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Biomedical subjects

J A Porter

Publications and source records attributed to J A Porter.

71 records · Page 4Linked to original sources
PubMed1966

Plasmodium vivax transmitted from man to monkey to man.

Blood forms of human vivax malaria infected splenectomized night monkeys (Aotus trivirgatus). Anopheles albimanus mosquitoes transmitted the in fection from a monkey to two human volunteers; parasites and symptoms ap peared 11 days later. Blood forms of vivax malaria from each of the two humans infected other night monkeys.

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PubMedDate not supplied

Pneumoperitoneum following percutaneous endoscopic gastrostomy. Does the timing of panendoscopy matter?

Percutaneous endoscopic gastrostomy (PEG) has had a significant impact on enteral alimentation in patients unable to maintain adequate oral caloric intake. PEG avoids the morbidity and mortality associated with the traditional feeding gastrostomies placed by celiotomy. Several authors have documented benign, self-limiting pneumoperitoneum following PEG placement. No study has addressed whether the timing of panendoscopy in relation to gastric puncture has an effect on the incidence of post-PEG pneumoperitoneum. The authors prospectively studied 30 patients undergoing PEG. Panendoscopy was either performed before or after gastric puncture, and each patient then had abdominal radiographs to determine the presence of pneumoperitoneum. Four of 16 patients (25%) having panendoscopy prior to gastric puncture had radiographic evidence of pneumoperitoneum compared to three of 14 patients (23%) having panendoscopy following gastric puncture. The authors conclude that the timing of panendoscopy in relation to gastric puncture does not significantly effect the incidence of post-PEG pneumoperitoneum.

Aged↗
PubMedDate not supplied

Hydronephrosis following aorto-femoral bypass grafts.

Hydronephrosis is reported to be an infrequent late complication of aortofemoral bypass operations. To more clearly define the true incidence of the problem, excretory urograms were performed on 53 asymptomatic patients following successful aortic reconstruction. Unilateral hydronephrosis was found in seven of 50 patients (14%) in whom aortofemoral bifurcation grafts were placed. In each instance, the ureteral obstruction occurred at the point where the ureter crossed the graft limb. Dilatation was mild or moderate in all cases, with no significant deterioration of renal function. All seven patients underwent extensive urologic evaluation and have been followed nonoperatively to date. Hydronephrosis produced in a canine aortic-graft model suggests that a dense fibrotic reaction occurs surrounding the prosthesis, and invades the muscular wall of the ureter. Ureteral obstruction after aortofemoral bypass appears to occur more often than previously thought. Routine pre- and post-operative IVP studies are indicated. If renal function remains good, careful follow-up without re-operation seems warranted.

Adult↗
PubMedDate not supplied

Effects of pravastatin on plasma lipid concentrations in poloxamer 407-induced hyperlipidemic rats.

A new animal model of hyperlipidemia is being developed using the nonionic surfactant poloxamer 407 (P-407). We investigated the impact of pravastatin on P-407-induced hyperlipidemia. Twenty rats received P-407 300 mg intraperitoneally to induce hyperlipidemia, and 20 control rats received saline injection. Pravastatin was administered orally to an equal number of rats in both groups using three different regimens. A fourth group did not receive pravastatin. At 24 hours after injection, total cholesterol levels in two of the pravastatin groups were 28% and 34% lower than those in animals that did not receive pravastatin (p < or = 0.01). At 48 hours, triglyceride levels were significantly lower in all pravastatin groups (21-44%) versus animals not receiving pravastatin. Pravastatin diminished the effects of P-407 on lipoproteins. This new animal model may be useful in screening for investigational antihyperlipidemic agents.

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