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Biomedical subjects

J A Zagzebski

Publications and source records attributed to J A Zagzebski.

At least 19 recordsLinked to original sources
PubMed2007

Normal and shear strain estimation using beam steering on linear-array transducers.

In current ultrasound elastography, only the axial component of the displacement vector is estimated and used to produce strain images. A method was recently proposed by our group to estimate both the axial and lateral components of a displacement vector following a uniaxial compression. Previous work evaluated the technique using both simulations and a mechanically translated phased array transducer. In this paper, we present initial results using beam steering on a linear array transducer attached to a commercial scanner to acquire echo signals for estimating 2-D displacement vectors. Single-inclusion and anthropomorphic breast phantoms with different boundary properties between the inclusion and background material are imaged by acquiring echo data along beam lines ranging from -15 degrees to 15 degrees relative to the compression direction. 1-D cross-correlation is used to calculate "angular displacements" in each acquisition direction, yielding axial and lateral components of the displacement vector. Strain tensor components are estimated from these displacements. Features on shear strain images generated for the inclusion phantom agree with those predicted using FEA analysis. Experimental results demonstrate the utility of this technique on clinical scanners. Shear strain tensors obtained using this method may provide useful information for the differentiation of benign from malignant tumors. For the linear array transducer used in this study, the optimum angular increment is around 3 degrees. However, more work is required for the selection of an appropriate value for the maximum beam angle for optimal performance of this technique.

Humans↗
PubMed2004

Semiautomated thermal lesion segmentation for three-dimensional elastographic imaging.

Several studies have demonstrated that lesion volumes computed from multiple planar slices through the region-of-interest (ROI) are more accurate than volumes estimated assuming simple shapes and incorporating single or orthogonal diameter estimates. However, manual delineation of boundaries on multiple planar 2-D images is tedious and labor-intensive. Automatic extraction of lesion boundaries is, therefore, attractive and imperative to remove subjectivity and reduce assessment time. This paper presents a semiautomated segmentation algorithm for thermal lesions on 3-D elastographic data to obtain both area and volume information. The semiautomated segmentation algorithm is based on thresholding and morphologic opening of both 2-D and 3-D elastographic data. Results obtained on 44 thermal lesions imaged in vitro using elastography were compared to manual delineation of both elastographic and pathology images. Results obtained using semiautomated segmentation demonstrate a close correspondence with manual delineation results. However, area and volume estimates obtained using both manual and semiautomated segmentation of lesions seen on elastograms slightly underestimate areas and volumes measured from pathology.

Algorithms↗
PubMed2004

Estimation of displacement vectors and strain tensors in elastography using angular insonifications.

In current practice, only one out of three components of the tissue displacement vector and one of nine components of the strain tensor are accurately estimated and imaged in ultrasound elastography. Since, only the axial component of both the displacement and strain are imaged, other important elastic parameters, such as shear strains and the Poisson's ratio, also are not imaged. Moreover, reconstruction of the Young's modulus would be significantly improved if all components of the strain tensor were available. In this paper, we describe a new method for estimating all the components of the tissue displacement vector following a quasi-static compression. The method uses displacements estimated from radiofrequency echo-signals along multiple ultrasound beam insonification directions. At each spatial location in the compressed medium, orthogonal tissue displacements in both the axial and lateral direction with respect to the direction of the applied compression are estimated by curve fitting angular displacement vector data calculated for all insonification directions. Following displacement estimation in orthogonal directions, components of the corresponding normal and shear strain tensors are estimated. Simulation and experimental results demonstrate the utility of this technique for the computation of the normal and shear strain tensors.

Algorithms↗
PubMed2004

Temperature dependence of ultrasonic propagation speed and attenuation in excised canine liver tissue measured using transmitted and reflected pulses.

