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Biomedical subjects

J A Wakefield

Publications and source records attributed to J A Wakefield.

28 records · Page 2Linked to original sources
PubMed1976

Subjective ratings of Cattell's 16 Personality Factors.

The Sixteen Personality Factors Questionnaire (16PF) was administered to 69 subjects. Each subject was asked to rate himself on the 16 personality factors on the 16PF. The 16PF scores and the self-ratings were compared by canonical analysis. Three significant relationships were identified. The relationships primarily involved indices of social interaction from the 16PF and indices of internal traits from the self-ratings.

Journal Article↗
PubMed1976

Differential recovery of intestine, bone marrow, and thymus of rats with solid tumors following 5-fluorouracil administration.

Time relationships for recovery of several host organs from toxic effects of 5-fluorouracil were determined in ACI rats bearing Morris hepatoma 3924A. A single injection of 150 mg/kg body weight 5-fluorouracil (the LD10) resulted in loss of 90% of the tibial bone marrow, 60% of the intestinal mucosa, and 90% of the thymus as measured by total DNA content of the organs. Organ DNA contents following 150 mg/kg of the drug were minimal on day 3 for intestine and on day 5 for marrow and thymus. A return to pretreatment or higher levels of DNA was observed by day 4 for intestine, day 11 for tibial marrow, and day 19 for thymus. Incorporation of 3H-deoxyuridine into host organ DNA after 150 mg/kg 5-fluorouracil was inhibited 36 hrs for intestine, 3 days for thymus, and 5 days for tibial bone marrow. Inhibition of 3H-deoxyuridine incorporation into DNA was similar for 50, 100, and 150 mg/kg doses both in tumor and in host organs, but recovery of 3H-deoxyuridine incorporation and DNA content of host organs began later with the higher doses of 5-fluorouracil. Maximal incorporation of 3H-deoxyuridine into DNA was observed on day 4 for intestine, day 8 for marrow, and day 9 for thymus after treatment with 150 mg/kg 5-fluorouracil. Animal lethality following the second of two 150 mg/kg injections of 5-fluorouracil was related to the extent of recovery of intestinal mucosa and bone marrow at the time of the second injection. Survival decreased to 0% for normal rats when the interval between injections was 3-4 days, improved at 5 days and was 100% when the interval was 10-11 days.

Animals↗
PubMed1975

A common factor in the MMPI scales of married couples.

Using canonical analysis, a common factor in the MMPI scales of husbands and wives was found. The Sc, Pd, and Hs scales for both the husbands and the wives contributed heavily to the relationship. Other scales contributing to the correlation between the personality components of the pairs were F, Hy Pt, and Si for the husbands and Pa for the wives. The results were interpreted as indicating areas of homogeneity and heterogeneity in the personalities of married couples.

Anxiety↗
PubMed1975

An empirical comparison of Maslow's and Murray's needs systems.

The Work Motivation Inventory (WMI), a measure of Maslow's hierarchy of needs, and the Edwards Personal Preference Schedule (EPPS), a measure of Murray's manifest needs, were administered to 372 undergraduates. The two instruments were compared using canonical analysis. The analysis revealed three significant relationships between components of the two instruments. The first relationship supported Maslow's need hierarchy in general and its measurement by the WMI. The second suggested a fluctuating relationship between giving and receiving help and the levels of Maslow's hierarchy. The third relationship suggested that need for Achievement is associated with the intermediate levels of Maslow's hierarchy.

Journal Article↗
PubMedDate not supplied

Sonography of experimental acute renal vein occlusion.

Complete occlusion of the renal vein in five rabbits with the kidney in its normal position was followed by high-resolution ultrasound. Early changes consisted of moderate renal enlargement and a diffuse increase in renal echogenicity with a fine echo pattern. On the average, renal length increased by only 13%. Delayed changes were a gradual reduction in renal echogenicity, falling to below baseline, with blurring of the corticomedullary boundary. Intrarenal hemorrhage alone occurred in only one kidney. Perirenal hematoma were seen in two other cases associated with localized intrarenal hemorrhage adjacent to the point of capsular rupture (overall renal morphology was preserved). The relative subtlety of the changes observed contrasts with previously reported data and is felt to preclude a specific diagnosis.

Animals↗