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Biomedical subjects

J A Witkowski

Publications and source records attributed to J A Witkowski.

At least 127 records · Page 7Linked to original sources
PubMed1978

The prevalence of HLA-B7 in presumed ocular histoplasmosis in patients with peripheral atrophic scars.

Patients identified in the Walkersville, Maryland, epidemiologic study of presumed ocular histoplasmosis as having only peripheral atrophic scars showed no increase in frequency of HLA-B7 over a control population. Because this antigen is increased in patients with a history of active macular or peripapillary lesions, these findings indicate an inherent predisposition in some patients to develop posterior pole lesions after an ocular infection with Histoplasma capsulatum. The precise mechanisms by which the histocompatibility complex participates in the pathogenesis of these lesions is unknown, but our data are compatible with previous suggestions that alterations in the immune response of these individuals are in some way important in the development of disciform scarring in the posterior pole.

Eye Diseases↗
PubMed1978

The prevalence of HLA-B7 in presumed ocular histoplasmosis.

Eighteen patients with the presumed ocular histoplasmosis syndrome were typed for HLA histocompatability antigens and 78% were found to have the B7 antigen. This data implies an underlying immunogenic predisposition to the development of the clinical eye findings and active posterior pole lesions in the presumed ocular histoplasmosis syndrome. It is likely that some feature of the immune system of these patients renders them more susceptible either to the initial infection or to a later activation of posterior pole lesions mediated through immunologic mechanisms.

Eye Diseases↗
PubMed1978

Pulsating fixed drug eruption due to tetracycline.

A 29-year-old woman developed a pulsating, fixed drug eruption following a year's course of both oral and parenteral administration of tetracycline for pharyngitis. Patch testing of tetracycline powder under occlusion at the site confirmed the diagnosis.

Administration, Oral↗
PubMed1977

Nonsuture surgery for basal cell carcinoma: an alternative method.

Eighty-seven basal cell carcinomas were treated by surgical excision. Sites of removal were allowed to heal by secondary intention. Advantages of this method include histologic monitoring of the adequacy of incision, a less formidable surgical procedure, and a cosmetically acceptable scar.

Basal Cell Carcinoma↗
PubMed1977

Crohn's disease--non-caseating granulomas on the legs.

A 27-year-old black man with Crohn's disease and nodules on the legs is described. Such nodules constitute one of three types of cutaneous manifestations which have a histological picture of a non-caseating granuloma. The two other varieties of skin lesions described are: that resulting from a direct spread from the gastrointestinal tract, and that resulting from spread over contiguous skin.

Adult↗
PubMed1976

Growth of human muscle in tissue culture. An improved technique.

A method is described for the culture of normal and diseased human muscle cells. Cell outgrowth was obtained from 63/63 biopsies, and cells differentiated to form myotubes in 57/63 biopsies. The culture technique used readily permitted the growth of both normal and diseased human muscle cells.

Cell Differentiation↗
PubMed1976

A comparison of betamethasone benzoate gel and betamethasone valerate cream.

One hundred and twenty-one patients were treated in a double-blind fashion with .025% betamethasone benzoate gel and 0.1% betamethasone valerate cream. Results were not statistically significant, although 14 of 16 patients with psoriasis showed excellent results with betamethasone benzoate gel, as opposed to six of 14 patients given betamethasone valerate cream.

Betamethasone↗
PubMed1975

Growth of diseased human muscle in combined cultures with normal mouse embryonic spinal cord.

Normal and diseased human muscle cells have been grown in combined cultures with 12-14 day embryonic mouse spinal cord explants. Nerve endings on myotubes were found by light and scanning electron microscopy, and motor end-plates were identified by a histochemical reaction for acetylcholinesterase. Contracting myotubes, never observed in cultures of human muscle alone, were found in a culture from normal muscle. Histochemical studies demonstrated the presence of strongly and weakly reacting myotubes for both ATPase pH 9.4 and NADH-TR, but could not be related to the development of fibre types. No differences in morphology or histochemical reactions were found between normal and diseased muscle cells in these combined cultures.

Acetylcholinesterase↗