvasive medical parameters. The apparatus is intended to cover a broad range of requirements and needs, as can be used by medical professionals (to detect pathologies related to the pumping and circulation of blood in the body) as well as by lay people who might wish to monitor or gain information concerning their cardiac rhythm and the general functioning of their heart. Thus, the system is designed to be clear and concise in its information as well as easy to use, especially for people unrelated to the medical profession. The way to constructing this system is explained in detail.

Cardiovascular Diseases↗
PubMed2000

Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.

UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the RAD6-mediated error-free DNA repair pathway. In mammalian cells, UEV proteins can modulate c-FOS transcription and the G2-M transition of the cell cycle. Here we show that the UEV genes from phylogenetically distant organisms present a remarkable conservation in their exon-intron structure. We also show that the human UEV1 gene is fused with the previously unknown gene Kua. In Caenorhabditis elegans and Drosophila melanogaster, Kua and UEV are in separated loci, and are expressed as independent transcripts and proteins. In humans, Kua and UEV1 are adjacent genes, expressed either as separate transcripts encoding independent Kua and UEV1 proteins, or as a hybrid Kua-UEV transcript, encoding a two-domain protein. Kua proteins represent a novel class of conserved proteins with juxtamembrane histidine-rich motifs. Experiments with epitope-tagged proteins show that UEV1A is a nuclear protein, whereas both Kua and Kua-UEV localize to cytoplasmic structures, indicating that the Kua domain determines the cytoplasmic localization of Kua-UEV. Therefore, the addition of a Kua domain to UEV in the fused Kua-UEV protein confers new biological properties to this regulator of variant polyubiquitination.

Amino Acid Sequence↗