Biomedical subjects

J A Parks

Publications and source records attributed to J A Parks.

6 recordsLinked to original sources

PubMed1992

Safety profile and efficacy of cefotaxime for the treatment of hospitalized children.

Cefotaxime has been used to treat serious bacterial infections in children since 1982. With the predominant use of cephalosporins in pediatrics, reports of adverse effects of certain compounds have increased. A retrospective review is presented of 2,243 cases of children receiving therapy with cefotaxime in order to evaluate the safety profile and efficacy of cefotaxime in the treatment of serious infections in hospitalized children. Overall, 57 (2.5%) children experienced adverse reactions. These included local reactions in 6 (0.3%), rash in 28 (1.2%), diarrhea in 15 (0.97%), vomiting in 10 (0.7%), abdominal pain in 1 (0.1%), headache in 3 (0.4%), and drug fever in 1 (0.1%). No cases of hemolytic anemia, bleeding, or hyperbilirubinemia were found. Efficacy of treatment for different disease categories ranged from 90.5% to 100%. The percentage of children in any treatment group with a particular laboratory abnormality following initiation of cefotaxime therapy ranged from 0% to 2.6%, and rates of superinfection with bacteria or Candida were 0.4% to 1.7%. Cefotaxime has the distinct advantage of high rates of efficacy and low rates of complications and superinfection among children hospitalized for serious infections.

Adolescent↗

PubMed1985

[(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 4. Substituted 6,7-dichloro-2,3-dihydrobenzofurans derived by ring annelation.

Ring annelation of the [(aminomethyl)aryloxy]acetic acids produced a series of substituted 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acids. Pharmacologic evaluation of these compounds in rats and dogs indicated that several congeners are extremely potent salidiuretics. Clearance and micropuncture experiments in rats for compound 5a confirmed the high-ceiling diuretic profile and demonstrated that 5a has a site of action at the thick ascending limb of Henle's loop.

Acetates↗

PubMed1984

Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity.

A series of substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazoles was prepared and evaluated for their saluretic and uricosuric properties. Pharmacological evaluation of the title compounds was carried out in mice, rats, dogs, and monkeys. The diuretic/saluretic nature of these compounds was observed in all species, whereas the uricosuric activity was best seen in the Cebus monkey. Evaluation of the enantiomers of 8-chloro-3-(o-fluorophenyl)-5,6-dihydrofuro [3,2-f]-1,2-benzisoxazole-6-carboxylic acid (15k) revealed that only the (+) enantiomer (29) displayed diuretic and saluretic activity, whereas both enantiomers possessed uricosuric activity. X-ray analysis showed that the (-) enantiomer (30) possesses the 2R configuration.

Animals↗

PubMed1980

Transducer beam pattern test object.

A new test object has been developed that generates images of transducer beam patterns on B-mode hardcopy. The extent and depth of the transducer focal zone are measured from these images. The predictions made from test object images were verified in the clinical images obtained from two 3.5-MHz focused transducers. Using the test object images, we have found that we can make a more rational selection of transducer for each clinical situation.

Humans↗

PubMed1979

Ultrasonographic demonstration of undescended testes.

Twelve cryptorchid patients had sonographic evaluation of the inguinal region prior to surgical orchiopexy. When the testis was within the inguinal canal, the gonad was localized preoperatively by sonography in eight of nine patients. One patient had an associated inguinal hernia in which loops of bowel concealed the gonad. There were no false positive cases. The authors were not able to show abdominal or pelvic maldescended testes.

Abdomen↗

PubMedDate not supplied

Visualization of B-scan transducer transverse cross-sectional beam patterns.

A technique has been developed to "fool" a B-scanner into imaging the transverse cross-sectional beam pattern of its transducer. This technique can be easily used by clinical personnel to test in-house transducers under their normal conditions of use. The effects of various equipment parameters on the effective beam pattern and the image spatial resolution are demonstrated. It is shown that the technique may be used easily and accurately to measure transducer connector/acoustic axis misalignment.

Equipment Design↗