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Biomedical subjects

J A Zitelli

Publications and source records attributed to J A Zitelli.

63 records · Page 4Linked to original sources
PubMed1984

Histologic patterns of congenital nevocytic nevi and implications for treatment.

The therapeutic problems associated with congenital nevocytic nevi (CNN) have lead to a flurry of interest in neonatal dermabrasion. This is based on the theory that nevus cells at birth are superficial and accessible to dermabrasion and that they later migrate into the deeper dermis. We studied twelve patients with CNN, including seven patients less than 3 months of age, with serial biopsies taken over a period of 15 months. In addition, four neonates with giant CNN underwent dermabrasion, and biopsies were obtained pre- and postoperatively. The histologic features of CNN and the implications for treatment are discussed. Our results are inconsistent with the idea of migration of nevus cells into the dermis during infancy. Dermabrasion of giant CNN at an early age may improve the cosmetic appearance; however, it will not remove most nevus cells and is not recommended as an effective treatment for the prevention of melanoma.

Adolescent↗
PubMed1984

Epidermal cell outgrowth from CO2 laser- and scalpel-cut explants: implications for wound healing.

We set out to determine if the slow healing of CO2 laser-incised skin wounds compared with that of scalpel-incised wounds is the result of an inhibitory effect of the CO2 laser energy on the rate of epithelialization. We compared the rate of epidermal outgrowth from laser- and scalpel-cut explants in vitro. The onset of epidermal cell outgrowth (epiboly) from CO2 laser-incised skin was delayed, but there was no difference in the rate of epidermal cell outgrowth. These studies suggest that a delay in onset of epidermal migration, not a decreased rate of epidermal migration, contributes to the slower epithelialization of CO2 laser-incised skin wounds.

Animals↗
PubMed1983

Wound healing by secondary intention. A cosmetic appraisal.

Secondary intention healing is a simple method of wound management that can provide excellent cosmetic results. Wounds located on concave surfaces of the skin heal with a better cosmetic result than those on convex surfaces. The technic of wound care is reviewed and a set of guidelines is presented that helps one to predict the final appearance of healed cutaneous wounds.

Facial Neoplasms↗
PubMed1981

Microscopically controlled surgery in the treatment of carcinoma of the scalp.

Complete microscopic control of the excision of carcinomas of the scalp is of special benefit, because, in this location, there is an unusual tendency for outgrowths to extend for considerable distances beyond the clinically apparent borders of the neoplasms. Microscopic control is achieved through layer-by-layer excision of cancerous tissue and the use of frozen sections for systematic microscopic scanning of the undersurface of each layer. The reliability of this technique is demonstrated by the treatment results obtained in a series of 576 basal cell carcinomas. The cure rate for the 444 patients who were observed for five years or longer was 98.9%. In a series of 131 patients with squamous cell carcinomas, the cure rate for the 83 patients who were observed for five years or more was 98.8%. Conservation of maximal amounts of normal tissue is an added benefit of the microscopic control technique.

Basal Cell Carcinoma↗