Previous reported data from our laboratory demonstrated the temperature dependence of propagation speed and attenuation of canine tissue in vitro at discrete temperatures ranging from 25 to 95 degrees C. However, concerns were raised regarding heating the same tissue specimen over the entire temperature range, a process that may introduce irreversible and, presumably, cumulative tissue degradation. In this paper propagation speed and attenuation vs temperature are measured using multiple groups of samples, each group heated to a different temperature. Sample thicknesses are measured directly using a technique that uses both transmitted and reflected ultrasound pulses. Results obtained using 3 and 5 MHz center frequencies demonstrate a propagation speed elevation of around 20 m/s in the 22-60 degrees C range, and a decrease of 15 m/s in the 60-90 degrees C range, in agreement with previous results where the same specimens were subjected to the entire temperature range. However, sound speed results reported here are slightly higher than those reported previously, probably due to more accurate measurements of sample thickness in the present experiments. Results also demonstrate that while the propagation speed varies with temperature, it is not a function of tissue coagulation. In contrast, the attenuation coefficient depends on both tissue coagulation effects and temperature elevation.

Animals↗
PubMed2003

Ultrasonic imaging of myocardial strain using cardiac elastography.

Clinical assessment of myocardial ischemia based on visually-assessed wall motion scoring from echocardiography is semiquantitative, operator dependent, and heavily weighted by operator experience and expertise. Cardiac motion estimation methods such as tissue Doppler imaging, used to assess myocardial muscle velocity, provides quantitative parameters such as the strain-rate and strain derived from Doppler velocity. However, tissue Doppler imaging does not differentiate between active contraction and simple rotation or translation of the heart wall, nor does it differentiate tethering (passively following) tissue from active contraction. In this paper, we present a strain imaging modality called cardiac elastography that provides two-dimensional strain information. A method for obtaining and displaying both directional and magnitude cardiac elastograms and displaying strain over the entire cross-section of the heart is described. Elastograms from a patient with coronary artery disease are compared with those from a healthy volunteer. Though observational, the differences suggest that cardiac elastography may be a useful tool for assessment of myocardial function. The method is two-dimensional, real time and avoids the disadvantage of observer-dependent judgment of myocardial contraction and relaxation estimated from conventional echocardiography.

Aged↗
PubMed2002

Ultrasound monitoring of temperature change during radiofrequency ablation: preliminary in-vivo results.

Radiofrequency (RF) ablation is an interstitial focal ablative therapy that can be used in a percutaneous fashion and permits in situ destruction of hepatic tumors. However, local tumor recurrence rates after RF ablative therapy are as high as 34% to 55%, which may be due in part to the inability to monitor accurately temperature profiles in the tissue being ablated, and to visualize the subsequent zone of necrosis (thermal lesion) formed. The goal of the work described in this paper was to investigate methods for the real-time and in vivo monitoring of the spatial distribution of heating and temperature elevation to achieve better control of the degree of tissue damage during RF ablation therapy. Temperature estimates are obtained using a cross-correlation algorithm applied to RF ultrasound (US) echo signal data acquired at discrete intervals during heating. These temperature maps were used to display the initial temperature rise and to continuously update a thermal map of the treated region. Temperature monitoring is currently performed using thermosensors on the prongs (tines) of the RF ablation probe. However, monitoring the spatial distribution of heating is necessary to control the degree of tissue damage produced.

Animals↗
PubMed2002

Elastographic imaging using a handheld compressor.

Elastography is an emerging imaging modality that allows noninvasive imaging of tissue stiffness changes and stiffness values associated with pathology or as a result of therapy. However, many currently-used systems for elastography rely on a fixed geometry transducer and compressor system for imaging. This configuration is disadvantageous for imaging difficult-to-reach regions that are currently accessible with conventional ultrasound. In this paper, we describe a handheld, portable stepper motor controlled system for elastography. This system may reduce motion and jitter errors that are prevalent in completely 'freehand elastography' that employs hand-induced compressions using the transducer. The latter also requires collection of large amounts of data and use of strain estimation algorithms that may not be sensitive to phase changes or use additional preprocessing to minimize decorrelation effects. The stepper motor controlled handheld system provides controlled compressions and synchronized data acquisition. Our technique yields elastograms of a low-contrast phantom that have contrast levels and contrast-to-noise ratios that are comparable to those obtained with a fixed geometry system.

