Biomedical subjects

J A Salva Lacombe

Publications and source records attributed to J A Salva Lacombe.

12 recordsLinked to original sources

PubMed1991

[The effect of duodenal exclusion on the cellular endocrine adaptation of the duodenum after performing an antrectomy. An experimental study in the rat].

We present an experimental study in rats with the aim to value the adaptative variations over the duodenal gastrin and somatostatin cell producing populations after antrectomy and gastrojejunostomy. 30 animals were distributed into two groups of 15 animals each. Group 1 rats underwent antrectomy and gastrojejunostomy, the animals of group 2 were considered as a controls. The results obtained show that after antrectomy and gastrojejunostomy an increase of gastrin producing cells is produced as well as decrease of somatostatin producing cells, both figures are statistically significant, concluding that the duodenum is able to supply the gastric antrum in gastrin production while the duodenal somatostatin cell producing population is negative influenced by the absence of alimentary stimuli and gastric secretions.

Adaptation, Physiological↗

PubMed1991

[Adaptation mechanisms to the short intestine. Influence of the biliopancreatic factor: experimental study].

Massive small bowel resection that results in short bowel syndrome brings about regulatory mechanisms in the remaining intestine aimed at preventing the ensuing malabsorption. The purpose of the present study was to determine the role of pancreatic and biliary secretions in intestinal adaptation after small bowel resection. To do so, both pancreatic and biliary fluids were prevented from reaching the lumen of most of the small bowel. Four groups of animals were prepared: I) control group; II) eighty percent small bowel resection; III) duodenoileal by-pass; and IV) duodenoileal by-pass plus small bowel resection. After a fifteen days recovery period, the following were recorded: animal weight; plasma protein, BUN, cholesterol, glucose, and Ca++; the length and diameter of the jejunum and ileum, the height of the mucosal layer, and microvilli density. Intestinal adaptation was excellent in animals after small bowel resection. All animals in group IV died due to severe malabsorption. Diversion of pancreatic and biliary juice in animals with duodenoileal by-pass did not prevent intestinal adaptation. We conclude that the effect of pancreatic and biliary juice on intestinal adaptation is additive to that of other putative hormonal mechanisms.

Adaptation, Physiological↗

PubMed1990

[Adaptive duodenal endocrine cell changes after antrectomy. Experimental study in the rat].

The known gastric endocrine relationship between "G" cells and "D" cells is altered after the loss of antral "G" cell population after antrectomy, leading to physiologic adaptative changes over the cell population producing gastrin and somatostatin in the duodenum, replacing thus the endocrine function of the resected gastric antrum. In this experimental study, Sprague-Dawley rats have been randomized in two groups, Control and Antrectomy with gastroduodenostomy, maintaining the alimentary stimulation of the duodenum. Endocrine "G" and "D" cell studies have been carried out by immunohistochemical staining with an Avidin-Biotin affinity technique. The statistical method used was the "t" test of Student. The results demonstrated a significant increase of the duodenal "G" cell population without changes of the duodenal "D" cell population after antrectomy and gastroduodenostomy. The endocrine cell ratio "G/D" in the duodenum increases due to the loss of antral gastrin release and the decrease of gastric acid output provoked by antrectomy.

Adaptation, Physiological↗

PubMed1989

[Carcinoid of the bronchi and adenoma of the parathyroid: is it a fortuitous association or a multiple endocrine neoplasm?].

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Adenoma↗

PubMed1989

[Histopathologic changes seen during the reopening of the intestinal lumen after obliteration of the digestive tract with nonabsorbable material. Experimental study in the rat].

The constant pressure exerted by occlusive ligation on the intestinal wall produces ischemia and ulceration of the mucosa, interruption of the muscular layer and transmural inflammatory reaction, which terminates when the ligature is eliminated and the injured tissues are repaired.

Animals↗

PubMed1988