Biomedical subjects

J A Wirman

Publications and source records attributed to J A Wirman.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Proliferative myositis in the head and neck.

Benign fibrous lesions in the head and neck include lesions with a wide range of histologic features. Some of these conditions may be mistaken for malignant tumors, leading to unnecessary radical therapy. Proliferative myositis is one such lesion. A 49-year-old man had a one-week history of swelling over the left side of this mandible and upper neck. Most of the mass was removed and the diagnosis of proliferative myositis was confirmed by excisional biopsy. The patient was free of disease one year after surgery.

Diagnosis, Differential↗

PubMedDate not supplied

Benign dermal cylindroma of the external auditory canal: a clinicopathological report.

Considerable confusion exists regarding the nature of benign dermal cylindroma of the external auditory canal. In the past, authors have used the term cylindroma to refer to malignant lesions such as adenoid cystic carcinoma. Benign dermal cylindroma is a specific clinical entity consisting of benign tumors arising from the epidermal appendages; however, whether they are apocrine- or eccrine-derived is not conclusively known. Six per cent are reported to be related to the ear. Histologically they are characterized by cords of basophilic cells, hyaline material, and cystic duct-like structures. Rarely, cases of malignant degeneration are reported. However, for the most part, these lesions are benign and should be treated with complete local excision. Radiotherapy may be useful in treating massive lesions not amenable to surgery.

Adult↗

PubMedDate not supplied

Functional and ultrastructural status of platelets prepared by the Celltrifuge.

Function and morphology of platelets collected by the Celltrifuge were investigated. In vitro platelet tests included aggregation by adenosine diplhosphate, collagen, and epinephrine, ability to support clot retraction, uptake and release of labeles serotonin, and morphology at the ultrastructural level. Each of these tests was also performed on platelets obtained from the same donor before the collection procedure was instituted. Data obtained from pre- and post-Celltrifuge platelet samples were compared and analyzed on individual donor basis as wass as on eight donors as a group. The hemostatic effectiveness of Celltrifuge-collected platelets was evaluated by their ability to raise platelet counts and to shorten the template bleeding time in four thrombocytopenic recipients. Our results indicate that platelets prepared by this continuous flow centrifugation equipment retained their functional and ultrastructural integrity, and significantly raised the platelet counts and shortened the bleeding time of all four patients.

Blood Cell Count↗