Animals↗
PubMed2002

Temperature dependence of ultrasonic propagation speed and attenuation in canine tissue.

Previously reported data on the temperature dependence of propagation speed in tissues generally span only temperature ranges up to 60 degrees C. However, with the emerging use of thermal ablative therapies, information on variation in this parameter over higher temperature ranges is needed. Measurements of the ultrasonic propagation speed and attenuation in tissue in vitro at discrete temperatures ranging from 25 to 95 degrees C was performed for canine liver, muscle, kidney and prostate using 3 and 5 MHz center frequencies. The objective was to produce information for calibrating temperature-monitoring algorithms during ablative therapy. Resulting curves of the propagation speed vs. temperature for these tissues can be divided into three regions. In the 25-40 degrees C range, the speed of sound increase rapidly with temperature. It increases moderately with temperature in the 40-70 degrees C range, and it then decreases with increasing temperature from 70-95 degrees C. Attenuation coefficient behavior with temperature is different for the various tissues. For liver, the attenuation coefficient is nearly constant with temperature. For kidney, attenuation increases approximately linearly with temperature, while for muscle and prostate tissue, curves of attenuation vs. temperature are flat in the 25-50 degrees C range, slowly rise at medium temperatures (50-70 degrees C), and level off at higher temperatures (70-90 degrees C). Measurements were also conducted on a distilled degassed water sample and the results closely follow values from the literature.

Animals↗
PubMed1999

Nonlinearity parameter for tissue-mimicking materials.

A finite amplitude insert-substitution method has been used to determine the ultrasonic nonlinearity parameter B/A of nine versions of water-based, macroscopically uniform ultrasonically tissue-mimicking (TM) nonfat and fat materials. In this method, the amplitude of the second harmonic following transmission through degassed distilled water with known B/A (B/A = 5.2) and the amplitude of the second harmonic following transmission through the unknown sample are measured. The ratio of these amplitudes allows calculation of the B/A of the sample. Measured B/A values of the nonfat materials range from 5.6 to 6.6. These values compare favorably with published values for nonfat soft tissues. In contrast, the measured B/A values for two tissue-mimicking fat materials are 9.8 and 11.1; these two values represent the low and high end of B/A for most fresh fatty tissues. For comparison, B/A was measured for two commonly available uniform materials, corn oil and ethylene glycol, and the results are in good agreement with published values.

Adipose Tissue↗
PubMed1999

Ultrasound backscatter and attenuation in human liver with diffuse disease.

Ultrasound backscatter and attenuation in the liver were measured in patients with diffuse liver disease and in 35 volunteers who had no history of liver ailments. Measurements were done using radiofrequency (RF) echo signals derived from a clinical scanner; a reference phantom was scanned to account for effects of gain, transmit-receive frequency response and transducer beam patterns on echo data. The mean backscatter coefficient at 3 MHz in livers of 7 patients with fatty infiltration was 6.8 x 10(-3) cm(-1)sr(-1) compared to a mean of 0.5 x 10(-3) cm(-1)sr(-1) in healthy patients. Mean attenuation at 3 MHz was 2.54 dB/cm in fatty livers compared to 1.66 dB/cm in healthy patients. A total of 7 patients with end-stage liver disease (cirrhosis) had attenuation values similar to those in the healthy group, and their mean liver backscatter was somewhat greater than the mean backscatter for healthy livers. Quantitating both backscatter and attenuation should be considered for detecting fatty infiltration; additional processing methods are needed to differentiate cirrhotic changes on the basis of acoustic signals.

Adolescent↗
PubMed1999

Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements.

