Biomedical subjects

J A Settle

Publications and source records attributed to J A Settle.

13 recordsLinked to original sources

PubMed1987

A one-year psychological follow-up of the most severely burned victims of the Bradford fire.

The horrific disaster at the Valley Parade Football Stadium, Bradford, on 11 May 1985 left 53 people dead in the fire and many more seriously injured. This detailed study of five of the most seriously injured victims was started 3 weeks after the fire. Patients were interviewed and rating scales (Irritability Depression Anxiety Scale--IDA, Hamilton Depression Rating Scale--HDRS, Spielberger Anxiety Scale--STAI, Beck Depression Inventory--BDI, General Health Questionnaire--GHQ), were completed regularly, until the first anniversary of the disaster. Each victim showed some psychopathology over the study period. Depression and anxiety, the commonest reactions, were most troublesome at times of stress. While it is likely that the disaster itself predisposed the victims to these reactions, the contribution of the stressful events occurring around the time of the disaster cannot be ignored. These findings suggest that IDA, GHQ and STAI function as an effective screening triage for detecting those disaster victims who may need psychological help and support.

Adult↗

PubMed1986

Probable chromosomal mutation to resistance to all aminoglycosides in Staphylococcus aureus selected by the therapeutic use of gentamicin: a preliminary report.

A patient suffering from burns was treated with gentamicin: subsequently, a 'methicillin-resistant' strain of Staphylococcus aureus (B27), was isolated which was highly resistant to this antibiotic and all other aminoglycosides. In all other respects this isolate resembled the gentamicin-sensitive 'methicillin-resistant' S. aureus prevalent on the Yorkshire Regional Burns Unit. Subsequently, fusidic acid treatment was substituted for gentamicin therapy, and a fusidic acid-resistant variant was isolated from the same patient. This article reports a preliminary characterization of these isolates.

Adult↗

PubMed1985

Treatment of burns casualties after fire at Bradford City football ground.

On 11 May 1985 the main stand of Bradford City Football Club caught fire. Within four minutes the stand was alight from end to end. Fifty three people were burnt to death and about 250 injured; 83 required admission to hospital, and 55 of these were treated by primary excision of their burns and skin grafting. In such disasters the help of staff from other hospitals and areas is essential. Patients should be assessed to see whether they have burns that will ultimately be fatal; if they have they should not be sent to regional burns units, where they would take up beds that could be used for patients with treatable burns. All districts should ensure that their plans for accidents in which burns injuries predominate are adequate.

Adult↗

PubMed1985

Infection in burns.

Explore the source record for details and available documents.

Administration, Topical↗

PubMed1983

Urinary protein profiles after burn injury.

A study of the change of urinary protein excretion has been made in 26 patients followed from the time of admission to time of discharge from the Yorkshire Regional Burn Centre (7-200 days). Total protein, IgG and albumin (as indicators of glomerular function) and alpha 1-microglobulin, beta 2-microglobulin, retinol binding protein and N-acetyl-beta-D-glucosaminidase (as indicators of proximal tubular function) as well as the patterns on SDS polyacrylamide gel electrophoresis were examined. Patients were divided into three groups according to their urinary protein profiles. The first group was 3 patients who showed little or no evidence of proteinuria; the second group consisted of 7 patients who showed a mild and transient tubular proteinuria, all of whom recovered normal function within one week. The third group, 16 patients, developed moderate to severe proteinuria usually started as a mixed pattern of glomerular and tubular proteinuria, characterized by the excretion of a high level of total protein. After a few days, this pattern changed to a typical tubular proteinuria and the latter could last for as long as 200 days; in some of these patients a secondary increase of low molecular weight protein excretion occurred either due to a latent renal complication or induced by the administration of aminoglycosides. There is a close correlation between the intensity and patterns of the proteinuria and the severity and clinical progress of the burn.

Acetylglucosaminidase↗

PubMed1981