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Biomedical subjects

J Abramson

Publications and source records attributed to J Abramson.

46 records · Page 3Linked to original sources
PubMed1976

Anti-inflammatory drug treatment in Crohn's disease.

In a prospective evaluation of all patients with Crohn's disease treated by us since 1970, 62 have completed at least one year, or required bowel resection after at least three months, of anti-inflammatory drug treatment. Sulfasalazine alone was used in 24 patients, steroids alone were used in four patients, both drugs were used together in 29 patients and azathioprine was added to the drug regimen of five patients. The initial choice of drug followed a set design but the regimens ultimately arrived at depended upon patient responses. Favorable complete or partial clinical responses were obtained in 54 patients, while 37 patients showed objective radiographic improvement or regression. No radiographic improvement was found in the eight patients with clinical treatment failure as well as in 11 patients with clinical improvement. Six clinically improved patients had not yet been re-examined radiographically. The study provides objective evidence that the majority of patients with Crohn's disease can be successfully treated by means of anti-inflammatory drugs.

Anti-Inflammatory Agents↗
PubMed1976

Ileojejunitis in a pair of identical twins.

A pair of identical twin brothers with identical white and red blood cell antigens and diffuse ileojejunitis is reported. One brother initially presented with granulomatous gastritis, presumably Crohn's disease of the stomach. The relationship of diffuse ileojejunitis to Crohn's disease and the suspected genetic predisposition to develop Crohn's disease are briefly discussed.

Adolescent↗
PubMedDate not supplied

Granulocyte transfusion therapy in chronic granulomatous disease. Report of a patient and review of the literature.

A l6-year-old boy with chronic granulomatous disease (CGD) and multiple Staphylococcus aureus hepatic abscesses failed to respond to intense antimicrobial therapy and surgical drainage procedures. He was started on a l3-day course of daily granulocyte transfusions obtained by intermittent-flow leukapheresis (haemonetics Model 30 [Braintree, Massachusetts]) utilizing hydroxyethyl starch. Each transfusion contained an average of 9 X l0(9) granulocytes. He defervesced on the seventh transfusion day, and the sedimentation rate returned to normal on the thirteenth transfusion day. Radionuclide scan showed decrease in size of the liver abscesses. No other new therapeutic modalities were attempted during the period of granulocyte transfusion. Although the use of granulocyte transfusion has been suggested to treat infections in CGD, we report the first successful use of granulocyte transfusion therapy in S. aureus abscess disease in CGD. Granulocyte transfusions may be helpful in treating infections refractory to standard medical-surgical management in patients with CGD and other disorders of neutrophil function.

Adolescent↗
PubMedDate not supplied

Should we screen for lead poisoning after 36 months of age? Experience in the inner city.

INTRODUCTION: Current lead screening guidelines recommend monitoring lead levels in children under 3 years of age. There are, however, a number of children between the ages of 3 and 6 years who have elevated blood lead levels. Whether these lead elevations are new or chronic has not been examined. OBJECTIVE: To determine the proportion of children with lead levels greater than or equal to 10 microg/dL after their third birthday when all prior testing had been normal. METHODS: Retrospective study based on 39000 venous lead tests obtained between 1993 and 1998. From this group, 2046 children were located who had blood lead levels of less than 10 microg/dL before 36 months and who had a follow-up lead level after 36 months. All lead assays were done by the City of New York laboratories, which had an intrasample variability of 13%. RESULTS: Sixty-six (3.2%) of the 2046 children showed an elevation in blood lead for the first time after their third birthday. The abnormal values ranged from 10 to 25 microg/dL. The majority (72%) of the screen-positive children, however, had lead levels of 10 to 12 microg/dL, and 63.3% of screen-positive children with repeat tests had lead levels that reverted to below 10 microg/dL. CONCLUSIONS: The data indicate that some new cases of lead level elevations did occur after 3 years of age in this 'high-risk' community; however, the current study provides evidence that universal screening for lead poisoning beyond 3 years of age is not warranted in this community as it is not likely to pick up clinically important exposure.

Age Factors↗
PubMedDate not supplied

A highly stable methyl cellulose coating for capillary electrophoresis.

A highly stable capillary-coating has been created by coupling covalently a hydroxyl group of methyl cellulose to the epoxy group of alpha-glycidoxypropyltrimethoxysilane attached to a piece of fused silica tubing. This coating strongly suppresses electroendosmotic flow (EOF) and minimizes sample adsorption onto the capillary wall for several weeks or months. The stability of the coating has been tested with isoelectric focusing and free zone electrophoresis. The coupling procedure is easy to perform, and the coating withstands at least 135 consecutive runs under extreme pH conditions (2-12). EOF is still reduced after placing the coated capillary in 0.01 M NaOH for 30 days. A detailed description of the coating procedure is provided.

Electrophoresis, Capillary↗