In a study involving 10 different sites, independent results of measurements of ultrasonic properties on equivalent tissue-mimicking samples are reported and compared. The properties measured were propagation speed, attenuation coefficients, and backscatter coefficients. Reasonably good agreement exists for attenuation coefficients, but less satisfactory results were found for propagation speeds. As anticipated, agreement was not impressive in the case of backscatter coefficients. Results for four sites agreed rather well in both absolute values and frequency dependence, and results from other sites were lower by as much as an order of magnitude. The study is valuable for laboratories doing quantitative studies.

1-Propanol↗
PubMed1999

Definition of the ostium (neck) of an aneurysm revealed by intravascular sonography: an experimental study in canines.

BACKGROUND AND PURPOSE: The major factor influencing the effectiveness of Guglielmi detachable coils (GDCs) in the treatment of saccular aneurysms is the size of the aneurysm's ostium (neck). Current imaging techniques often do not allow accurate assessment of aneurysm neck morphology. The primary purpose of this study was to determine the feasibility of using intravascular sonography to provide this information. METHODS: Lateral and bifurcation aneurysms were created in each of six adult mongrel dogs by using a well-established surgical technique. Aneurysms were evaluated with digital subtraction angiography and intravascular sonography before (n = 12) and after (n = 6) treatment with GDCs. Angiography was performed using standard techniques. Sonography was performed using both a commercially available 2.6F 40-MHz catheter and a preproduction 0.014-inch 40-MHz imaging core wire housed in a Tracker catheter. Angiograms and sonograms were reviewed independently by two observers to assess the clarity and accuracy with which they depicted the size of each aneurysm's ostium. Posttreatment intravascular sonograms were evaluated for the extent to which they depicted the completeness of aneurysm obliteration. Two-dimensional reformatted images were made of the intravascular sonographic pullback sequences. RESULTS: In all instances, intravascular sonography provided clear definition of the aneurysm's neck (ostium) morphology as well as its relationship to the parent artery and adjacent branches, especially when 2D reformatted images were obtained. The position of coils in aneurysms was also clearly defined. CONCLUSION: Intravascular sonography is a novel technique for viewing the ostium (neck) of an aneurysm. It provides information not available with current angiographic methods.

Angiography, Digital Subtraction↗
PubMed1998

Estimating the spatial autocorrelation function for ultrasound scatterers in isotropic media.

The autocorrelation function pertaining to spatial distributions of ultrasonic scatterers in soft tissue is believed to contain useful information related to tissue morphology. A simple processing method applied to radio-frequency echo signals estimates this function for a sample having isotropic scattering conditions. It utilizes backscattered echo signals from the sample and echo signals from a reference object having defined scattering properties. The ratio of the echo signal power spectrum from the sample to the echo signal power spectrum from the reference object is obtained, and corrected for attenuation differences between the two media. This yields a "form factor" for the sample, whose inverse Fourier transform is the autocorrelation function. The method was tested using tissue-mimicking samples for which spatial autocorrelation functions could be modeled from the dimensions of embedded scatterers. The shapes of the measured autocorrelation functions were in reasonable agreement with those estimated, although measured functions overestimated the function at small lag distances. Scatterer diameters estimated from the zeros of the autocorrelation function agreed to within 6% of expected values when the measurement system bandwidth satisfied minimal criteria.

Humans↗
PubMed1997

Ultrasound attenuation and backscatter in the liver during prednisone administration.

Ultrasound attenuation and backscatter changes resulting from glucocorticoid administration were investigated in a dog model. Ten beagle dogs were randomized into two groups: five were given 2 mg/kg/day IM injections of prednisone to induce steroid hepatopathy and five served as controls. Histology showed vacuolization in most hepatocytes of treated animals on the third day of treatment, and larger, midzonally distributed vacuoles from day 7 on. An increase in both ultrasonic attenuation and backscatter was observed in treated dogs during in vivo measurements. Pooled data from the two groups suggest that attenuation elevations precede backscatter changes. Attenuation was significantly higher in the treated animals than in the controls by day 7. Both attenuation and backscatter were significantly higher in livers of treated than untreated dogs when measured by direct application of the transducer on the liver following euthanasia. We conclude that attenuation and backscatter coefficients can detect early changes in the liver associated with steroid hepatopathy. This may be a useful model to investigate detection of diffuse liver disease with ultrasound tissue characterization.

