Biomedical subjects
J A Spittell
Publications and source records attributed to J A Spittell.
Pentoxifylline and vascular disease.
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Evaluation of the patient with intermittent claudication.
The most common cause of intermittent claudication is atherosclerotic occlusive arterial disease. Differentiation of the common musculoskeletal and neurologic conditions that may mimic intermittent claudication is often possible with a careful history, but when insufficient detail is provided or multiple conditions exist, the findings on physical examination and noninvasive studies are useful. While physical examination provides a rough estimate of the degree of ischemia, assessment of functional impairment produced by occlusive arterial disease is best made with noninvasive studies before and after standard exercise. Arteriography is reserved for the patient for whom restoration of pulsatile flow is planned.
The vasospastic disorders.
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Thromboangiitis obliterans--an autoimmune disorder?
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Some uncommon types of occlusive peripheral arterial disease.
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Hypertension and arterial aneurysm.
The rather common coexistence of arterial aneurysm and systemic hypertension may be attributed to their respective frequency as clinical findings. The development of hypertension secondary to renal ischemia that can occur as a complication of certain types of aneurysmal disease is well recognized. Less well appreciated is the evidence to implicate hypertension as a factor in the pathogenesis of arterial aneurysms, perhaps in their progressive enlargement, and even in rupture. Furthermore, after resection of an aneurysm, systemic hypertension adversely influences survival, and it is an important contributing factor in the development of false aneurysms. A relation between hypertension and aortic dissection has received more recognition. Just how systemic hypertension contributes to the occurrence of aortic dissection is not clear, but the effective control of hypertension has the potential for decreasing the incidence of aortic dissection. The curious clinical association of hypertension with the location of the primary tear in the proximal part of the descending aorta (type III or type B) has several plausible explanations.
Occlusive arterial disease in the upper extremities.
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Office and bedside diagnosis of occlusive arterial disease.
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Occlusive peripheral arterial disease. Guidelines for office management.
Occlusive peripheral arterial disease is rather easy to diagnose because of its characteristic symptoms and the ease with which the extremities and their circulation can be examined. Elevation and dependency tests give a rough but reliable estimate of the degree of ischemia, and if more objective data are desired, the systolic blood pressure index can be determined. Management should be individualized according to the degree of disability and ischemia, the expected natural history, and the patient's general health.
Diagnosis and treatment of occlusive peripheral arterial disease.
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Intra-aortic balloon counterpulsation as adjunct to aneurysmectomy in high-risk patients.
Patients with severe coronary artery disease that is not amenable to coronary artery bypass surgery face formidable risks when major aortic surgery becomes necessary. In this report we present such a patient, who successfully underwent abdominal aortic aneurysm resection and graft replacement with the prophylactic use of intra-aortic balloon counterpulsation. The use of intra-aortic balloon counterpulsation at the time of surgery has the potential of improving cardiac function in patients with left ventricular dysfunction and favorably influencing the perioperative and postoperative mortality in these patients. Its use also appears worthy of trial in patients with ruptured abdominal aortic aneurysm and shock, in the hope that it will result in improved survival in these patients.
Recognition and management of chronic atherosclerotic occlusive peripheral arterial disease.
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Perioperative hypertensive crisis and hemorrhagic diathesis: fatal complication of clinically unsuspected pheochromocytoma.
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Clinical aspects of aneurysmal disease.
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Vasospastic disorders: recognition and management.
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Occlusive arterial disease: recognition and management.
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