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Biomedical subjects

J A Rush

Publications and source records attributed to J A Rush.

42 records · Page 3Linked to original sources

Biopsy-negative cranial arteritis with complete oculomotor nerve palsy.

Cranial arteritis (CA) presenting as sudden blindness is well documented, and early recognition of this entity in an elderly patient with visual loss or diplopia is of critical importance. This entity presents a difficult diagnostic problem when temporal artery biopsy is negative, as in our case, or when the erythrocyte sedimentation rate is normal. The present report details an unusual patient with "occult temporal arteritis" who sustained abrupt monocular visual loss and subsequent ipsilateral ophthalmoplegia involving all functions of the oculomotor nerve. Despite negative biopsies of each temporal artery, other probable etiologies of the symptom complex were excluded, and the diagnosis of cranial arteritis is warranted. The patient is unique in that the oculomotor palsy is complete and permanent. This report emphasizes cranial arteritis masquerading as an intracranial aneurysm.

Aged↗

Septo-optic dysplasia (de Morsier syndrome).

A 12-year-old girl and a 30-year-old woman had bilateral optic disk hypoplasia and bitemporal hemianopia. By using computed axial tomography on our patients, we demonstrated the absence of the septum pellucidum, which confirmed the diagnosis of septo-optic dysplasia, or the de Morsier syndrome.

Adult↗

Acute macular neuroretinopathy.

A 24-year-old white woman convalescing from a viral upper respiratory infection suddenly developed three positive scotomas around the fixation point in her left eye. The fundus had three corresponding lesions that appeared to be characteristic of acute macular neuroretinopathy. Situated in the fovea, subtle, reddish-brown, wedge- or tear-shaped lesions were best seen with the direct ophthalmoscope using red-free light. Visual acuity was 6/6 (20/20), and peripheral fields were normal. The patient's reproduction of the scotomas on an Amsler grid sheet mirrored the observed ophthalmoscopic findings. Fluorescein angiograms were normal. She had been taking oral contraceptives for many years. Although viral illness and oral contraceptives have been associated with acute macular neuroretinopathy, no etiology was proven, and no treatment is known. The patient remains symptomatic after a six-month follow-up.

Acute Disease↗

Idiopathic optic neuritis of childhood.

I saw two children who had painless unilateral visual loss due to papillitis of unknown cause. Loss of visual acuity was moderate to severe and was accompanied by a central scotoma and color vision impairment. In each case the optic disks were pale and swollen, and retinal exudates formed a partial star figure in the macula. Previous diagnostic considerations in one patient had led to an unnecessary neuroradiologic search for an intracranial lesion. Unilateral neuroretinitis is less common than the bilateral papillitis that usually occurs in children, but should not be mistaken for unilateral papilledema. The visual prognosis for unilateral optic neuritis is excellent; both patients improved to normal or nearly normal visual acuity without treatment, although subtle signs of previous optic neuritis persisted.

Adolescent↗