Animals↗
PubMed1997

Phantoms and automated system for testing the resolution of ultrasound scanners.

Tissue-mimicking phantoms and an automated system have been developed for testing the resolution performance of ultrasound scanners by determining detectability of low to higher contrast spherical lesions over the entire depth of field. Axial, lateral and elevational resolutions are accounted for simultaneously and equally. Tissue-mimicking spherical simulated lesions are either 3 or 4 mm in diameter and have one of four different intrinsic material contrasts. For each diameter and contrast, there is a set of 109 lesions in a regular array with coplanar centers extending from 0.5-15.5 cm in depth. With the scan slice superimposed on the spheres, the image is frame-grabbed for automated analysis. A diameter-dependent lesion signal-to-noise ratio is computed for each pixel position in the image, excluding a 5-mm boundary. Two universal thresholds, resulting from maximization of agreement between the automated system and human observers, give rise to a depth range, or "resolution zone", over which detection exists for each type lesion.

Image Enhancement↗
PubMed1997

Attenuation and backscatter estimation using video signal analysis applied to B-mode images.

Most methods for in vivo quantitation of ultrasound attenuation and backscatter are not available clinically because they rely upon acquiring and analyzing radio frequency (rf) echo signals. This paper describes a technique to estimate ultrasound attenuation and backscatter from B-mode image data. The video signal analysis (VSA) technique utilizes images of a reference phantom, taken using the same instrument settings used to record images from the patient or sample, to account for effects of the transducer beam, system gain and signal processing on image data. A 'gray-scale look-up table' is derived to convert image pixel value data within a region of interest to echo signal amplitudes relative to echo signals from the same depth in the reference phantom. These relative echo levels enable estimates of attenuation and backscatter in the region of interest. VSA was used to quantify acoustic properties of test phantoms using 3 different clinical scanners and various transducers. The level of agreement between results obtained with different ultrasound imaging systems was very good. VSA attenuation and backscatter levels also compare favorably with attenuation coefficients and backscatter coefficients obtained using rf analysis.

Humans↗
PubMed1996

Conventional color Doppler velocity sonography versus color Doppler energy sonography for the diagnosis of acute experimental torsion of the spermatic cord.

OBJECTIVE: We compared color Doppler velocity sonography and color Doppler energy sonography for the diagnosis of spermatic cord torsion in a canine model and determined the degree of torsion necessary to acutely halt testicular blood flow. MATERIALS AND METHODS: Spermatic cord torsion was created in five dogs by exposing and rotating the ipsilateral testis 0 degree, 180 degrees, 270 degrees, 360 degrees, 450 degrees, and 540 degrees. Detorsion followed. The testicles were scanned at each torsion stop using both color Doppler velocity sonography and color Doppler energy sonography. Doppler parameters were optimized (by phantom and test scans) and maintained at a tolerable noise level throughout the experiment. Readers who were unaware of the degree of torsion compared flow in the rotated and contralateral control testes. RESULTS: Flow became undetectable by color Doppler velocity sonography and color Doppler energy sonography at 450 degrees in four of five cases and at 540 degrees in one of five cases. We found no significant difference between the velocity and the energy techniques for detecting this absence of flow (p > .05, Wilcoxon test). We found a significant difference in degree of flow for both techniques when comparing controls and all degrees of torsion combined (p < .006, Mann-Whitney test), but significance was achieved at lesser degrees of torsion with the velocity technique than with the energy technique (180 degrees and 360 degrees, respectively, Wilcoxon test). CONCLUSION: Color Doppler energy sonography was not significantly more sensitive than color Doppler velocity sonography for the diagnosis of spermatic cord torsion in this model. Complete occlusion of arterial inflow occurred at 450-540 degrees of torsion.

Animals↗