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Biomedical subjects

J Abdullah

Publications and source records attributed to J Abdullah.

32 records · Page 2Linked to original sources
PubMed1999

Analysis of brain tumours suitable for curability via gene therapy in North East Malaysia.

Two hundred primary brain tumours in both adults and children from the year 1990 to 1998 presenting for treatment to the Neurosurgical Division of the Hospital of the University of Sciences Malaysia were studied retrospectively. Volumes of tumours were taken from CT scans with contrast using two formulas and divided into 4 groups: (1) less than 20 cm(3), (2) 20-50 cm(3), (3) 50-100 cm(3) (4) larger than 100 cm(3). The majority of the brain tumours were in the volume range of 50-100 cm(3), and are thus potentially curable with retroviral gene therapy.

Adult↗
PubMed1999

Use of bovine xenograft in reconstruction of traumatic anterior cranial fossa bone defects involving the frontal sinus.

Four patients underwent reconstruction of anterior cranial fossa of skull defects between November 1997 and January 1998. All of them had traumatic anterior cranial fossa defect and were reconstructed with lyophilised bovine cortical bone graft. There was no cerebrospinal fluid leakage, meningitis, extradural abscess or other infections. This study demonstrates that the use of bovine bone graft in the reconstruction of anterior base defects is safe.

Adolescent↗
PubMed1998

Endoscopic neurosurgery: report of the first five cases done in Malaysia using the Caemaert-Abdullah method.

The first endoscopic procedure done in Malaysia using the Caemaert-Abdullah method is reported and the followup results showed an excellent neurosurgical outcome. A 16-year-old girl with an aqueduct stenosis was operated on using a free-hand, computer-assisted endoscopic method where a third ventriculostomy was done. This was the first case being carried out in the Hospital Universiti Sains Malaysia. The next two cases were a suprasellar pituitary cyst in an elderly man and a child with an obstructive hydrocephalus who was previously shunted which became infected. Both endoscopic procedures, extirpation of the cyst using a Nd:Yag laser and a third ventriculostomy, respectively, were done under general anaesthesia in the supine position. Follow-up revealed a transient diabetes insipidus in all three cases up to 48 hours after the operation which resolved spontaneously. The fourth case involved an endoscopic removal of retained ventricular catheter after rectal migration of a shunt in an eight-year-old girl with congenital hydrocephalus. The fifth was a free-hand endoscopy with perforation of multiple brain septae in a ten-month-old baby with hydrocephalus secondary to meningitis. The final outcomes for all the cases were favourable hence we conclude that endoscopic neurosurgery is a safe procedure and hope that more neurosurgeons will continue to use this method, especially for the management of intraventricular cyst and hydrocephalus and especially in South East Asia.

Adolescent↗
PubMed1997

Incidence of tumours suitable for radiosurgery in a developing country like Malaysia: retrospective study done before the decision to start a radiosurgery programme.

This is a descriptive epidemiologic study that was done retrospectively for the years 1990-1996. The objective was to determine whether tumours less than 4 cm in diameter are common and thereafter suitable for radiosurgical treatment. The results showed that the incidence of brain tumours less than 4 cm in diameter was 73.3% and about 20% were situated in the eloquent area.

Adolescent↗
PubMed1995

Endoscopic management of craniopharyngiomas: a review of 3 cases.

The authors describe the endoscopic management of cystic craniopharyngiomas in 3 cases. This method has been attempted in cystic craniopharyngiomas using a rigid endoscope. The instrument has been described earlier (7-9). All these operations were done under general anaesthesia. Criteria for endoscopic extirpation and removal included type D, E, F classification according to Yasargil (17). All 3 cases fitted in the F category. There were one female and two male patients. In the female patient an aspiration of cyst contents was performed as a first attempt to relieve her hydrocephalus. Two months later recurrent symptomology necessitated a larger intervention. All cysts were opened using the laser, drained by a Fogarthy balloon-catheter, and the capsule removed by forceps. This technique is safe and provides a reasonable alternative to open microsurgery, radioactive isotope instillation, or radiotherapy. In our series we achieved total removal in one case after the second intervention and partial removal in two cases. There was no mortality directly associated with this procedure and the female patient developed severe electrolyte disturbances after macroscopic total removal. Our results suggest that endoscopic of management of cystic craniopharyngiomas is a safe and effective procedure which could be considered as the initial management for cystic craniopharyngiomas of the intraventricular type.

Adult↗
PubMed1994

Endoscopic diagnosis and treatment of para- and intra-ventricular cystic lesions.

Different cystic lesions can be located in or around the ventricular system, eventually causing hydrocephalus. Twenty-one patients are described where endoscopic intervention, mainly large fenestration towards the ventricular cavity, has been performed. This treatment can sometimes replace open surgery or extracranial shunting. Most rewarding are the arachnoid and ependymal intra- and paraventricular cysts. With careful and adequate endoscopic technique this procedure is safe and much less invasive than other methods described.

Adolescent↗
PubMed1994

A multipurpose cerebral endoscope and reflections on technique and instrumentation in endoscopic neurosurgery.

We discuss our experiences concerning our cerebral endoscope with reflections on various techniques used since 1986. During this time we have had experience with four prototypes. This minimal invasive procedure has been successful to a certain extent both in paediatric and adult patients, stereotactically and by freehand method or both. Further modification for flexibility and manipulation of the optic element is under development.

Adult↗
PubMed1994

A double-blind study of neurotropin in patients with acute ischemic stroke.

Neurotropin was found to reduce brain oedema in an experimental model of brain infarction in the guinea-pig. A randomized double-blind controlled trial with Neurotropin was performed in 220 patients admitted within 24 h after an acute ischemic stroke. 35 of the neurotropin and 41 of the placebo-randomized patients had to be excluded. 10 included patients in the neurotropin and 13 in the placebo-treated group died within the study period of 15 days. A better clinical outcome was observed in the 65 included surviving neurotropin compared with the 56 placebo-treated patients. The size of the infarct and of the oedema zones was significantly more decreased on CT scans from Day 11 compared with Day 3 after stroke in the neurotropin than in the placebo treated group. Neurotropin is helpful in treating brain oedema, related to acute ischemic stroke.

Aged↗
PubMed1993

Diagnostic and therapeutic stereotactic cerebral endoscopy.

Modern neuro-imaging caused a renewed interest in endoscopic techniques. Several indications for stereotactic endoscopy are illustrated. A prototype of a new four channel endoscope is used. Lesions in the posterior part of the third ventricle an even the fourth ventricle are reachable for biopsy. Cystic intra- or paraventricular lesions can be approached stereotactically and treated. Continuous rinsing is mandatory to preserve a clear vision.

Biopsy↗
PubMed1992

Endoscopic treatment of suprasellar arachnoid cysts.

Four cases of large suprasellar arachnoid cysts in children are described. The authors propose a large fenestration into the lateral ventricles and into the basal cisterns as the treatment of choice. A specific multipurpose cerebral endoscope has been designed by the first author. The endoscopic technique with different instruments and with the use of a laser is illustrated. Results and complications are discussed.

Adolescent↗
PubMed1965

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Nursing↗
PubMedDate not supplied

Spontaneous intracerebral hemorrhage in northeast Malaysian patients: a four-year study.

The aim of this study was to compare nonsurgical versus stereotactic aspiration of intracerebral hematomas in relation to clinical aspects, computed tomographic imaging features of the brain, laboratory parameters and specific risk factors that may influence the outcome in southeast Asian Malay patients. Fifty-five of the patients with intracerebral hemorrhage (ICH) underwent stereotactic aspiration and 57 did not. Analysis was done on risk factors, locations and treatments of ICH, and the final outcomes measured by the Glasgow Outcome Scale. A total of 112 patients were evaluated. Mean age was 52 years with ages ranging from 12 to 80 years. Hypertension was seen in 60.7% of patients with ICH. The mortality rate was 25% by 3 months. 58.9% had a poor final outcome, while 41.1% had a good outcome. The selected variables were incorporated into models generated by multiple logistic regression method analysis to define the significant predictors of outcome. Significant predictors of outcome were the Glasgow Coma Scale score on admission, the duration of surgery and the total volume of the hematoma. Significant predictors of mortality were high total white blood cell differential count, low plasma protein, and high plasma lactate dehydrogenase and brain edema. The study suggests that stereotactic aspiration of patients with ICH does not offer any definite advantage over conservative treatment.

Adolescent↗
PubMedDate not supplied

Pseudo-dissection in percutaneous transluminal coronary angioplasty.

Percutaneous transluminal coronary angioplasty (PTCA) is a well-established and effective treatment modality for significant coronary artery disease. Because it enlarges the arterial lumen by plaque disruption, minor wall dissection is not infrequent. Complex dissections are, however, uncommon but may lead to acute vessel closure with its attendant major clinical morbidity and mortality. We describe here a case of pseudo-dissection and its potential for misinterpretation and subsequent inappropriate management.

Aortic Dissection↗